| Venrock Adviser, LLC |
| 0.77% | 0.69% | #9 | $2,545.9万 | 385.2万股 | $1,848.8万 | 385.2万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.41% | 0.36% | #11 | $2,162.4万 | 327.1万股 | $1,839.8万 | 383.3万股 | -56.1万股-14.65% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.01% | #27 | $2,022.7万 | 306.0万股 | $336.0万 | 70.0万股 | +236.0万股+337.14% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #37 | $1,772.9万 | 268.2万股 | $1,159.6万 | 241.6万股 | +26.6万股+11.02% | 加仓 |
| Rosalind Advisors, Inc. |
| 3.06% | 2.95% | #2 | $1,293.5万 | 195.7万股 | $735.3万 | 153.2万股 | +42.5万股+27.74% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 1.4% | 0.75% | #6 | $1,071.3万 | 162.1万股 | $473.8万 | 98.7万股 | +63.4万股+64.20% | 加仓 |
| ACORN CAPITAL ADVISORS, LLC |
| 2.78% | 2.1% | #3 | $1,018.1万 | 154.0万股 | $739.3万 | 154.0万股 | 00.00% | 持仓不变 |
| DCF Advisers, LLC |
| 1.68% | 0.89% | #4 | $948.5万 | 143.5万股 | $332.2万 | 69.2万股 | +74.3万股+107.37% | 加仓 |
| Sio Capital Management, LLC |
| 1.42% | — | #5 | $859.3万 | 130.0万股 | $0 | 0股 | +130.0万股 | 新买入 |
| Nan Fung Group Holdings Ltd |
| 4.96% | 1.82% | #1 | $652.6万 | 98.7万股 | $220.8万 | 46.0万股 | +52.7万股+114.61% | 加仓 |
| Boxer Capital Management, LLC |
| 0.39% | 0.4% | #12 | $522.2万 | 79.0万股 | $307.2万 | 64.0万股 | +15.0万股+23.44% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #55 | $515.1万 | 77.9万股 | $439.5万 | 91.6万股 | -13.6万股-14.90% | 减仓 |
| Logos Global Management LP |
| 0.21% | — | #16 | $495.8万 | 75.0万股 | $0 | 0股 | +75.0万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #59 | $387.4万 | 58.6万股 | $239.2万 | 49.8万股 | +8.8万股+17.60% | 加仓 |
| DAFNA Capital Management LLC |
| 0.65% | 0.54% | #10 | $339.8万 | 51.4万股 | $239.2万 | 49.8万股 | +1.6万股+3.15% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.01% | — | #32 | $332.2万 | 50.3万股 | $0 | 0股 | +50.3万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #67 | $305.3万 | 46.2万股 | $134.1万 | 22.8万股 | +23.4万股+102.88% | 加仓 |
| Knott David M Jr |
| 1.3% | 1.02% | #7 | $244.6万 | 37.0万股 | $168.0万 | 35.0万股 | +2.0万股+5.71% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.35% | 0.26% | #13 | $231.4万 | 33.1万股 | $64.3万 | 13.4万股 | +19.6万股+146.55% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #64 | $231.3万 | 35.0万股 | $51.0万 | 10.6万股 | +24.4万股+229.01% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #69 | $223.0万 | 33.7万股 | $0 | 0股 | +33.7万股 | 新买入 |
| DIADEMA PARTNERS LP |
| 0.24% | — | #14 | $198.3万 | 30.0万股 | $0 | 0股 | +30.0万股 | 新买入 |
| AdvisorShares Investments LLC |
| 0.23% | 0.17% | #15 | $193.5万 | 29.3万股 | $93.9万 | 19.6万股 | +9.7万股+49.64% | 加仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #50 | $178.0万 | 26.9万股 | $53.4万 | 11.1万股 | +15.8万股+141.96% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #72 | $163.6万 | 23.8万股 | $9,694 | 2,244股 | +23.6万股+10,498.40% | 加仓 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.01% | 0.01% | #31 | $153.4万 | 23.2万股 | $74.4万 | 15.5万股 | +7.7万股+49.68% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #66 | $144.6万 | 21.9万股 | $114.4万 | 23.8万股 | -2.0万股-8.21% | 减仓 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 0.85% | — | #8 | $135.1万 | 20.4万股 | $0 | 0股 | +20.4万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #46 | $126.4万 | 19.1万股 | $0 | 0股 | +19.1万股 | 新买入 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #47 | $110.8万 | 16.8万股 | $1.7万 | 3,462股 | +16.4万股+4,741.13% | 加仓 |
| Pale Fire Capital SE |
| 0.07% | 0.06% | #23 | $101.5万 | 15.4万股 | $73.7万 | 15.4万股 | 00.00% | 持仓不变 |
| PDT Partners, LLC |
| 0.05% | — | #25 | $99.3万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
| Eversept Partners, LP |
| 0.05% | — | #26 | $96.8万 | 14.6万股 | $0 | 0股 | +14.6万股 | 新买入 |
| Ikarian Capital, LLC |
| 0.09% | 0.05% | #20 | $87.4万 | 13.2万股 | $63.4万 | 13.2万股 | 00.00% | 持仓不变 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | <0.01% | #48 | $82.4万 | 12.5万股 | $89.7万 | 18.7万股 | -6.2万股-33.36% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #52 | $70.4万 | 10.6万股 | $9.4万 | 2.0万股 | +8.7万股+440.83% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.01% | #29 | $53.7万 | 8.1万股 | $15.0万 | 3.1万股 | +5.0万股+159.86% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #92 | $53.4万 | 8.1万股 | $14.0万 | 2.9万股 | +5.2万股+177.14% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #73 | $51.7万 | 7.8万股 | $0 | 0股 | +7.8万股 | 新买入 |
| 阿尔茨舒勒·沙哈姆Altshuler Shaham Ltd |
| 0.01% | — | #39 | $47.6万 | 7.2万股 | $0 | 0股 | +7.2万股 | 新买入 |
| Independent Advisor Alliance |
| 0.01% | — | #34 | $46.2万 | 7.0万股 | $0 | 0股 | +7.0万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #63 | $40.8万 | 6.2万股 | $0 | 0股 | +6.2万股 | 新买入 |
| Blue Owl Capital Holdings LP |
| 0.06% | — | #24 | $39.6万 | 6.0万股 | $0 | 0股 | +6.0万股 | 新买入 |
| Persistent Asset Partners Ltd |
| 0.12% | — | #17 | $39.3万 | 5.1万股 | $0 | 0股 | +5.1万股 | 新买入 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #41 | $30.9万 | 4.7万股 | $0 | 0股 | +4.7万股 | 新买入 |
| PEAK6PEAK6 LLC |
| <0.01% | <0.01% | #54 | $28.7万 | 4.3万股 | $30.0万 | 6.3万股 | -1.9万股-30.64% | 减仓 |
| Fore Capital, LLC |
| 0.08% | 0.11% | #21 | $24.1万 | 3.6万股 | $17.5万 | 3.6万股 | 00.00% | 持仓不变 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #81 | $23.4万 | 3.6万股 | $15.1万 | 3.2万股 | +3,945股+12.49% | 加仓 |
| Mitsubishi UFJ Asset Management (UK) Ltd. |
| 0.1% | 0.04% | #19 | $20.5万 | 3.1万股 | $7.2万 | 1.5万股 | +1.6万股+106.67% | 加仓 |
| PDS Planning, Inc |
| 0.01% | 0.01% | #33 | $20.1万 | 3.0万股 | $14.5万 | 3.0万股 | 00.00% | 持仓不变 |
