| Lynx1 Capital Management LP |
| 1.55% | 1.28% | #2 | $786.0万 | 801.9万股 | $809.9万 | 801.9万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 0.14% | 0.18% | #5 | $545.4万 | 556.4万股 | $562.0万 | 556.4万股 | 00.00% | 持仓不变 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.01% | 0.02% | #8 | $272.9万 | 278.5万股 | $281.3万 | 278.5万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $211.6万 | 215.9万股 | $217.6万 | 215.4万股 | +4,575股+0.21% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #19 | $191.1万 | 195.0万股 | $122.1万 | 120.9万股 | +74.1万股+61.26% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #15 | $130.0万 | 132.7万股 | $137.8万 | 136.5万股 | -3.8万股-2.78% | 减仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #17 | $128.0万 | 130.6万股 | $20.1万 | 20.2万股 | +110.4万股+546.50% | 加仓 |
| Deer Management Co. LLC |
| 0.11% | 0.2% | #6 | $122.1万 | 124.6万股 | $125.8万 | 124.6万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #24 | $114.0万 | 116.4万股 | $147.5万 | 146.0万股 | -29.7万股-20.32% | 减仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #12 | $102.9万 | 105.0万股 | $81.6万 | 80.8万股 | +24.1万股+29.87% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #30 | $98.9万 | 100.9万股 | $32.2万 | 31.8万股 | +69.1万股+216.92% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #40 | $97.5万 | 99.5万股 | $185.9万 | 184.1万股 | -84.6万股-45.97% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | — | #10 | $75.7万 | 77.2万股 | $0 | 0股 | +77.2万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #23 | $67.4万 | 68.7万股 | $24.0万 | 23.7万股 | +45.0万股+189.60% | 加仓 |
| DC Funds, LP |
| 49.27% | 42.4% | #1 | $61.7万 | 63.0万股 | $63.0万 | 63.0万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #36 | $57.3万 | 58.5万股 | $62.3万 | 61.7万股 | -3.2万股-5.21% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #26 | $53.7万 | 54.8万股 | $32.3万 | 32.0万股 | +22.9万股+71.60% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.03% | 0.02% | #7 | $53.7万 | 54.8万股 | $38.3万 | 37.9万股 | +16.9万股+44.63% | 加仓 |
| Kalehua Capital Management LLC |
| 0.32% | — | #3 | $44.6万 | 45.5万股 | $0 | 0股 | +45.5万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #32 | $35.7万 | 36.4万股 | $30.9万 | 30.6万股 | +5.8万股+19.03% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #37 | $23.7万 | 24.1万股 | $14.6万 | 14.4万股 | +9.7万股+67.21% | 加仓 |
| Verdad Advisers, LP |
| 0.22% | 0.15% | #4 | $22.8万 | 23.3万股 | $13.5万 | 13.4万股 | +9.9万股+73.70% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #49 | $20.3万 | 20.7万股 | $20.9万 | 20.7万股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #44 | $19.4万 | 19.8万股 | $154.3万 | 84.8万股 | -65.0万股-76.65% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #25 | $16.1万 | 16.5万股 | $0 | 0股 | +16.5万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #14 | $14.6万 | 14.9万股 | $6.1万 | 6.1万股 | +8.9万股+146.16% | 加仓 |
| 布朗兄弟哈里曼BROWN BROTHERS HARRIMAN & CO |
| <0.01% | <0.01% | #22 | $14.0万 | 14.3万股 | $14.4万 | 14.3万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #39 | $13.6万 | 13.9万股 | $9.8万 | 9.7万股 | +4.1万股+42.41% | 加仓 |
| 莱特科·布罗索联合LETKO, BROSSEAU & ASSOCIATES INC |
| <0.01% | <0.01% | #18 | $9.4万 | 9.6万股 | $9.7万 | 9.6万股 | 00.00% | 持仓不变 |
| NewEdge财富NewEdge Wealth, LLC |
| <0.01% | <0.01% | #21 | $9.0万 | 9.1万股 | $9.2万 | 9.1万股 | 00.00% | 持仓不变 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #20 | $7.5万 | 7.7万股 | $11.3万 | 11.2万股 | -3.5万股-31.28% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $6.9万 | 7.1万股 | $3.8万 | 3.7万股 | +3.3万股+89.21% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #42 | $6.8万 | 6.9万股 | $5.3万 | 5.3万股 | +1.7万股+32.02% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #47 | $6.7万 | 6.9万股 | $3.3万 | 3.2万股 | +3.6万股+112.02% | 加仓 |
| Stifel金融STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #34 | $6.7万 | 6.8万股 | $7.0万 | 6.9万股 | -1,200股-1.73% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #43 | $6.4万 | 6.5万股 | $6.6万 | 6.5万股 | 00.00% | 持仓不变 |
| Kestra顾问服务Kestra Advisory Services, LLC |
| <0.01% | <0.01% | #27 | $6.1万 | 6.3万股 | $6.3万 | 6.3万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #53 | $4.8万 | 4.9万股 | $5.8万 | 5.8万股 | -8,429股-14.65% | 减仓 |
| 俄亥俄州公务员退休系统PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
| <0.01% | <0.01% | #31 | $3.6万 | 3.7万股 | $2.8万 | 2.8万股 | +8,900股+32.13% | 加仓 |
| DC Investments Management, LLC |
| 0.01% | 0.01% | #9 | $3.5万 | 3.6万股 | $3.6万 | 3.6万股 | 00.00% | 持仓不变 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| <0.01% | — | #16 | $2.5万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #45 | $2.4万 | 2.5万股 | $2.4万 | 2.5万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #54 | $2.3万 | 2.4万股 | $15.9万 | 15.7万股 | -13.4万股-84.98% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #52 | $1.9万 | 1.9万股 | $1.7万 | 1.7万股 | +2,090股+12.24% | 加仓 |
| R Squared Ltd |
| 0.01% | — | #11 | $1.8万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| 先锋领航个性化指数管理Vanguard Personalized Indexing Management, LLC |
| <0.01% | <0.01% | #29 | $1.8万 | 1.8万股 | $2.2万 | 2.1万股 | -3,400股-15.92% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #55 | $1.6万 | 1.6万股 | $1.5万 | 1.6万股 | +22股+0.13% | 加仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #48 | $1.5万 | 1.6万股 | $1.6万 | 1.6万股 | 00.00% | 持仓不变 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #41 | $1.2万 | 1.2万股 | $9,853 | 9,756股 | +2,489股+25.51% | 加仓 |
| Aries Wealth Management |
| <0.01% | <0.01% | #13 | $9,801 | 1.0万股 | $1.0万 | 1.0万股 | 00.00% | 持仓不变 |
