| Federated HermesFEDERATED HERMES, INC. |
| 0.04% | 0.05% | #11 | $2,592.1万 | 467.0万股 | $3,080.7万 | 511.3万股 | -44.3万股-8.66% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #14 | $2,432.1万 | 438.6万股 | $0 | 0股 | +438.6万股 | 新买入 |
| Vivo Capital, LLC |
| 2.19% | 2.17% | #3 | $2,399.1万 | 432.3万股 | $2,604.5万 | 432.3万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.03% | #12 | $2,362.6万 | 425.7万股 | $2,565.8万 | 425.9万股 | -1,600股-0.04% | 减仓 |
| Logos Global Management LP |
| 0.79% | 0.97% | #8 | $1,825.3万 | 328.9万股 | $1,937.0万 | 321.5万股 | +7.4万股+2.29% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.06% | 0.08% | #10 | $1,312.6万 | 236.5万股 | $1,424.9万 | 236.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #28 | $1,243.5万 | 224.1万股 | $376.5万 | 62.5万股 | +161.6万股+258.57% | 加仓 |
| Ally Bridge Group (NY) LLC |
| 10.68% | 8.06% | #1 | $1,207.6万 | 217.6万股 | $997.4万 | 165.6万股 | +52.0万股+31.43% | 加仓 |
| Foresite Capital Management VI LLC |
| 1.71% | 2.6% | #5 | $1,102.0万 | 198.6万股 | $1,196.9万 | 198.7万股 | -1,016股-0.05% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $1,050.5万 | 189.3万股 | $1,112.1万 | 184.6万股 | +4.7万股+2.54% | 加仓 |
| Spruce Street Capital LP |
| 1.8% | 2.4% | #4 | $918.8万 | 165.6万股 | $997.4万 | 165.6万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #13 | $787.5万 | 141.9万股 | $854.9万 | 141.9万股 | 00.00% | 持仓不变 |
| Trails Edge Capital Partners, LP |
| 1.25% | 1.96% | #6 | $787.5万 | 141.9万股 | $854.9万 | 141.9万股 | 00.00% | 持仓不变 |
| Seven Fleet Capital Management LP |
| 0.92% | 0.48% | #7 | $555.8万 | 100.1万股 | $149.7万 | 24.8万股 | +75.3万股+303.01% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #25 | $540.9万 | 97.4万股 | $204.3万 | 33.9万股 | +63.6万股+187.61% | 加仓 |
| DV EQUITIES, LLC |
| 0.6% | — | #9 | $418.7万 | 75.4万股 | $0 | 0股 | +75.4万股 | 新买入 |
| ACUTA CAPITAL PARTNERS, LLC |
| 2.74% | 3.02% | #2 | $393.8万 | 71.0万股 | $427.5万 | 71.0万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $296.1万 | 53.4万股 | $426.7万 | 70.8万股 | -17.5万股-24.66% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #34 | $235.8万 | 42.5万股 | $34.0万 | 5.6万股 | +36.9万股+654.08% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #23 | $167.9万 | 30.3万股 | $159.1万 | 26.4万股 | +3.9万股+14.60% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #27 | $162.1万 | 29.2万股 | $56.2万 | 9.3万股 | +19.9万股+213.07% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #38 | $130.3万 | 23.5万股 | $0 | 0股 | +23.5万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #35 | $79.9万 | 14.4万股 | $19.3万 | 3.2万股 | +11.2万股+349.69% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #33 | $63.1万 | 11.4万股 | $18.7万 | 3.1万股 | +8.3万股+266.53% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #36 | $41.9万 | 7.6万股 | $0 | 0股 | +7.6万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #19 | $40.7万 | 7.3万股 | $54.0万 | 9.0万股 | -1.6万股-18.28% | 减仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.01% | — | #15 | $35.9万 | 6.5万股 | $0 | 0股 | +6.5万股 | 新买入 |
| Walleye资本Walleye Capital LLC |
| <0.01% | — | #17 | $29.9万 | 5.4万股 | $0 | 0股 | +5.4万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #37 | $25.2万 | 4.5万股 | $0 | 0股 | +4.5万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #43 | $23.4万 | 4.2万股 | $40.7万 | 6.8万股 | -2.5万股-37.53% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | — | #48 | $22.0万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #50 | $20.9万 | 3.8万股 | $24.1万 | 4.0万股 | -2,238股-5.60% | 减仓 |
| Apella资本Apella Capital, LLC |
| <0.01% | <0.01% | #16 | $20.2万 | 4.2万股 | $28.4万 | 4.2万股 | 00.00% | 持仓不变 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #40 | $18.5万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #46 | $16.8万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #30 | $16.6万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #49 | $15.5万 | 2.8万股 | $0 | 0股 | +2.8万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #32 | $14.2万 | 2.6万股 | $12.9万 | 2.1万股 | +4,281股+20.01% | 加仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #29 | $11.0万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | — | #44 | $8.9万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| 未来资产环球ETFMIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #31 | $8.7万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #41 | $8.5万 | 1.5万股 | $14.4万 | 2.4万股 | -8,518股-35.71% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #55 | $7.7万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #57 | $6.9万 | 1.2万股 | $2.3万 | 1.1万股 | +1,435股+13.04% | 加仓 |
| 新泽西州警察消防退休系统Police & Firemen's Retirement System of New Jersey |
| <0.01% | — | #22 | $5.7万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #47 | $4.4万 | 7,893股 | $374 | 62股 | +7,831股+12,630.65% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #52 | $3.8万 | 6,826股 | $880 | 146股 | +6,680股+4,575.34% | 加仓 |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #20 | $2.0万 | 3,677股 | $0 | 0股 | +3,677股 | 新买入 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | — | #56 | $1.8万 | 3,320股 | $0 | 0股 | +3,320股 | 新买入 |
| Ameritas Investment Partners, Inc. |
| <0.01% | — | #21 | $1.7万 | 3,090股 | $0 | 0股 | +3,090股 | 新买入 |
