| GordonMD Global Investments LP |
| 14.98% | 25.51% | #1 | $3,782.1万 | 424.5万股 | $3,663.3万 | 424.5万股 | 00.00% | 持仓不变 |
| GILEAD SCIENCES, INC. |
| 2.23% | 1.68% | #4 | $3,676.4万 | 412.6万股 | $3,560.8万 | 412.6万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #65 | $2,793.1万 | 313.5万股 | $756.9万 | 87.7万股 | +225.8万股+257.41% | 加仓 |
| Bain Capital Life Sciences Investors, LLC |
| 1.53% | 2.42% | #6 | $2,570.5万 | 288.5万股 | $2,683.9万 | 311.0万股 | -22.5万股-7.23% | 减仓 |
| AIGH Capital Management LLC |
| 1.57% | 2.35% | #5 | $2,491.1万 | 279.6万股 | $1,726.0万 | 200.0万股 | +79.6万股+39.79% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.19% | 0.2% | #12 | $1,782.0万 | 200.0万股 | $1,726.0万 | 200.0万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #68 | $1,690.6万 | 189.7万股 | $1,539.0万 | 178.3万股 | +11.4万股+6.40% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #46 | $1,056.7万 | 118.6万股 | $1,342.3万 | 155.5万股 | -36.9万股-23.74% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #60 | $935.3万 | 104.9万股 | $366.0万 | 42.4万股 | +62.6万股+147.61% | 加仓 |
| Insight Holdings Group, LLC |
| 0.67% | 0.6% | #7 | $881.2万 | 98.9万股 | $853.6万 | 98.9万股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #62 | $875.2万 | 98.2万股 | $104.5万 | 17.4万股 | +80.8万股+463.89% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #76 | $875.2万 | 98.2万股 | $119.4万 | 13.8万股 | +84.4万股+610.22% | 加仓 |
| Propel Bio Management, LLC |
| 4.12% | 3.52% | #3 | $786.9万 | 88.3万股 | $558.6万 | 64.4万股 | +23.9万股+37.05% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.03% | #20 | $753.2万 | 84.5万股 | $729.5万 | 84.5万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $570.0万 | 64.0万股 | $867.8万 | 100.6万股 | -36.6万股-36.37% | 减仓 |
| MBB PUBLIC MARKETS I LLC |
| 0.59% | 0.63% | #8 | $547.5万 | 61.4万股 | $530.3万 | 61.4万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #30 | $445.5万 | 50.0万股 | $431.5万 | 50.0万股 | 00.00% | 持仓不变 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #38 | $418.2万 | 46.9万股 | $622.7万 | 72.2万股 | -25.2万股-34.96% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #57 | $332.4万 | 37.3万股 | $98.7万 | 11.4万股 | +25.9万股+226.06% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #64 | $325.7万 | 36.6万股 | $388.1万 | 45.0万股 | -8.4万股-18.72% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $298.7万 | 33.5万股 | $183.7万 | 21.3万股 | +12.2万股+57.45% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #33 | $297.5万 | 33.4万股 | $317.1万 | 36.7万股 | -3.4万股-9.14% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #71 | $286.8万 | 32.2万股 | $75.6万 | 8.8万股 | +23.4万股+267.39% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #67 | $284.8万 | 32.0万股 | $182.2万 | 21.1万股 | +10.9万股+51.44% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #72 | $281.0万 | 31.5万股 | $67.4万 | 7.8万股 | +23.7万股+304.08% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #40 | $276.8万 | 31.1万股 | $355.6万 | 41.2万股 | -10.1万股-24.61% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #93 | $251.4万 | 28.2万股 | $0 | 0股 | +28.2万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #85 | $236.5万 | 26.5万股 | $48.1万 | 5.6万股 | +21.0万股+376.25% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #59 | $231.4万 | 26.0万股 | $193.8万 | 22.5万股 | +3.5万股+15.62% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #83 | $219.5万 | 24.6万股 | $546.6万 | 63.3万股 | -38.7万股-61.10% | 减仓 |
| Walleye资本Walleye Capital LLC |
| 0.01% | <0.01% | #26 | $218.8万 | 24.6万股 | $33.0万 | 3.8万股 | +20.7万股+542.97% | 加仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.04% | 0.02% | #15 | $216.0万 | 24.2万股 | $99.1万 | 11.5万股 | +12.8万股+111.06% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #61 | $208.3万 | 23.4万股 | $0 | 0股 | +23.4万股 | 新买入 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.06% | 0.09% | #13 | $178.2万 | 20.0万股 | $172.6万 | 20.0万股 | 00.00% | 持仓不变 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.02% | 0.02% | #21 | $162.7万 | 18.3万股 | $149.4万 | 17.3万股 | +9,497股+5.49% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.03% | #19 | $133.6万 | 15.0万股 | $129.4万 | 15.0万股 | 00.00% | 持仓不变 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #44 | $129.8万 | 14.6万股 | $145.9万 | 16.9万股 | -2.3万股-13.84% | 减仓 |
| Stifel金融STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #47 | $124.7万 | 14.0万股 | $112.6万 | 13.1万股 | +9,441股+7.23% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #49 | $110.2万 | 12.4万股 | $288.0万 | 33.4万股 | -21.0万股-62.95% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #80 | $105.0万 | 11.8万股 | $117.7万 | 13.6万股 | -1.9万股-13.59% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #82 | $104.6万 | 11.7万股 | $0 | 0股 | +11.7万股 | 新买入 |
| WESBANCO 银行WESBANCO BANK INC |
| 0.02% | 0.03% | #18 | $98.3万 | 11.0万股 | $95.2万 | 11.0万股 | 00.00% | 持仓不变 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | 0.01% | #29 | $90.3万 | 10.1万股 | $45.5万 | 5.3万股 | +4.9万股+92.09% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #86 | $89.4万 | 10.0万股 | $0 | 0股 | +10.0万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #106 | $85.6万 | 9.6万股 | $5.9万 | 6,811股 | +8.9万股+1,310.23% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | 0.01% | #45 | $85.6万 | 9.6万股 | $971.2万 | 112.5万股 | -102.9万股-91.46% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.01% | <0.01% | #23 | $79.2万 | 8.9万股 | $24.0万 | 2.8万股 | +6.1万股+219.06% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #53 | $73.8万 | 8.3万股 | $126.8万 | 14.7万股 | -6.4万股-43.62% | 减仓 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #56 | $73.2万 | 8.2万股 | $116.1万 | 13.5万股 | -5.2万股-38.89% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #90 | $69.9万 | 7.8万股 | $67.7万 | 7.8万股 | 00.00% | 持仓不变 |
