| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.51% | 0.67% | #5 | $1.74亿 | 1,795.6万股 | $6,345.5万 | 985.3万股 | +810.2万股+82.23% | 加仓 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.07% | — | #16 | $2,526.0万 | 260.4万股 | $0 | 0股 | +260.4万股 | 新买入 |
| 黑石集团Blackstone Inc. |
| 0.07% | — | #17 | $2,331.3万 | 240.3万股 | $0 | 0股 | +240.3万股 | 新买入 |
| 5AM Venture Management, LLC |
| 7.93% | 4.21% | #1 | $2,282.7万 | 235.3万股 | $1,515.5万 | 235.3万股 | 00.00% | 持仓不变 |
| Venrock Adviser, LLC |
| 0.6% | 0.39% | #10 | $1,982.3万 | 204.4万股 | $1,036.6万 | 161.0万股 | +43.4万股+26.97% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #29 | $1,937.3万 | 199.7万股 | $335.1万 | 52.0万股 | +147.7万股+283.84% | 加仓 |
| Caligan Partners LP |
| 0.79% | — | #8 | $1,684.0万 | 173.6万股 | $0 | 0股 | +173.6万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $952.4万 | 98.2万股 | $133.7万 | 20.8万股 | +77.4万股+372.74% | 加仓 |
| Samsara BioCapital, LLC |
| 0.76% | — | #9 | $926.2万 | 95.5万股 | $0 | 0股 | +95.5万股 | 新买入 |
| Blue Owl Capital Holdings LP |
| 1.24% | — | #7 | $848.3万 | 87.5万股 | $0 | 0股 | +87.5万股 | 新买入 |
| Propel Bio Management, LLC |
| 3.54% | 0.6% | #2 | $675.5万 | 69.6万股 | $95.0万 | 14.6万股 | +55.0万股+375.81% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #43 | $673.9万 | 69.5万股 | $137.4万 | 21.3万股 | +48.1万股+225.57% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #33 | $591.1万 | 60.9万股 | $10.2万 | 1.6万股 | +59.4万股+3,739.80% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.53% | — | #11 | $509.3万 | 52.5万股 | $0 | 0股 | +52.5万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $343.4万 | 35.4万股 | $65.5万 | 10.2万股 | +25.2万股+247.95% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.04% | — | #20 | $304.9万 | 31.4万股 | $0 | 0股 | +31.4万股 | 新买入 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.1% | — | #15 | $291.0万 | 30.0万股 | $0 | 0股 | +30.0万股 | 新买入 |
| Revelation Capital Management, LLC |
| 2.65% | 2.86% | #3 | $290.3万 | 29.9万股 | $192.8万 | 29.9万股 | 00.00% | 持仓不变 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.01% | <0.01% | #24 | $265.4万 | 27.4万股 | $64.4万 | 10.0万股 | +17.4万股+173.62% | 加仓 |
| ACUTA CAPITAL PARTNERS, LLC |
| 1.76% | — | #4 | $252.6万 | 26.0万股 | $0 | 0股 | +26.0万股 | 新买入 |
| KVP Capital Advisors, LP |
| 1.42% | — | #6 | $194.0万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #35 | $188.3万 | 19.4万股 | $125.0万 | 19.4万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #38 | $178.5万 | 18.4万股 | $9,834 | 1,527股 | +18.2万股+11,951.08% | 加仓 |
| SEVEN GRAND MANAGERS, LLC |
| 0.07% | — | #18 | $169.8万 | 17.5万股 | $0 | 0股 | +17.5万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #51 | $160.8万 | 16.6万股 | $23.1万 | 3.6万股 | +13.0万股+362.72% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #31 | $146.5万 | 15.1万股 | $51.5万 | 8.0万股 | +7.1万股+88.66% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $143.9万 | 14.8万股 | $21.1万 | 3.3万股 | +11.6万股+352.28% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.05% | — | #19 | $115.1万 | 11.9万股 | $0 | 0股 | +11.9万股 | 新买入 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.01% | <0.01% | #23 | $98.3万 | 10.1万股 | $15.0万 | 2.3万股 | +7.8万股+336.31% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #22 | $82.5万 | 8.5万股 | $22.5万 | 3.5万股 | +5.0万股+142.86% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #34 | $76.2万 | 7.9万股 | $74.1万 | 11.5万股 | -3.6万股-31.70% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #44 | $74.1万 | 7.6万股 | $7.9万 | 1.2万股 | +6.4万股+526.01% | 加仓 |
| DAFNA Capital Management LLC |
| 0.12% | — | #14 | $65.1万 | 6.7万股 | $0 | 0股 | +6.7万股 | 新买入 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #27 | $47.9万 | 4.9万股 | $0 | 0股 | +4.9万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #45 | $43.5万 | 4.5万股 | $13.1万 | 2.0万股 | +2.4万股+120.00% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | <0.01% | #25 | $41.2万 | 4.3万股 | $13.1万 | 2.0万股 | +2.2万股+109.71% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #59 | $30.2万 | 3.1万股 | $0 | 0股 | +3.1万股 | 新买入 |
| Velan Capital Investment Management LP |
| 0.15% | 0.1% | #13 | $24.3万 | 2.5万股 | $16.1万 | 2.5万股 | 00.00% | 持仓不变 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #37 | $22.3万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| Atom Investors LP |
| 0.02% | — | #21 | $22.2万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| 贝拉德公司BAILARD, INC. |
| <0.01% | <0.01% | #28 | $20.1万 | 2.1万股 | $13.3万 | 2.1万股 | 00.00% | 持仓不变 |
| Spark Investment Management LLC |
| 0.31% | — | #12 | $16.0万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #60 | $15.3万 | 1.6万股 | $7.4万 | 1.1万股 | +4,315股+37.64% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #41 | $14.4万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | — | #52 | $13.6万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | — | #50 | $11.6万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #58 | $11.5万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #47 | $5.9万 | 6,100股 | $0 | 0股 | +6,100股 | 新买入 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #53 | $5.7万 | 5,861股 | $3.5万 | 5,491股 | +370股+6.74% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #62 | $5.3万 | 5,480股 | $9,660 | 1,500股 | +3,980股+265.33% | 加仓 |
