| BVF INC/IL |
| 5.95% | 3.87% | #1 | $2.33亿 | 865.0万股 | $1.22亿 | 865.0万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.78% | 1.14% | #3 | $2.05亿 | 763.7万股 | $1.08亿 | 767.7万股 | -4.0万股-0.52% | 减仓 |
| 富达投资FMR LLC |
| 0.01% | <0.01% | #20 | $1.61亿 | 597.7万股 | $7,221.3万 | 513.6万股 | +84.1万股+16.37% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 1.36% | 0.83% | #4 | $1.60亿 | 593.4万股 | $8,342.9万 | 593.4万股 | 00.00% | 持仓不变 |
| 深轨资本Deep Track Capital, LP |
| 1.3% | — | #6 | $8,960.0万 | 333.3万股 | $0 | 0股 | +333.3万股 | 新买入 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 0.43% | 0.25% | #8 | $4,838.4万 | 180.0万股 | $2,530.8万 | 180.0万股 | 00.00% | 持仓不变 |
| Foresite Capital Management VI LLC |
| 3.93% | 0.96% | #2 | $2,528.0万 | 94.0万股 | $443.6万 | 31.5万股 | +62.5万股+198.10% | 加仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.13% | 0.07% | #11 | $1,914.7万 | 71.2万股 | $1,001.5万 | 71.2万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #44 | $1,291.0万 | 48.0万股 | $640.6万 | 45.6万股 | +2.5万股+5.41% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #26 | $1,283.3万 | 47.7万股 | $579.9万 | 41.2万股 | +6.5万股+15.76% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #25 | $869.3万 | 32.3万股 | $1,318.7万 | 93.8万股 | -61.4万股-65.52% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | — | #33 | $571.6万 | 21.3万股 | $0 | 0股 | +21.3万股 | 新买入 |
| BRAIDWELL LP |
| 0.21% | — | #10 | $557.1万 | 20.7万股 | $0 | 0股 | +20.7万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.07% | 0.05% | #14 | $543.3万 | 20.2万股 | $397.7万 | 28.3万股 | -8.1万股-28.56% | 减仓 |
| HighVista Strategies LLC |
| 0.97% | 0.83% | #7 | $426.8万 | 15.9万股 | $299.8万 | 21.3万股 | -5.4万股-25.53% | 减仓 |
| Trexquant投资Trexquant Investment LP |
| 0.02% | 0.01% | #17 | $413.3万 | 15.4万股 | $98.2万 | 7.0万股 | +8.4万股+120.27% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #36 | $399.6万 | 14.9万股 | $63.0万 | 4.5万股 | +10.4万股+231.90% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #39 | $284.3万 | 10.6万股 | $92.0万 | 6.5万股 | +4.0万股+61.54% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.03% | 0.01% | #16 | $233.8万 | 8.7万股 | $73.2万 | 5.2万股 | +3.5万股+66.99% | 加仓 |
| AdvisorShares Investments LLC |
| 0.23% | 0.17% | #9 | $191.6万 | 7.1万股 | $94.2万 | 6.7万股 | +4,233股+6.31% | 加仓 |
| CenterBook Partners LP |
| 0.09% | 0.16% | #13 | $186.6万 | 6.9万股 | $304.5万 | 21.7万股 | -14.7万股-67.94% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #24 | $175.7万 | 6.5万股 | $0 | 0股 | +6.5万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #51 | $140.4万 | 5.2万股 | $6.1万 | 4,242股 | +4.8万股+1,130.98% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #27 | $136.8万 | 5.1万股 | $0 | 0股 | +5.1万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #30 | $125.5万 | 4.7万股 | $128.1万 | 9.1万股 | -4.4万股-48.75% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | — | #29 | $118.1万 | 4.4万股 | $0 | 0股 | +4.4万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #53 | $108.8万 | 4.0万股 | $56.9万 | 4.0万股 | 00.00% | 持仓不变 |
| Axxion S.A. |
| 0.07% | — | #15 | $97.2万 | 3.6万股 | $0 | 0股 | +3.6万股 | 新买入 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #28 | $92.1万 | 3.4万股 | $26.1万 | 1.9万股 | +1.6万股+84.69% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #48 | $85.6万 | 3.2万股 | $46.0万 | 3.3万股 | -841股-2.57% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #40 | $68.1万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #22 | $56.8万 | 2.1万股 | $0 | 0股 | +2.1万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #55 | $53.5万 | 1.9万股 | $24.6万 | 1.9万股 | -75股-0.40% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #32 | $49.5万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| Virtus Investment Advisers, LLC |
| 0.1% | 0.08% | #12 | $41.6万 | 1.5万股 | $29.4万 | 2.1万股 | -5,428股-25.95% | 减仓 |
| 莱特科·布罗索联合LETKO, BROSSEAU & ASSOCIATES INC |
| 0.01% | — | #21 | $41.5万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| China Universal Asset Management Co., Ltd. |
| 0.02% | 0.01% | #18 | $36.1万 | 1.3万股 | $19.0万 | 1.4万股 | -88股-0.65% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #56 | $36.0万 | 1.3万股 | $15.7万 | 1.1万股 | +2,200股+19.64% | 加仓 |
| HighTower顾问HighTower Advisors, LLC |
| <0.01% | <0.01% | #38 | $34.1万 | 1.3万股 | $21.9万 | 1.6万股 | -2,900股-18.59% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #62 | $30.0万 | 1.1万股 | $15.5万 | 1.1万股 | +114股+1.03% | 加仓 |
| Lion Point Capital, LP |
| 1.31% | 0.86% | #5 | $27.4万 | 1.0万股 | $14.3万 | 1.0万股 | 00.00% | 持仓不变 |
| Eversept Partners, LP |
| 0.01% | — | #19 | $23.3万 | 8,672股 | $0 | 0股 | +8,672股 | 新买入 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | — | #49 | $21.6万 | 7,847股 | $0 | 0股 | +7,847股 | 新买入 |
| 美世全球顾问MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #43 | $17.2万 | 6,394股 | $0 | 0股 | +6,394股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #54 | $16.1万 | 5,977股 | $6.2万 | 4,394股 | +1,583股+36.03% | 加仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #57 | $15.8万 | 5,877股 | $3.6万 | 2,567股 | +3,310股+128.94% | 加仓 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #45 | $15.5万 | 5,775股 | $8.3万 | 5,925股 | -150股-2.53% | 减仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #50 | $12.7万 | 4,739股 | $1,166 | 83股 | +4,656股+5,609.64% | 加仓 |
| 未来资产环球投资Mirae Asset Global Investments Co., Ltd. |
| <0.01% | <0.01% | #47 | $8.2万 | 3,068股 | $4.5万 | 3,235股 | -167股-5.16% | 减仓 |
| North Star Investment Management Corp. |
| <0.01% | <0.01% | #23 | $5.9万 | 2,200股 | $3.1万 | 2,200股 | 00.00% | 持仓不变 |
