| EQT Fund Management S.a r.l. |
| 7.74% | 5.28% | #2 | $6,674.3万 | 514.2万股 | $5,393.9万 | 514.2万股 | 00.00% | 持仓不变 |
| Sanofi |
| 6.76% | 8.69% | #3 | $3,612.5万 | 278.3万股 | $2,919.5万 | 278.3万股 | 00.00% | 持仓不变 |
| Redmile Group, LLC |
| 2.38% | 0.11% | #4 | $3,548.6万 | 273.4万股 | $163.9万 | 15.6万股 | +257.8万股+1,649.71% | 加仓 |
| Cormorant Asset Management, LP |
| 1.62% | 1.3% | #5 | $3,200.0万 | 246.5万股 | $2,586.2万 | 246.5万股 | 00.00% | 持仓不变 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.64% | 0.62% | #8 | $2,665.1万 | 205.3万股 | $2,153.8万 | 205.3万股 | 00.00% | 持仓不变 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.03% | 0.03% | #15 | $2,100.2万 | 161.8万股 | $1,697.3万 | 161.8万股 | 00.00% | 持仓不变 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.68% | 0.47% | #7 | $2,035.5万 | 156.8万股 | $1,285.2万 | 120.0万股 | +36.8万股+30.68% | 加仓 |
| Casdin Capital, LLC |
| 1.01% | 1.23% | #6 | $2,011.9万 | 155.0万股 | $1,626.0万 | 155.0万股 | 00.00% | 持仓不变 |
| Andera Partners |
| 9.67% | 9.12% | #1 | $1,997.2万 | 153.9万股 | $1,614.1万 | 153.9万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #23 | $1,893.4万 | 145.9万股 | $1,530.2万 | 145.9万股 | 00.00% | 持仓不变 |
| 安本标准投资Aberdeen Group plc |
| 0.02% | 0.01% | #18 | $1,099.0万 | 84.7万股 | $742.3万 | 70.8万股 | +13.9万股+19.65% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.12% | 0.12% | #12 | $778.8万 | 60.0万股 | $629.4万 | 60.0万股 | 00.00% | 持仓不变 |
| Samsara BioCapital, LLC |
| 0.64% | 0.61% | #9 | $778.8万 | 60.0万股 | $629.4万 | 60.0万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 0.11% | 0.12% | #13 | $533.8万 | 41.1万股 | $431.4万 | 41.1万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.05% | — | #14 | $250.2万 | 19.3万股 | $0 | 0股 | +19.3万股 | 新买入 |
| PFIZER INC |
| 0.61% | 0.34% | #10 | $103.6万 | 7.5万股 | $81.4万 | 7.5万股 | 00.00% | 持仓不变 |
| ALPS顾问ALPS ADVISORS INC |
| <0.01% | — | #20 | $64.9万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
| Bellevue 集团Bellevue Group AG |
| 0.01% | 0.01% | #19 | $63.9万 | 4.9万股 | $52.5万 | 5.0万股 | -752股-1.50% | 减仓 |
| SEVEN GRAND MANAGERS, LLC |
| 0.02% | 0.14% | #16 | $61.8万 | 4.8万股 | $209.8万 | 20.0万股 | -15.2万股-76.20% | 减仓 |
| SECTORAL ASSET MANAGEMENT INC |
| 0.39% | 0.4% | #11 | $56.5万 | 4.4万股 | $47.7万 | 4.4万股 | 00.00% | 持仓不变 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.02% | 0.02% | #17 | $45.4万 | 3.5万股 | $36.7万 | 3.5万股 | 00.00% | 持仓不变 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #21 | $26.6万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $23.5万 | 1.8万股 | $14.9万 | 1.4万股 | +3,831股+26.90% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | <0.01% | #25 | $22.2万 | 1.7万股 | $24.8万 | 2.4万股 | -6,651股-28.03% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #29 | $15.3万 | 1.2万股 | $37.5万 | 3.6万股 | -2.4万股-66.98% | 减仓 |
| XTX资本XTX Topco Ltd |
| <0.01% | — | #22 | $13.3万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | — | #28 | $12.3万 | 9,496股 | $0 | 0股 | +9,496股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #32 | $2.8万 | 2,128股 | $6.8万 | 6,437股 | -4,309股-66.94% | 减仓 |
| GAMMA Investing LLC |
| <0.01% | — | #24 | $1.7万 | 1,344股 | $0 | 0股 | +1,344股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #33 | $1.6万 | 1,200股 | $0 | 0股 | +1,200股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #30 | $9,787 | 754股 | $0 | 0股 | +754股 | 新买入 |
| Larson Financial 集团Larson Financial Group LLC |
| <0.01% | — | #26 | $9,060 | 698股 | $0 | 0股 | +698股 | 新买入 |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #34 | $26 | 2股 | $21 | 2股 | 00.00% | 持仓不变 |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #31 | $26 | 2股 | $0 | 0股 | +2股 | 新买入 |
