| GILEAD SCIENCES, INC. |
| 30.34% | 23.67% | #1 | $5.00亿 | 1,670.7万股 | $5.01亿 | 1,670.7万股 | 00.00% | 持仓不变 |
| TANG CAPITAL MANAGEMENT LLC |
| 5.16% | 5.77% | #3 | $1.14亿 | 378.6万股 | $1.14亿 | 378.6万股 | 00.00% | 持仓不变 |
| Madison Avenue Partners, LP |
| 4.45% | 3.22% | #4 | $1.03亿 | 344.8万股 | $7,395.5万 | 246.5万股 | +98.3万股+39.86% | 加仓 |
| Prosight Management, LP |
| 10.56% | 7.63% | #2 | $6,125.9万 | 204.3万股 | $4,650.0万 | 155.0万股 | +49.3万股+31.83% | 加仓 |
| EcoR1 Capital, LLC |
| 2.43% | 2.12% | #5 | $4,998.0万 | 166.7万股 | $5,001.4万 | 166.7万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.01% | 0.01% | #16 | $3,814.1万 | 127.2万股 | $4,274.0万 | 142.5万股 | -15.2万股-10.70% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #26 | $1,801.8万 | 60.1万股 | $1,388.1万 | 46.3万股 | +13.8万股+29.89% | 加仓 |
| DME 资本管理DME Capital Management, LP |
| 0.37% | 0.45% | #7 | $1,447.3万 | 48.3万股 | $1,448.2万 | 48.3万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.01% | #12 | $1,222.6万 | 40.8万股 | $946.2万 | 31.5万股 | +9.2万股+29.30% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #46 | $1,013.8万 | 33.8万股 | $936.3万 | 31.2万股 | +2.6万股+8.35% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #15 | $808.9万 | 27.0万股 | $996.4万 | 33.2万股 | -6.2万股-18.76% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #22 | $593.1万 | 19.8万股 | $647.2万 | 21.6万股 | -1.8万股-8.29% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $542.9万 | 18.1万股 | $323.7万 | 10.8万股 | +7.3万股+67.81% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #34 | $504.1万 | 16.8万股 | $525.9万 | 17.5万股 | -7,141股-4.07% | 减仓 |
| DAFNA Capital Management LLC |
| 0.74% | 0.89% | #6 | $390.3万 | 13.0万股 | $390.5万 | 13.0万股 | 00.00% | 持仓不变 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #41 | $264.9万 | 8.8万股 | $440.5万 | 14.7万股 | -5.8万股-39.83% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #24 | $245.1万 | 8.2万股 | $77.6万 | 2.6万股 | +5.6万股+216.12% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | <0.01% | #42 | $230.5万 | 7.7万股 | $301.4万 | 12.0万股 | -4.3万股-35.93% | 减仓 |
| ALPS顾问ALPS ADVISORS INC |
| 0.01% | 0.01% | #14 | $196.4万 | 6.6万股 | $161.0万 | 5.4万股 | +1.2万股+22.11% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #48 | $169.6万 | 5.7万股 | $136.1万 | 4.5万股 | +1.1万股+24.71% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #36 | $122.3万 | 4.1万股 | $116.4万 | 3.9万股 | +2,014股+5.19% | 加仓 |
| BAROMETER CAPITAL MANAGEMENT INC. |
| 0.34% | 0.39% | #8 | $122.3万 | 4.1万股 | $114.3万 | 3.8万股 | +2,700股+7.09% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #55 | $113.0万 | 3.8万股 | $221.9万 | 6.4万股 | -2.6万股-41.18% | 减仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| <0.01% | — | #20 | $97.7万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #31 | $97.1万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| Monaco Asset Management SAM |
