| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.19% | 0.37% | #9 | $3,733.5万 | 507.3万股 | $6,401.8万 | 507.3万股 | 00.00% | 持仓不变 |
| 5AM Venture Management, LLC |
| 10.37% | 14.21% | #1 | $2,985.5万 | 405.6万股 | $5,119.2万 | 405.6万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #64 | $1,901.3万 | 258.3万股 | $2,976.8万 | 235.9万股 | +22.5万股+9.52% | 加仓 |
| Merck & Co., Inc. |
| 2.43% | 6.28% | #2 | $1,280.5万 | 174.0万股 | $2,195.6万 | 174.0万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #73 | $934.5万 | 127.0万股 | $1,585.1万 | 125.6万股 | +1.4万股+1.08% | 加仓 |
| MPM BioImpact LLC |
| 0.56% | — | #4 | $922.2万 | 125.3万股 | $0 | 0股 | +125.3万股 | 新买入 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.19% | 0.83% | #8 | $780.3万 | 106.0万股 | $2,886.8万 | 228.8万股 | -122.7万股-53.65% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #43 | $702.5万 | 95.4万股 | $1,305.9万 | 103.5万股 | -8.0万股-7.77% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #38 | $562.3万 | 76.4万股 | $655.4万 | 51.9万股 | +24.5万股+47.10% | 加仓 |
| StepStone Group LP |
| 2.33% | 4.63% | #3 | $532.9万 | 76.1万股 | $960.7万 | 76.1万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #63 | $528.1万 | 71.7万股 | $842.4万 | 66.7万股 | +5.0万股+7.50% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $514.9万 | 70.0万股 | $100.3万 | 7.9万股 | +62.0万股+780.00% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #81 | $439.2万 | 59.7万股 | $673.7万 | 53.4万股 | +6.3万股+11.78% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #57 | $399.1万 | 54.2万股 | $663.9万 | 52.6万股 | +1.6万股+3.09% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #71 | $382.8万 | 49.6万股 | $17.5万 | 1.5万股 | +48.2万股+3,243.82% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #29 | $295.0万 | 40.1万股 | $420.1万 | 33.3万股 | +6.8万股+20.32% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #62 | $290.2万 | 39.4万股 | $271.4万 | 21.5万股 | +17.9万股+83.39% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #53 | $277.0万 | 37.6万股 | $409.2万 | 32.4万股 | +5.2万股+15.92% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #66 | $228.1万 | 31.0万股 | $296.6万 | 23.5万股 | +7.5万股+31.89% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | 0.02% | #19 | $223.3万 | 30.3万股 | $421.4万 | 33.4万股 | -3.0万股-9.12% | 减仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.07% | 0.07% | #10 | $221.2万 | 30.1万股 | $201.1万 | 15.9万股 | +14.1万股+88.65% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $187.0万 | 25.4万股 | $278.3万 | 22.0万股 | +3.4万股+15.25% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #74 | $145.1万 | 19.7万股 | $271.0万 | 21.5万股 | -1.8万股-8.20% | 减仓 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.03% | 0.1% | #13 | $143.7万 | 19.5万股 | $258.7万 | 20.5万股 | -9,741股-4.75% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #95 | $141.1万 | 19.2万股 | $201.1万 | 34.7万股 | -15.5万股-44.73% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #37 | $140.6万 | 19.1万股 | $255.0万 | 20.2万股 | -1.1万股-5.48% | 减仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| <0.01% | <0.01% | #40 | $139.0万 | 18.9万股 | $89.6万 | 7.1万股 | +11.8万股+165.90% | 加仓 |
| Lynx1 Capital Management LP |
| 0.26% | 0.42% | #6 | $131.5万 | 17.9万股 | $267.2万 | 21.2万股 | -3.3万股-15.63% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #86 | $130.5万 | 17.7万股 | $268.5万 | 21.3万股 | -3.5万股-16.65% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #65 | $123.4万 | 16.8万股 | $198.0万 | 15.7万股 | +1.1万股+6.88% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| <0.01% | 0.01% | #31 | $107.2万 | 14.6万股 | $272.6万 | 21.6万股 | -7.0万股-32.59% | 减仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | 0.01% | #22 | $103.1万 | 14.0万股 | $104.4万 | 8.3万股 | +5.7万股+69.39% | 加仓 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.01% | 0.03% | #17 | $77.3万 | 10.5万股 | $132.5万 | 10.5万股 | 00.00% | 持仓不变 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.03% | #18 | $70.2万 | 9.5万股 | $163.5万 | 13.0万股 | -3.4万股-26.42% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #61 | $70.0万 | 9.5万股 | $228.6万 | 18.1万股 | -8.6万股-47.53% | 减仓 |
| Allspring环球投资Allspring Global Investments Holdings, LLC |
| <0.01% | <0.01% | #44 | $68.8万 | 9.4万股 | $24.6万 | 1.9万股 | +7.4万股+380.54% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | — | #11 | $64.8万 | 8.8万股 | $0 | 0股 | +8.8万股 | 新买入 |
| Royce联营ROYCE & ASSOCIATES LP |
| <0.01% | 0.02% | #25 | $61.0万 | 8.3万股 | $152.5万 | 12.1万股 | -3.8万股-31.40% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #67 | $58.7万 | 8.0万股 | $98.4万 | 7.8万股 | +1,730股+2.22% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #89 | $58.2万 | 7.9万股 | $96.5万 | 7.6万股 | +2,643股+3.46% | 加仓 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #56 | $53.4万 | 7.3万股 | $89.2万 | 7.1万股 | +1,864股+2.64% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #87 | $51.8万 | 7.0万股 | $88.7万 | 7.0万股 | +115股+0.16% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #55 | $44.8万 | 6.1万股 | $110.4万 | 8.7万股 | -2.7万股-30.39% | 减仓 |
| 康托·菲茨杰拉德CANTOR FITZGERALD, L. P. |
| <0.01% | 0.01% | #26 | $44.2万 | 6.0万股 | $59.3万 | 4.7万股 | +1.3万股+27.66% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #111 | $42.6万 | 5.8万股 | $49.5万 | 3.9万股 | +1.9万股+47.73% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #88 | $41.8万 | 5.7万股 | $221.7万 | 17.6万股 | -11.9万股-67.68% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #21 | $39.8万 | 5.4万股 | $0 | 0股 | +5.4万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #60 | $39.4万 | 5.4万股 | $67.6万 | 5.4万股 | 00.00% | 持仓不变 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| <0.01% | — | #34 | $38.8万 | 5.3万股 | $0 | 0股 | +5.3万股 | 新买入 |
| Nan Fung Group Holdings Ltd |
| 0.27% | 0.51% | #5 | $36.1万 | 4.9万股 | $61.9万 | 4.9万股 | 00.00% | 持仓不变 |
