| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 1.02% | 1.38% | #9 | $5,571.4万 | 944.3万股 | $5,394.9万 | 906.7万股 | +37.6万股+4.15% | 加仓 |
| Venrock Adviser, LLC |
| 1.15% | 1.43% | #6 | $3,796.6万 | 643.5万股 | $3,828.8万 | 643.5万股 | 00.00% | 持仓不变 |
| MPM BioImpact LLC |
| 1.61% | — | #5 | $2,639.0万 | 447.3万股 | $0 | 0股 | +447.3万股 | 新买入 |
| GREAT POINT PARTNERS LLC |
| 4.7% | 5.77% | #1 | $2,487.4万 | 421.6万股 | $2,508.5万 | 421.6万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #38 | $2,451.7万 | 435.5万股 | $2,532.6万 | 445.9万股 | -10.4万股-2.34% | 减仓 |
| BRAIDWELL LP |
| 0.87% | 0.79% | #10 | $2,348.4万 | 398.0万股 | $2,373.4万 | 398.9万股 | -8,694股-0.22% | 减仓 |
| Siren, L.L.C. |
| 0.45% | 0.62% | #14 | $2,203.6万 | 373.5万股 | $2,222.2万 | 373.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $2,132.7万 | 361.5万股 | $272.1万 | 45.7万股 | +315.7万股+690.34% | 加仓 |
| Commodore Capital LP |
| 1.14% | 1.12% | #8 | $1,917.5万 | 325.0万股 | $1,933.8万 | 325.0万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.03% | #25 | $1,622.5万 | 275.0万股 | $1,636.3万 | 275.0万股 | 00.00% | 持仓不变 |
| Saturn V Capital Management LP |
| 1.78% | 0.8% | #2 | $1,239.7万 | 210.1万股 | $440.3万 | 74.0万股 | +136.1万股+183.95% | 加仓 |
| QVT Financial LP |
| 0.66% | 0.57% | #12 | $1,118.1万 | 189.5万股 | $779.8万 | 131.1万股 | +58.5万股+44.60% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.48% | 0.22% | #13 | $1,038.0万 | 175.9万股 | $375.1万 | 63.0万股 | +112.9万股+179.07% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.12% | 0.16% | #22 | $965.2万 | 163.6万股 | $896.7万 | 150.7万股 | +12.9万股+8.56% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #43 | $934.9万 | 158.4万股 | $314.1万 | 52.8万股 | +105.7万股+200.22% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.39% | 0.79% | #17 | $863.9万 | 146.4万股 | $1,525.8万 | 256.4万股 | -110.0万股-42.90% | 减仓 |
| STEMPOINT CAPITAL LP |
| 1.15% | 0.83% | #7 | $807.2万 | 136.8万股 | $448.3万 | 75.4万股 | +61.5万股+81.58% | 加仓 |
| Ikarian Capital, LLC |
| 0.76% | 0.58% | #11 | $718.9万 | 121.8万股 | $710.1万 | 119.3万股 | +2.5万股+2.09% | 加仓 |
| EcoR1 Capital, LLC |
| 0.34% | 0.3% | #19 | $696.0万 | 118.0万股 | $701.9万 | 118.0万股 | 00.00% | 持仓不变 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.16% | 0.09% | #21 | $692.6万 | 117.4万股 | $304.0万 | 51.1万股 | +66.3万股+129.74% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #57 | $591.0万 | 100.2万股 | $116.0万 | 19.5万股 | +80.7万股+413.76% | 加仓 |
| Boxer Capital Management, LLC |
| 0.4% | 0.7% | #16 | $531.0万 | 90.0万股 | $535.5万 | 90.0万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #71 | $440.9万 | 74.7万股 | $289.7万 | 48.7万股 | +26.1万股+53.51% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #49 | $338.6万 | 57.4万股 | $91.0万 | 15.3万股 | +42.1万股+275.34% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #64 | $311.7万 | 52.8万股 | $315.0万 | 52.9万股 | -1,062股-0.20% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #60 | $298.5万 | 50.6万股 | $90.7万 | 20.9万股 | +29.7万股+141.59% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #46 | $295.1万 | 50.0万股 | $62.0万 | 10.4万股 | +39.6万股+380.25% | 加仓 |
| PFIZER INC |
| 1.69% | 7.05% | #3 | $288.3万 | 53.9万股 | $1,683.5万 | 283.9万股 | -230.0万股-81.02% | 减仓 |
| Foresite Capital Management VI LLC |
| 0.41% | 0.58% | #15 | $265.5万 | 45.0万股 | $267.8万 | 45.0万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #67 | $240.4万 | 40.8万股 | $0 | 0股 | +40.8万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #42 | $239.8万 | 40.6万股 | $138.0万 | 23.2万股 | +17.5万股+75.30% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.03% | #24 | $223.7万 | 37.9万股 | $222.8万 | 37.5万股 | +4,671股+1.25% | 加仓 |
| KVP Capital Advisors, LP |
| 1.62% | 1.66% | #4 | $220.1万 | 37.3万股 | $222.0万 | 37.3万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #37 | $207.0万 | 35.1万股 | $189.3万 | 31.8万股 | +3.3万股+10.28% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #36 | $189.8万 | 32.2万股 | $186.4万 | 31.3万股 | +8,402股+2.68% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #52 | $177.4万 | 30.1万股 | $19.1万 | 3.2万股 | +26.9万股+836.88% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #47 | $166.5万 | 28.2万股 | $0 | 0股 | +28.2万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #53 | $156.5万 | 26.5万股 | $143.4万 | 24.1万股 | +2.4万股+10.08% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | <0.01% | #28 | $136.6万 | 23.2万股 | $16.7万 | 2.8万股 | +20.4万股+725.29% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #63 | $102.9万 | 17.4万股 | $18.5万 | 3.1万股 | +14.3万股+460.83% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #51 | $81.2万 | 13.8万股 | $897.3万 | 150.8万股 | -137.0万股-90.87% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #29 | $80.4万 | 13.6万股 | $71.2万 | 12.0万股 | +1.7万股+13.79% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #74 | $79.8万 | 13.5万股 | $186.1万 | 31.3万股 | -17.7万股-56.74% | 减仓 |
| 阿尔伯塔投资管理(AIMCo)Alberta Investment Management Corp |
| <0.01% | <0.01% | #34 | $78.6万 | 13.3万股 | $79.3万 | 13.3万股 | 00.00% | 持仓不变 |
| 纽文Nuveen, LLC |
| <0.01% | — | #56 | $74.5万 | 12.6万股 | $0 | 0股 | +12.6万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #65 | $73.4万 | 12.4万股 | $0 | 0股 | +12.4万股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #66 | $62.4万 | 10.6万股 | $101.1万 | 17.0万股 | -6.4万股-37.74% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #83 | $57.2万 | 9.7万股 | $81.2万 | 13.7万股 | -3.9万股-28.93% | 减仓 |
| ALPS顾问ALPS ADVISORS INC |
| <0.01% | <0.01% | #35 | $56.9万 | 9.6万股 | $41.8万 | 7.0万股 | +2.6万股+37.36% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #30 | $50.4万 | 8.5万股 | $50.8万 | 8.5万股 | 00.00% | 持仓不变 |