| 0.06% | 0.15% | #10 | $76.7万 | 2.6万股 | $82.6万 | 2.8万股 | -1,920股-6.98% | 减仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #30 | $71.1万 | 2.4万股 | $137.3万 | 4.6万股 | -2.2万股-48.41% | 减仓 |
| denkapparat Operations GmbH |
| 0.21% | 0.13% | #9 | $63.9万 | 2.1万股 | $31.9万 | 1.1万股 | +1.1万股+100.49% | 加仓 |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.04% | 0.04% | #11 | $57.9万 | 1.9万股 | $57.9万 | 1.9万股 | 00.00% | 持仓不变 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #33 | $52.7万 | 1.8万股 | $15.2万 | 5,082股 | +1.2万股+245.87% | 加仓 |
| QRG资本管理QRG CAPITAL MANAGEMENT, INC. |
| <0.01% | 0.01% | #17 | $52.6万 | 1.8万股 | $59.1万 | 2.0万股 | -2,159股-10.96% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | <0.01% | #29 | $51.9万 | 1.7万股 | $135.5万 | 4.5万股 | -2.8万股-61.64% | 减仓 |
| 奥地利Erste资产管理Erste Asset Management GmbH |
| <0.01% | <0.01% | #21 | $41.5万 | 1.4万股 | $40.4万 | 1.4万股 | 00.00% | 持仓不变 |
| Commonwealth股权服务COMMONWEALTH EQUITY SERVICES, LLC |
| <0.01% | <0.01% | #37 | $34.3万 | 1.1万股 | $31.5万 | 1.0万股 | +952股+9.07% | 加仓 |
| 十字标全球控股Crossmark Global Holdings, Inc. |
| <0.01% | 0.01% | #19 | $31.6万 | 1.1万股 | $97.8万 | 3.3万股 | -2.2万股-67.68% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #63 | $30.4万 | 1.0万股 | $30.5万 | 1.0万股 | 00.00% | 持仓不变 |
| Cerity合伙人Cerity Partners LLC |
| <0.01% | <0.01% | #38 | $30.0万 | 1.0万股 | $30.9万 | 1.0万股 | -310股-3.01% | 减仓 |
| Aquatic 资本管理Aquatic Capital Management LLC |
| 0.01% | 0.01% | #13 | $27.3万 | 9,109股 | $35.6万 | 1.2万股 | -2,750股-23.19% | 减仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #45 | $25.0万 | 8,323股 | $21.7万 | 7,227股 | +1,096股+15.17% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #64 | $22.6万 | 7,529股 | $62.2万 | 2.1万股 | -1.3万股-63.67% | 减仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #44 | $21.9万 | 7,297股 | $22.1万 | 7,381股 | -84股-1.14% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #50 | $20.7万 | 6,896股 | $33.9万 | 1.1万股 | -4,396股-38.93% | 减仓 |
| China Universal Asset Management Co., Ltd. |
| <0.01% | 0.01% | #18 | $7.2万 | 2,393股 | $7.9万 | 2,631股 | -238股-9.05% | 减仓 |
| SignatureFD财富SIGNATUREFD, LLC |
| <0.01% | <0.01% | #32 | $5.6万 | 1,852股 | $4.8万 | 1,611股 | +241股+14.96% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #73 | $3.9万 | 1,320股 | $4,326 | 150股 | +1,170股+780.00% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #67 | $3.6万 | 1,200股 | $3.6万 | 1,200股 | 00.00% | 持仓不变 |
| Arax顾问Arax Advisory Partners |
| <0.01% | <0.01% | #43 | $3.0万 | 1,009股 | $2.6万 | 874股 | +135股+15.45% | 加仓 |
| CACTI ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #25 | $3.0万 | 1,000股 | $3.0万 | 1,000股 | 00.00% | 持仓不变 |
| GAMMA Investing LLC |
| <0.01% | <0.01% | #27 | $2.9万 | 954股 | $6.0万 | 2,005股 | -1,051股-52.42% | 减仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #69 | $2.6万 | 867股 | $2.0万 | 661股 | +206股+31.16% | 加仓 |
