| Lynx1 Capital Management LP |
| 3.99% | 2.75% | #2 | $2,027.5万 | 153.8万股 | $1,741.4万 | 153.8万股 | 00.00% | 持仓不变 |
| NEA Management Company, LLC |
| 1.08% | 0.84% | #4 | $1,710.6万 | 129.8万股 | $1,469.2万 | 129.8万股 | 00.00% | 持仓不变 |
| Venrock Adviser, LLC |
| 0.4% | 0.43% | #6 | $1,330.5万 | 101.0万股 | $1,142.8万 | 101.0万股 | 00.00% | 持仓不变 |
| Atlas Venture Life Science Advisors, LLC |
| 1.44% | 1.63% | #3 | $1,269.1万 | 96.3万股 | $1,287.3万 | 113.7万股 | -17.4万股-15.32% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #15 | $1,254.5万 | 95.2万股 | $1,177.3万 | 104.0万股 | -8.8万股-8.49% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #58 | $1,077.6万 | 81.8万股 | $520.7万 | 46.0万股 | +35.8万股+77.74% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.42% | 0.41% | #5 | $931.7万 | 70.7万股 | $800.2万 | 70.7万股 | 00.00% | 持仓不变 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.29% | 0.28% | #9 | $869.9万 | 66.0万股 | $747.2万 | 66.0万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | <0.01% | #16 | $713.0万 | 54.1万股 | $258.5万 | 22.8万股 | +31.3万股+136.85% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.33% | 0.36% | #8 | $711.8万 | 54.0万股 | $611.3万 | 54.0万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $599.4万 | 45.5万股 | $352.0万 | 31.1万股 | +14.4万股+46.27% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.03% | 0.04% | #13 | $593.2万 | 45.0万股 | $509.5万 | 45.0万股 | 00.00% | 持仓不变 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.13% | 0.13% | #10 | $548.7万 | 41.6万股 | $471.3万 | 41.6万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 0.09% | 0.11% | #11 | $458.3万 | 34.8万股 | $393.6万 | 34.8万股 | 00.00% | 持仓不变 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $394.0万 | 29.9万股 | $303.1万 | 26.8万股 | +3.1万股+11.66% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #51 | $391.3万 | 29.7万股 | $196.6万 | 17.4万股 | +12.3万股+70.97% | 加仓 |
| 72 Investment Holdings, LLC |
| 7.3% | 6.32% | #1 | $364.9万 | 27.7万股 | $313.4万 | 27.7万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #68 | $306.5万 | 23.3万股 | $158.9万 | 14.0万股 | +9.2万股+65.73% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $294.6万 | 22.4万股 | $168.2万 | 14.9万股 | +7.5万股+50.48% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #25 | $234.7万 | 17.8万股 | $187.3万 | 16.5万股 | +1.3万股+7.61% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #69 | $164.6万 | 12.5万股 | $70.4万 | 6.9万股 | +5.6万股+82.08% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $163.2万 | 12.4万股 | $304.6万 | 26.9万股 | -14.5万股-54.00% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #38 | $156.1万 | 11.8万股 | $72.0万 | 6.4万股 | +5.5万股+86.20% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #60 | $154.2万 | 11.7万股 | $57.2万 | 5.1万股 | +6.6万股+131.46% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #23 | $145.7万 | 11.1万股 | $154.2万 | 13.6万股 | -2.6万股-18.87% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #54 | $139.0万 | 10.5万股 | $24.5万 | 2.2万股 | +8.4万股+386.50% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $116.1万 | 8.8万股 | $65.3万 | 5.8万股 | +3.0万股+52.66% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #47 | $98.7万 | 7.5万股 | $47.0万 | 4.2万股 | +3.3万股+80.31% | 加仓 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.03% | 0.03% | #14 | $83.8万 | 6.4万股 | $71.2万 | 6.3万股 | +707股+1.12% | 加仓 |
| F/m Investments LLC |
| 0.04% | 0.05% | #12 | $83.8万 | 6.4万股 | $71.2万 | 6.3万股 | +707股+1.12% | 加仓 |
| Walleye资本Walleye Capital LLC |
| <0.01% | — | #21 | $71.6万 | 5.4万股 | $0 | 0股 | +5.4万股 | 新买入 |
| Quantinno资本管理Quantinno Capital Management LP |
| <0.01% | <0.01% | #34 | $69.5万 | 5.3万股 | $40.7万 | 3.6万股 | +1.7万股+46.53% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #80 | $68.1万 | 5.2万股 | $0 | 0股 | +5.2万股 | 新买入 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #55 | $64.5万 | 4.9万股 | $48.5万 | 4.3万股 | +6,082股+14.20% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #17 | $63.0万 | 4.8万股 | $68.5万 | 6.0万股 | -1.3万股-20.92% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #78 | $62.3万 | 4.7万股 | $231.0万 | 20.4万股 | -15.7万股-76.83% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #89 | $51.4万 | 3.9万股 | $44.0万 | 3.9万股 | +75股+0.19% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #18 | $47.3万 | 3.6万股 | $47.5万 | 4.2万股 | -6,147股-14.64% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #48 | $45.1万 | 3.4万股 | $0 | 0股 | +3.4万股 | 新买入 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | — | #19 | $44.7万 | 3.4万股 | $0 | 0股 | +3.4万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #71 | $41.8万 | 3.2万股 | $24.6万 | 2.2万股 | +1.0万股+46.02% | 加仓 |
| AIHC Capital Management Ltd |
| 0.38% | 0.29% | #7 | $39.9万 | 3.0万股 | $34.3万 | 3.0万股 | 00.00% | 持仓不变 |
| MarinerMariner, LLC |
| <0.01% | <0.01% | #43 | $36.8万 | 2.8万股 | $29.2万 | 2.6万股 | +2,089股+8.09% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #57 | $34.6万 | 2.6万股 | $2.7万 | 2,354股 | +2.4万股+1,015.29% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| <0.01% | — | #31 | $33.7万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $31.8万 | 2.4万股 | $15.2万 | 1.3万股 | +1.1万股+80.01% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #92 | $29.7万 | 2.3万股 | $802.1万 | 16.7万股 | -14.5万股-86.57% | 减仓 |
| IEQ资本IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #28 | $28.0万 | 2.1万股 | $14.5万 | 1.3万股 | +8,469股+66.28% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #52 | $25.1万 | 1.9万股 | $38.9万 | 3.4万股 | -1.5万股-44.50% | 减仓 |
| 古根海姆资本GUGGENHEIM CAPITAL LLC |
| <0.01% | <0.01% | #26 | $24.3万 | 1.8万股 | $16.0万 | 1.4万股 | +4,303股+30.52% | 加仓 |
