| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.07% | 0.09% | #8 | $805.8万 | 93.3万股 | $805.4万 | 118.3万股 | -25.0万股-21.14% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.14% | 0.14% | #7 | $729.9万 | 84.5万股 | $700.0万 | 102.8万股 | -18.3万股-17.82% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #25 | $541.4万 | 62.7万股 | $426.7万 | 62.7万股 | 00.00% | 持仓不变 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #29 | $402.8万 | 46.6万股 | $260.0万 | 38.2万股 | +8.4万股+22.11% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $296.5万 | 34.3万股 | $229.2万 | 33.7万股 | +6,704股+1.99% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #20 | $237.1万 | 27.4万股 | $186.8万 | 27.4万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #21 | $229.8万 | 26.6万股 | $158.4万 | 23.3万股 | +3.3万股+14.34% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.32% | 0.61% | #3 | $212.1万 | 24.6万股 | $151.2万 | 22.2万股 | +2.4万股+10.62% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #18 | $176.1万 | 20.4万股 | $138.8万 | 20.4万股 | 00.00% | 持仓不变 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.01% | — | #17 | $168.9万 | 19.6万股 | $0 | 0股 | +19.6万股 | 新买入 |
| 凯雷集团Carlyle Group Inc. |
| 0.02% | 0.01% | #11 | $159.2万 | 18.4万股 | $125.5万 | 18.4万股 | 00.00% | 持仓不变 |
| NEXTBio Capital Management LP |
| 0.63% | 0.5% | #1 | $136.4万 | 15.8万股 | $107.5万 | 15.8万股 | 00.00% | 持仓不变 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #24 | $107.9万 | 12.5万股 | $80.2万 | 11.8万股 | +6,694股+5.67% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $83.7万 | 9.7万股 | $29.4万 | 4.3万股 | +5.4万股+124.65% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $82.7万 | 9.6万股 | $68.9万 | 10.1万股 | -5,501股-5.44% | 减仓 |
| DAFNA Capital Management LLC |
| 0.15% | 0.15% | #6 | $81.1万 | 9.4万股 | $63.9万 | 9.4万股 | 00.00% | 持仓不变 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | — | #13 | $74.3万 | 8.6万股 | $0 | 0股 | +8.6万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #28 | $68.7万 | 7.9万股 | $0 | 0股 | +7.9万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| <0.01% | <0.01% | #19 | $67.4万 | 7.8万股 | $29.7万 | 4.4万股 | +3.4万股+78.63% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #38 | $61.0万 | 7.1万股 | $25.3万 | 3.7万股 | +3.3万股+90.27% | 加仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.02% | 0.02% | #10 | $54.0万 | 6.3万股 | $42.6万 | 6.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #47 | $53.7万 | 6.2万股 | $24.9万 | 3.7万股 | +2.6万股+69.81% | 加仓 |
| REGENERON PHARMACEUTICALS, INC. |
| 0.3% | 0.86% | #4 | $52.3万 | 6.1万股 | $41.2万 | 6.1万股 | 00.00% | 持仓不变 |
| Rangeley Capital, LLC |
| 0.42% | 0.37% | #2 | $44.0万 | 5.1万股 | $38.1万 | 5.6万股 | -5,108股-9.12% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #34 | $43.8万 | 5.1万股 | $34.3万 | 5.0万股 | +336股+0.67% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #42 | $34.8万 | 4.0万股 | $36.0万 | 5.3万股 | -1.3万股-23.91% | 减仓 |
| RBF Capital, LLC |
| 0.01% | 0.01% | #12 | $33.3万 | 3.9万股 | $26.3万 | 3.9万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #46 | $31.3万 | 3.6万股 | $24.7万 | 3.6万股 | 00.00% | 持仓不变 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #23 | $31.3万 | 3.6万股 | $0 | 0股 | +3.6万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #39 | $27.3万 | 3.2万股 | $7.3万 | 1.1万股 | +2.1万股+193.22% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #41 | $25.8万 | 3.0万股 | $26.1万 | 3.8万股 | -8,551股-22.29% | 减仓 |
| Verdad Advisers, LP |
| 0.21% | — | #5 | $21.8万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #22 | $21.0万 | 2.4万股 | $13.0万 | 1.9万股 | +5,158股+26.97% | 加仓 |
| JOHNSON & JOHNSON |
| 0.02% | 0.02% | #9 | $19.7万 | 2.3万股 | $15.5万 | 2.3万股 | 00.00% | 持仓不变 |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.01% | — | #14 | $16.0万 | 1.9万股 | $0 | 0股 | +1.9万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #45 | $15.9万 | 1.8万股 | $13.1万 | 1.9万股 | -764股-3.98% | 减仓 |
| OCCUDO QUANTITATIVE STRATEGIES LP |
| 0.01% | 0.01% | #16 | $14.4万 | 1.7万股 | $11.4万 | 1.5万股 | +1,536股+10.17% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #33 | $13.2万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 冯托贝尔控股Vontobel Holding Ltd. |
| <0.01% | <0.01% | #31 | $11.9万 | 1.4万股 | $9.7万 | 1.4万股 | -471股-3.31% | 减仓 |
| AXQ CAPITAL, LP |
| 0.01% | — | #15 | $9.5万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | — | #26 | $9.5万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| Arax顾问Arax Advisory Partners |
| <0.01% | — | #32 | $5.2万 | 6,000股 | $0 | 0股 | +6,000股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #44 | $4.5万 | 5,221股 | $3.6万 | 5,221股 | 00.00% | 持仓不变 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #43 | $4.2万 | 4,814股 | $9,486 | 1,393股 | +3,421股+245.59% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #51 | $2.0万 | 2,291股 | $6.0万 | 7.4万股 | -7.1万股-96.89% | 减仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #50 | $1.5万 | 1,701股 | $1.1万 | 1,687股 | +14股+0.83% | 加仓 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #49 | $2,592 | 300股 | $681 | 100股 | +200股+200.00% | 加仓 |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #36 | $2,393 | 277股 | $9,677 | 1,421股 | -1,144股-80.51% | 减仓 |
| Avion Wealth |
| <0.01% | <0.01% | #30 | $2,125 | 246股 | $1,000 | 246股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #54 | $1,677 | 196股 | $49 | 8股 | +188股+2,350.00% | 加仓 |
