| EQT Fund Management S.a r.l. |
| 11.18% | 15.37% | #1 | $9,640.1万 | 695.0万股 | $1.57亿 | 590.0万股 | +105.0万股+17.80% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.04% | 0.07% | #15 | $2,995.7万 | 216.0万股 | $4,645.1万 | 174.7万股 | +41.3万股+23.63% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #21 | $2,832.9万 | 204.2万股 | $2,427.8万 | 91.3万股 | +112.9万股+123.70% | 加仓 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 6.79% | 15.97% | #2 | $2,089.2万 | 150.6万股 | $4,467.9万 | 168.0万股 | -17.4万股-10.36% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #33 | $1,430.8万 | 103.2万股 | $428.9万 | 16.1万股 | +87.0万股+539.62% | 加仓 |
| BRAIDWELL LP |
| 0.43% | — | #8 | $1,157.0万 | 83.4万股 | $0 | 0股 | +83.4万股 | 新买入 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.17% | 0.26% | #10 | $1,121.8万 | 80.9万股 | $1,313.1万 | 49.4万股 | +31.5万股+63.79% | 加仓 |
| Saturn V Capital Management LP |
| 1.36% | 2.49% | #4 | $949.9万 | 68.5万股 | $1,374.1万 | 51.7万股 | +16.8万股+32.53% | 加仓 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 0.86% | 1.86% | #6 | $889.1万 | 64.1万股 | $1,704.5万 | 64.1万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 0.18% | — | #9 | $866.9万 | 62.5万股 | $0 | 0股 | +62.5万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #32 | $859.8万 | 62.0万股 | $0 | 0股 | +62.0万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | 0.01% | #34 | $749.1万 | 54.0万股 | $3,578.3万 | 134.6万股 | -80.6万股-59.87% | 减仓 |
| PFM Health Sciences, LP |
| 0.52% | — | #7 | $604.8万 | 43.6万股 | $0 | 0股 | +43.6万股 | 新买入 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | — | #35 | $603.0万 | 43.5万股 | $0 | 0股 | +43.5万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | — | #27 | $553.4万 | 39.9万股 | $0 | 0股 | +39.9万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #26 | $547.7万 | 39.5万股 | $0 | 0股 | +39.5万股 | 新买入 |
| SYQUANT CAPITAL SAS |
| 1.18% | 0.93% | #5 | $520.1万 | 37.5万股 | $592.6万 | 22.3万股 | +15.2万股+68.26% | 加仓 |
| Nan Fung Group Holdings Ltd |
| 3.17% | 7.69% | #3 | $416.9万 | 30.1万股 | $932.6万 | 35.1万股 | -5.0万股-14.31% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #29 | $363.6万 | 26.2万股 | $54.5万 | 2.0万股 | +24.2万股+1,179.22% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #42 | $312.2万 | 22.5万股 | $11.3万 | 6,416股 | +21.9万股+3,408.15% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #30 | $305.7万 | 22.0万股 | $149.2万 | 5.6万股 | +16.4万股+292.69% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.01% | 0.02% | #24 | $286.2万 | 20.6万股 | $881.0万 | 33.1万股 | -12.5万股-37.73% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.02% | #22 | $279.1万 | 20.1万股 | $535.0万 | 20.1万股 | 00.00% | 持仓不变 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.05% | 0.01% | #14 | $266.3万 | 19.2万股 | $77.6万 | 2.9万股 | +16.3万股+557.66% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #41 | $253.0万 | 18.2万股 | $166.8万 | 6.3万股 | +12.0万股+190.72% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | 0.01% | #19 | $209.8万 | 15.1万股 | $117.6万 | 4.4万股 | +10.7万股+241.85% | 加仓 |
| 隆巴德·奥迪耶Compagnie Lombard Odier SCmA |
| 0.02% | 0.03% | #17 | $146.3万 | 10.5万股 | $280.4万 | 10.5万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #43 | $96.4万 | 7.0万股 | $180.2万 | 6.8万股 | +1,749股+2.58% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #36 | $91.0万 | 6.6万股 | $0 | 0股 | +6.6万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #37 | $85.4万 | 6.2万股 | $38.4万 | 1.4万股 | +4.7万股+326.42% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #46 | $84.9万 | 6.1万股 | $156.7万 | 5.9万股 | +2,299股+3.90% | 加仓 |
| ALPS顾问ALPS ADVISORS INC |
| <0.01% | 0.01% | #28 | $80.5万 | 5.8万股 | $123.7万 | 4.7万股 | +1.1万股+24.67% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #20 | $78.2万 | 5.6万股 | $66.4万 | 2.5万股 | +3.1万股+125.93% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #44 | $69.7万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #47 | $61.0万 | 4.4万股 | $185.5万 | 7.0万股 | -2.6万股-36.96% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #23 | $59.8万 | 4.3万股 | $61.2万 | 2.3万股 | +2.0万股+87.19% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | — | #25 | $55.1万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #39 | $43.0万 | 3.1万股 | $76.8万 | 2.9万股 | +2,127股+7.36% | 加仓 |
| Virtus Investment Advisers, LLC |
| 0.1% | — | #13 | $40.9万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| Persistent Asset Partners Ltd |
| 0.11% | — | #12 | $35.5万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #53 | $32.7万 | 2.4万股 | $50.5万 | 1.9万股 | +4,577股+24.09% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #50 | $32.5万 | 2.5万股 | $130.2万 | 5.3万股 | -2.8万股-53.16% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #48 | $28.6万 | 2.1万股 | $56.3万 | 2.1万股 | -566股-2.67% | 减仓 |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. |
| 0.01% | 0.04% | #18 | $24.0万 | 1.7万股 | $50.3万 | 1.9万股 | -1,650股-8.72% | 减仓 |
| Marble Bar Asset Management LLP |
| 0.14% | — | #11 | $20.5万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #52 | $15.6万 | 1.1万股 | $239.7万 | 9.0万股 | -7.9万股-87.51% | 减仓 |
| Quantbot Technologies LP |
| <0.01% | — | #31 | $7.4万 | 5,319股 | $0 | 0股 | +5,319股 | 新买入 |
| Aventura Private Wealth, LLC |
| 0.02% | 0.04% | #16 | $5.5万 | 4,000股 | $10.6万 | 4,000股 | 00.00% | 持仓不变 |
| 巴克莱BARCLAYS PLC |
| <0.01% | — | #54 | $4.5万 | 3,237股 | $0 | 0股 | +3,237股 | 新买入 |
| Wolverine资产管理WOLVERINE ASSET MANAGEMENT LLC |
| <0.01% | — | #40 | $4.1万 | 2,975股 | $0 | 0股 | +2,975股 | 新买入 |
