| BVF INC/IL |
| 0.63% | 0.62% | #5 | $2,479.6万 | 629.3万股 | $1,938.3万 | 629.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $2,018.8万 | 512.4万股 | $1,349.7万 | 438.2万股 | +74.2万股+16.92% | 加仓 |
| Defilade Capital Management, L.P. |
| 1.86% | 1.54% | #2 | $1,389.0万 | 352.5万股 | $1,097.8万 | 356.4万股 | -3.9万股-1.09% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #79 | $1,346.4万 | 341.7万股 | $1,014.3万 | 329.3万股 | +12.4万股+3.77% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #54 | $989.1万 | 251.0万股 | $114.0万 | 37.0万股 | +214.0万股+578.30% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #22 | $827.9万 | 210.1万股 | $759.2万 | 246.5万股 | -36.4万股-14.75% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #74 | $771.1万 | 195.7万股 | $552.0万 | 179.2万股 | +16.5万股+9.20% | 加仓 |
| Catalio Capital Management, LP |
| 1.26% | 1.06% | #4 | $667.9万 | 169.5万股 | $505.1万 | 164.0万股 | +5.5万股+3.37% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #91 | $639.1万 | 162.2万股 | $355.6万 | 115.5万股 | +46.7万股+40.47% | 加仓 |
| Zimmer 合伙人Zimmer Partners, LP |
| 0.14% | 0.14% | #12 | $629.1万 | 159.7万股 | $577.5万 | 187.5万股 | -27.8万股-14.85% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.61% | 0.87% | #6 | $469.3万 | 119.1万股 | $545.8万 | 177.2万股 | -58.1万股-32.78% | 减仓 |
| AWM Investment Company, Inc. |
| 0.38% | 0.38% | #8 | $433.4万 | 110.0万股 | $338.8万 | 110.0万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #67 | $413.0万 | 104.8万股 | $168.6万 | 54.7万股 | +50.1万股+91.48% | 加仓 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 0.42% | 0.35% | #7 | $409.5万 | 103.9万股 | $320.1万 | 103.9万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #49 | $386.0万 | 98.0万股 | $0 | 0股 | +98.0万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #84 | $347.9万 | 88.3万股 | $267.8万 | 87.0万股 | +1.4万股+1.56% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.12% | 0.18% | #13 | $255.2万 | 64.8万股 | $300.1万 | 97.4万股 | -32.7万股-33.52% | 减仓 |
| 22NW, LP |
| 2.4% | 1.54% | #1 | $250.7万 | 63.6万股 | $196.0万 | 63.6万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $242.9万 | 61.6万股 | $167.5万 | 54.4万股 | +7.3万股+13.34% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $228.9万 | 58.1万股 | $53.1万 | 17.2万股 | +40.9万股+236.99% | 加仓 |
| CM Management, LLC |
| 1.44% | 1.67% | #3 | $226.6万 | 57.5万股 | $200.2万 | 65.0万股 | -7.5万股-11.54% | 减仓 |
| Blue Owl Capital Holdings LP |
| 0.32% | 1.18% | #9 | $223.2万 | 56.7万股 | $437.3万 | 142.0万股 | -85.3万股-60.10% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #93 | $220.8万 | 56.0万股 | $33.9万 | 11.0万股 | +45.0万股+409.72% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #76 | $212.2万 | 53.9万股 | $20.4万 | 6.7万股 | +47.2万股+703.12% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #109 | $210.1万 | 53.3万股 | $132.4万 | 43.0万股 | +10.3万股+24.07% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #71 | $208.4万 | 52.9万股 | $155.2万 | 50.4万股 | +2.5万股+5.00% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #83 | $201.2万 | 51.1万股 | $13.9万 | 4.5万股 | +46.6万股+1,034.83% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #107 | $191.1万 | 48.5万股 | $61.9万 | 23.9万股 | +24.6万股+102.83% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #106 | $124.1万 | 31.5万股 | $15.1万 | 4.9万股 | +26.6万股+544.13% | 加仓 |
| Triumph Capital Management |
| 0.22% | — | #11 | $119.6万 | 30.3万股 | $0 | 0股 | +30.3万股 | 新买入 |
| Brevan Howard资本管理Brevan Howard Capital Management LP |
| 0.01% | 0.01% | #28 | $117.5万 | 30.5万股 | $68.0万 | 22.9万股 | +7.6万股+33.32% | 加仓 |
| BIT Capital GmbH |
| 0.03% | 0.02% | #17 | $104.8万 | 26.6万股 | $41.3万 | 13.4万股 | +13.2万股+98.51% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #101 | $97.5万 | 24.7万股 | $59.8万 | 19.4万股 | +5.3万股+27.51% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #89 | $82.4万 | 20.9万股 | $23.5万 | 7.6万股 | +13.3万股+174.07% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #52 | $79.2万 | 20.1万股 | $7.6万 | 2.5万股 | +17.6万股+716.67% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #104 | $65.8万 | 16.7万股 | $44.4万 | 14.4万股 | +2.3万股+15.80% | 加仓 |
| LPL金融LPL Financial LLC |
| <0.01% | <0.01% | #108 | $44.0万 | 11.2万股 | $23.1万 | 7.5万股 | +3.7万股+49.01% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | — | #46 | $43.3万 | 11.0万股 | $0 | 0股 | +11.0万股 | 新买入 |
| 梅文证券Maven Securities LTD |
| 0.01% | — | #27 | $39.4万 | 10.0万股 | $0 | 0股 | +10.0万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #82 | $34.9万 | 8.9万股 | $14.7万 | 4.8万股 | +4.1万股+86.05% | 加仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #87 | $34.9万 | 8.9万股 | $2.7万 | 8,800股 | +8.0万股+906.78% | 加仓 |
| Prodigy Asset Management LLC |
| 0.1% | — | #14 | $34.2万 | 8.7万股 | $0 | 0股 | +8.7万股 | 新买入 |
| Daytona Street Capital LLC |
| 0.23% | 0.2% | #10 | $31.3万 | 8.1万股 | $25.4万 | 8.1万股 | 00.00% | 持仓不变 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #112 | $30.2万 | 7.7万股 | $27.5万 | 8.9万股 | -1.3万股-14.22% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #125 | $29.5万 | 7.5万股 | $11.3万 | 3.7万股 | +3.8万股+104.94% | 加仓 |
| 洛克菲勒资本管理Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #73 | $28.6万 | 7.3万股 | $22.1万 | 7.2万股 | +1,000股+1.40% | 加仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| <0.01% | <0.01% | #35 | $28.3万 | 7.2万股 | $3.1万 | 1.0万股 | +6.2万股+609.82% | 加仓 |
| Shay Capital LLC |
| 0.02% | — | #20 | $25.2万 | 6.4万股 | $0 | 0股 | +6.4万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #139 | $25.2万 | 6.4万股 | $15.5万 | 5.0万股 | +1.4万股+27.55% | 加仓 |
| Cambridge Investment Research Advisors, Inc. |
| <0.01% | <0.01% | #66 | $23.6万 | 6.0万股 | $14.8万 | 4.8万股 | +1.2万股+24.36% | 加仓 |
