| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.16% | 0.18% | #14 | $1,823.2万 | 399.8万股 | $1,655.3万 | 399.8万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 0.38% | 0.26% | #9 | $1,475.5万 | 323.6万股 | $819.3万 | 197.9万股 | +125.7万股+63.51% | 加仓 |
| ACORN CAPITAL ADVISORS, LLC |
| 3.53% | 3.34% | #2 | $1,294.9万 | 284.0万股 | $1,175.6万 | 284.0万股 | 00.00% | 持仓不变 |
| StepStone Group LP |
| 4.82% | 5.31% | #1 | $1,101.5万 | 266.1万股 | $1,101.5万 | 266.1万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.47% | 0.59% | #7 | $1,020.8万 | 223.9万股 | $1,008.1万 | 243.5万股 | -19.6万股-8.06% | 减仓 |
| Vivo Capital, LLC |
| 0.8% | 0.66% | #5 | $879.0万 | 192.8万股 | $798.1万 | 192.8万股 | 00.00% | 持仓不变 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.19% | 0.21% | #10 | $832.5万 | 182.6万股 | $761.7万 | 184.0万股 | -1.4万股-0.77% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #47 | $683.9万 | 150.0万股 | $20.5万 | 5.0万股 | +145.0万股+2,924.67% | 加仓 |
| Trails Edge Capital Partners, LP |
| 1.04% | — | #3 | $655.9万 | 143.8万股 | $0 | 0股 | +143.8万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #44 | $655.3万 | 143.7万股 | $241.1万 | 58.2万股 | +85.5万股+146.71% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #27 | $549.4万 | 120.5万股 | $498.8万 | 120.5万股 | 00.00% | 持仓不变 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #36 | $541.3万 | 118.7万股 | $15.6万 | 3.8万股 | +114.9万股+3,058.13% | 加仓 |
| Sio Capital Management, LLC |
| 0.81% | 0.64% | #4 | $492.0万 | 107.9万股 | $446.7万 | 107.9万股 | 00.00% | 持仓不变 |
| Prosight Management, LP |
| 0.77% | 1.46% | #6 | $446.4万 | 97.9万股 | $891.9万 | 215.4万股 | -117.5万股-54.56% | 减仓 |
| Logos Global Management LP |
| 0.19% | — | #11 | $439.5万 | 96.4万股 | $0 | 0股 | +96.4万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $330.3万 | 72.4万股 | $40.9万 | 9.9万股 | +62.6万股+633.61% | 加仓 |
| NEA Management Company, LLC |
| 0.14% | 0.11% | #16 | $218.2万 | 47.9万股 | $198.1万 | 47.9万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #50 | $211.4万 | 46.4万股 | $5.6万 | 1.3万股 | +45.0万股+3,344.23% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | — | #30 | $196.8万 | 43.2万股 | $0 | 0股 | +43.2万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #31 | $163.6万 | 35.9万股 | $156.2万 | 37.7万股 | -1.9万股-4.91% | 减仓 |
| Sofinnova Investments, Inc. |
| 0.08% | 0.02% | #21 | $146.7万 | 32.2万股 | $58.7万 | 14.2万股 | +18.0万股+127.02% | 加仓 |
| 凯雷集团Carlyle Group Inc. |
| 0.01% | 0.01% | #25 | $123.1万 | 27.0万股 | $111.7万 | 27.0万股 | 00.00% | 持仓不变 |
| Affinity Asset Advisors, LLC |
| 0.05% | 0.05% | #22 | $109.9万 | 24.1万股 | $99.8万 | 24.1万股 | 00.00% | 持仓不变 |
| DV EQUITIES, LLC |
| 0.16% | — | #15 | $109.9万 | 24.1万股 | $0 | 0股 | +24.1万股 | 新买入 |
| Seven Fleet Capital Management LP |
| 0.18% | — | #12 | $109.9万 | 24.1万股 | $0 | 0股 | +24.1万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #45 | $89.9万 | 19.7万股 | $8.2万 | 2.0万股 | +17.7万股+890.69% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #61 | $81.1万 | 17.8万股 | $0 | 0股 | +17.8万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #43 | $75.3万 | 16.5万股 | $18.0万 | 4.3万股 | +12.2万股+280.85% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #37 | $72.9万 | 16.0万股 | $15.1万 | 3.6万股 | +12.3万股+338.70% | 加仓 |
| Rosalind Advisors, Inc. |
| 0.16% | 0.74% | #13 | $68.4万 | 15.0万股 | $183.7万 | 44.4万股 | -29.4万股-66.20% | 减仓 |
| Stonepine Capital Management, LLC |
| 0.09% | 0.22% | #19 | $59.6万 | 13.1万股 | $54.9万 | 13.3万股 | -1,894股-1.43% | 减仓 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.01% | — | #26 | $54.9万 | 12.0万股 | $0 | 0股 | +12.0万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #38 | $49.6万 | 10.9万股 | $10.0万 | 2.4万股 | +8.5万股+348.73% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #63 | $48.5万 | 10.6万股 | $0 | 0股 | +10.6万股 | 新买入 |
| 康托·菲茨杰拉德CANTOR FITZGERALD, L. P. |
| <0.01% | 0.01% | #28 | $45.6万 | 10.0万股 | $41.4万 | 10.0万股 | +114股+0.11% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #51 | $45.4万 | 10.0万股 | $1.4万 | 3,395股 | +9.6万股+2,833.84% | 加仓 |
| Rangeley Capital, LLC |
| 0.41% | 0.38% | #8 | $43.3万 | 9.5万股 | $39.3万 | 9.5万股 | 00.00% | 持仓不变 |
| Aisling Capital Management LP |
| 0.09% | 0.08% | #20 | $40.4万 | 8.9万股 | $36.7万 | 8.9万股 | 00.00% | 持仓不变 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #53 | $32.9万 | 7.2万股 | $0 | 0股 | +7.2万股 | 新买入 |
| Walleye资本Walleye Capital LLC |
| <0.01% | — | #32 | $32.4万 | 7.1万股 | $0 | 0股 | +7.1万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #52 | $31.2万 | 6.9万股 | $0 | 0股 | +6.9万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #59 | $29.0万 | 6.4万股 | $0 | 0股 | +6.4万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #29 | $22.9万 | 5.0万股 | $6.7万 | 1.6万股 | +3.4万股+208.68% | 加仓 |
| Shay Capital LLC |
| 0.01% | 0.05% | #24 | $22.8万 | 5.0万股 | $54.7万 | 13.2万股 | -8.2万股-62.18% | 减仓 |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.01% | — | #23 | $21.3万 | 4.7万股 | $0 | 0股 | +4.7万股 | 新买入 |
| Aldebaran Capital, LLC |
| 0.14% | 0.13% | #17 | $18.2万 | 4.0万股 | $16.7万 | 4.0万股 | -550股-1.36% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #65 | $16.6万 | 3.6万股 | $5.6万 | 1.4万股 | +2.3万股+170.01% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #60 | $16.1万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #64 | $14.5万 | 3.2万股 | $10.4万 | 2.5万股 | +6,720股+26.88% | 加仓 |
| Verdad Advisers, LP |
| 0.13% | — | #18 | $13.1万 | 2.9万股 | $0 | 0股 | +2.9万股 | 新买入 |
