| Siren, L.L.C. |
| 0.74% | 0.43% | #9 | $3,636.0万 | 331.1万股 | $1,534.3万 | 291.1万股 | +40.0万股+13.74% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.8% | 0.46% | #8 | $3,330.8万 | 303.4万股 | $1,598.7万 | 303.4万股 | 00.00% | 持仓不变 |
| Redmile Group, LLC |
| 1.6% | 0.76% | #4 | $2,376.9万 | 216.5万股 | $1,140.8万 | 216.5万股 | 00.00% | 持仓不变 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.49% | 0.42% | #11 | $1,478.7万 | 134.7万股 | $1,131.3万 | 214.7万股 | -80.0万股-37.27% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #37 | $1,459.9万 | 133.0万股 | $656.7万 | 124.6万股 | +8.4万股+6.70% | 加仓 |
| Tetragon Partners GP Ltd |
| 1.84% | 0.64% | #2 | $1,168.6万 | 106.4万股 | $332.1万 | 63.0万股 | +43.4万股+68.89% | 加仓 |
| Nextech Invest Ltd. |
| 0.5% | 0.35% | #10 | $1,045.7万 | 95.2万股 | $501.9万 | 95.2万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $998.4万 | 90.9万股 | $566.1万 | 107.4万股 | -16.5万股-15.35% | 减仓 |
| Ikarian Capital, LLC |
| 0.97% | 0.14% | #6 | $913.9万 | 83.1万股 | $173.2万 | 86.6万股 | -3.5万股-4.04% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.24% | — | #14 | $691.7万 | 63.0万股 | $0 | 0股 | +63.0万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #29 | $670.9万 | 61.1万股 | $0 | 0股 | +61.1万股 | 新买入 |
| 5AM Venture Management, LLC |
| 1.82% | 0.7% | #3 | $522.9万 | 47.6万股 | $251.0万 | 47.6万股 | 00.00% | 持仓不变 |
| Caption管理Caption Management, LLC |
| 0.02% | — | #23 | $505.5万 | 46.0万股 | $0 | 0股 | +46.0万股 | 新买入 |
| GREAT POINT PARTNERS LLC |
| 0.93% | 1.24% | #7 | $494.1万 | 45.0万股 | $537.8万 | 102.0万股 | -57.0万股-55.90% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #51 | $442.7万 | 40.3万股 | $626.8万 | 120.8万股 | -80.5万股-66.62% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #48 | $425.5万 | 38.8万股 | $53.2万 | 10.1万股 | +28.7万股+283.99% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #42 | $406.3万 | 37.0万股 | $0 | 0股 | +37.0万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 0.17% | 0.05% | #16 | $371.5万 | 33.8万股 | $90.7万 | 17.2万股 | +16.6万股+96.55% | 加仓 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.09% | — | #19 | $358.7万 | 32.7万股 | $0 | 0股 | +32.7万股 | 新买入 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.01% | — | #27 | $295.7万 | 26.9万股 | $0 | 0股 | +26.9万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #49 | $267.0万 | 24.3万股 | $130.1万 | 24.7万股 | -3,785股-1.53% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #53 | $256.6万 | 23.4万股 | $81.4万 | 15.4万股 | +7.9万股+51.39% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #62 | $241.5万 | 22.0万股 | $107.9万 | 20.5万股 | +1.5万股+7.39% | 加仓 |
| 蒙特利尔银行BANK OF MONTREAL /CAN/ |
| <0.01% | <0.01% | #43 | $221.5万 | 20.2万股 | $106.9万 | 20.3万股 | -1,167股-0.58% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.01% | #22 | $217.8万 | 19.8万股 | $110.2万 | 20.9万股 | -1.1万股-5.14% | 减仓 |
| Propel Bio Management, LLC |
| 1.1% | — | #5 | $210.5万 | 19.2万股 | $0 | 0股 | +19.2万股 | 新买入 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.01% | — | #30 | $194.3万 | 17.7万股 | $0 | 0股 | +17.7万股 | 新买入 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #36 | $180.0万 | 16.4万股 | $55.1万 | 10.5万股 | +5.9万股+56.80% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #41 | $174.5万 | 15.9万股 | $77.8万 | 14.8万股 | +1.1万股+7.64% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #55 | $171.2万 | 15.6万股 | $27.7万 | 5.3万股 | +10.3万股+196.95% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #40 | $132.9万 | 12.1万股 | $8.5万 | 1.6万股 | +10.5万股+646.80% | 加仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #46 | $132.4万 | 12.3万股 | $64.0万 | 12.3万股 | 00.00% | 持仓不变 |
| 正交资本Quadrature Capital Ltd |
| 0.01% | — | #26 | $129.7万 | 11.8万股 | $0 | 0股 | +11.8万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #39 | $127.3万 | 11.6万股 | $47.2万 | 8.9万股 | +2.6万股+29.56% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | 0.01% | #24 | $118.1万 | 10.8万股 | $55.9万 | 10.6万股 | +1,577股+1.49% | 加仓 |
| M28 Capital Management LP |
| 2.36% | 0.99% | #1 | $111.1万 | 10.1万股 | $53.3万 | 10.1万股 | 00.00% | 持仓不变 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #44 | $79.1万 | 7.2万股 | $89.4万 | 17.0万股 | -9.8万股-57.53% | 减仓 |
| Birchview Capital, LP |
| 0.35% | — | #13 | $78.2万 | 7.1万股 | $0 | 0股 | +7.1万股 | 新买入 |
| Seven Fleet Capital Management LP |
| 0.11% | 0.26% | #18 | $66.0万 | 6.0万股 | $82.6万 | 15.7万股 | -9.7万股-61.66% | 减仓 |
| Ishara Investments LP |
| 0.44% | 0.7% | #12 | $60.9万 | 5.5万股 | $74.0万 | 14.1万股 | -8.5万股-60.60% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | <0.01% | #45 | $33.8万 | 3.1万股 | $6.3万 | 1.2万股 | +1.9万股+156.36% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #65 | $32.4万 | 3.0万股 | $15.6万 | 3.0万股 | 00.00% | 持仓不变 |
| Virtu Financial LLC |
| 0.01% | — | #28 | $28.2万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #64 | $27.8万 | 2.5万股 | $15.7万 | 3.0万股 | -4,493股-15.09% | 减仓 |
| Trexquant投资Trexquant Investment LP |
| <0.01% | — | #38 | $26.2万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| Verdad Advisers, LP |
| 0.21% | — | #15 | $22.4万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| Scientech Research LLC |
| 0.17% | — | #17 | $21.0万 | 1.9万股 | $0 | 0股 | +1.9万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #50 | $18.6万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
| 0.04% | — | #21 | $17.9万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| Persistent Asset Partners Ltd |
| 0.05% | — | #20 | $16.7万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
