| BVF INC/IL |
| 8.25% | 2.59% | #1 | $3.23亿 | 759.3万股 | $8,125.8万 | 259.0万股 | +500.3万股+193.14% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #26 | $7,213.0万 | 169.7万股 | $6,347.5万 | 164.7万股 | +5.0万股+3.05% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #28 | $6,823.5万 | 160.6万股 | $4,087.4万 | 130.3万股 | +30.3万股+23.22% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.15% | 0.08% | #10 | $4,736.0万 | 111.4万股 | $2,007.7万 | 64.0万股 | +47.4万股+74.12% | 加仓 |
| Newtyn Management, LLC |
| 3.76% | — | #3 | $3,014.3万 | 70.9万股 | $0 | 0股 | +70.9万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $2,940.9万 | 69.2万股 | $2,029.4万 | 64.7万股 | +4.5万股+6.96% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $2,147.0万 | 50.5万股 | $1,724.7万 | 55.0万股 | -4.5万股-8.12% | 减仓 |
| Opaleye Management Inc. |
| 1.3% | 1.24% | #5 | $1,438.1万 | 33.8万股 | $941.1万 | 30.0万股 | +3.8万股+12.79% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $1,042.9万 | 24.5万股 | $721.0万 | 23.0万股 | +1.6万股+6.77% | 加仓 |
| WATER ISLAND CAPITAL LLC |
| 0.96% | — | #6 | $1,028.5万 | 24.2万股 | $0 | 0股 | +24.2万股 | 新买入 |
| ALPINE ASSOCIATES MANAGEMENT INC. |
| 0.64% | — | #7 | $1,017.1万 | 23.9万股 | $0 | 0股 | +23.9万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $962.7万 | 22.7万股 | $642.8万 | 20.5万股 | +2.2万股+10.53% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #53 | $840.5万 | 19.8万股 | $605.9万 | 19.3万股 | +4,616股+2.39% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #33 | $752.7万 | 17.7万股 | $418.2万 | 13.3万股 | +4.4万股+32.80% | 加仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | — | #29 | $631.4万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
| TORNO 资本TORNO CAPITAL, LLC |
| 0.17% | — | #9 | $593.7万 | 14.0万股 | $0 | 0股 | +14.0万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #47 | $569.6万 | 13.4万股 | $75.3万 | 2.4万股 | +11.0万股+458.66% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #45 | $408.8万 | 9.6万股 | $293.3万 | 9.3万股 | +2,689股+2.88% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $384.0万 | 9.0万股 | $269.1万 | 8.6万股 | +4,551股+5.30% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| <0.01% | — | #23 | $358.7万 | 8.4万股 | $0 | 0股 | +8.4万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #43 | $320.2万 | 7.5万股 | $235.2万 | 7.5万股 | +364股+0.49% | 加仓 |
| Verition基金管理Verition Fund Management LLC |
| <0.01% | — | #25 | $300.1万 | 7.1万股 | $0 | 0股 | +7.1万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #40 | $298.3万 | 7.0万股 | $209.1万 | 6.7万股 | +3,525股+5.29% | 加仓 |
| Simcoe Capital LLC |
| 1.76% | 1.96% | #4 | $289.2万 | 6.8万股 | $213.5万 | 6.8万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #57 | $244.3万 | 5.7万股 | $79.1万 | 2.5万股 | +3.2万股+127.97% | 加仓 |
| TLS Advisors LLC |
| 5.27% | 8.55% | #2 | $179.2万 | 4.2万股 | $360.3万 | 11.5万股 | -7.3万股-63.29% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #34 | $156.2万 | 3.7万股 | $81.8万 | 2.6万股 | +1.1万股+40.92% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | — | #19 | $148.9万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| CREDIT INDUSTRIEL ET COMMERCIAL |
| 0.09% | — | #14 | $148.1万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #31 | $147.1万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| RBF Capital, LLC |
| 0.05% | 0.05% | #16 | $127.5万 | 3.0万股 | $94.1万 | 3.0万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #71 | $126.5万 | 3.0万股 | $12.1万 | 3,992股 | +2.6万股+651.95% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #61 | $121.0万 | 2.8万股 | $345.8万 | 11.0万股 | -8.2万股-74.18% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #60 | $119.3万 | 2.8万股 | $85.2万 | 2.7万股 | +927股+3.41% | 加仓 |
| EQUITEC PROPRIETARY MARKETS, LLC |
| 0.21% | — | #8 | $119.0万 | 2.8万股 | $0 | 0股 | +2.8万股 | 新买入 |
| SIERRA SUMMIT ADVISORS LLC |
| 0.12% | — | #13 | $109.4万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #62 | $101.3万 | 2.4万股 | $227.5万 | 7.3万股 | -4.9万股-67.13% | 减仓 |
| CSS LLC/IL |
| 0.03% | — | #17 | $89.1万 | 2.1万股 | $0 | 0股 | +2.1万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #70 | $85.5万 | 2.0万股 | $75.3万 | 2.4万股 | -3,876股-16.15% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #58 | $78.1万 | 1.8万股 | $39.9万 | 1.3万股 | +5,682股+44.72% | 加仓 |
| MARTINGALE ASSET MANAGEMENT L P |
| 0.01% | — | #21 | $51.9万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #50 | $48.7万 | 1.1万股 | $36.7万 | 1.2万股 | -254股-2.17% | 减仓 |
| Yakira Capital Management, Inc. |
| 0.12% | — | #12 | $43.8万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| DIVERSIFIED MANAGEMENT INC |
| 0.09% | 0.05% | #15 | $42.5万 | 1.0万股 | $31.4万 | 1.0万股 | 00.00% | 持仓不变 |
| Regions金融REGIONS FINANCIAL CORP |
| <0.01% | <0.01% | #30 | $39.3万 | 9,250股 | $29.0万 | 9,250股 | 00.00% | 持仓不变 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #65 | $38.8万 | 9,139股 | $26.5万 | 8,447股 | +692股+8.19% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #75 | $36.1万 | 8,495股 | $12.1万 | 3,865股 | +4,630股+119.79% | 加仓 |
| Kintayl Capital LP |
| 0.14% | — | #11 | $36.0万 | 8,476股 | $0 | 0股 | +8,476股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #81 | $29.8万 | 7,005股 | $21.4万 | 6,803股 | +202股+2.97% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #83 | $29.2万 | 6,878股 | $34.6万 | 1.1万股 | -4,140股-37.57% | 减仓 |
