| Redmile Group, LLC |
| 2.33% | 1.02% | #1 | $3,475.7万 | 1,287.3万股 | $1,544.8万 | 1,287.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #79 | $1,970.7万 | 729.9万股 | $1,208.2万 | 1,006.9万股 | -277.0万股-27.51% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $1,227.4万 | 454.6万股 | $496.2万 | 413.5万股 | +41.1万股+9.95% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $1,200.3万 | 444.6万股 | $503.0万 | 419.2万股 | +25.3万股+6.05% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #17 | $1,174.8万 | 435.1万股 | $493.8万 | 412.0万股 | +23.1万股+5.61% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #29 | $1,036.1万 | 383.7万股 | $360.2万 | 300.2万股 | +83.6万股+27.84% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #23 | $969.3万 | 359.0万股 | $416.0万 | 346.7万股 | +12.3万股+3.55% | 加仓 |
| JOHNSON & JOHNSON |
| 1.14% | 0.62% | #2 | $912.3万 | 337.9万股 | $405.5万 | 337.9万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #20 | $805.5万 | 298.3万股 | $357.0万 | 297.5万股 | +8,585股+0.29% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #36 | $657.2万 | 243.4万股 | $0 | 0股 | +243.4万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #65 | $553.3万 | 204.9万股 | $159.3万 | 132.8万股 | +72.1万股+54.33% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #90 | $357.1万 | 132.2万股 | $310.9万 | 259.0万股 | -126.8万股-48.97% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #83 | $302.8万 | 112.1万股 | $79.4万 | 66.2万股 | +46.0万股+69.50% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #76 | $295.3万 | 109.4万股 | $116.4万 | 97.0万股 | +12.3万股+12.72% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| <0.01% | — | #38 | $291.7万 | 108.0万股 | $0 | 0股 | +108.0万股 | 新买入 |
| Bruce & Co., Inc. |
| 0.75% | 0.27% | #3 | $267.1万 | 98.9万股 | $94.7万 | 78.9万股 | +20.0万股+25.34% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #110 | $187.5万 | 69.5万股 | $117.2万 | 93.0万股 | -23.5万股-25.31% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #102 | $181.5万 | 67.2万股 | $45.7万 | 38.0万股 | +29.2万股+76.62% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #74 | $172.9万 | 64.0万股 | $78.5万 | 65.4万股 | -1.3万股-2.04% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #86 | $165.0万 | 61.1万股 | $90.8万 | 75.6万股 | -14.5万股-19.22% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #88 | $159.3万 | 59.0万股 | $218.6万 | 182.2万股 | -123.2万股-67.60% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | — | #43 | $156.1万 | 57.8万股 | $0 | 0股 | +57.8万股 | 新买入 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #31 | $155.2万 | 57.5万股 | $56.4万 | 47.0万股 | +10.5万股+22.40% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #125 | $150.9万 | 55.9万股 | $271.6万 | 226.3万股 | -170.4万股-75.30% | 减仓 |
| DAFNA Capital Management LLC |
| 0.27% | 0.15% | #4 | $141.8万 | 52.5万股 | $66.0万 | 55.0万股 | -2.5万股-4.55% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #49 | $133.0万 | 49.2万股 | $0 | 0股 | +49.2万股 | 新买入 |
| IEQ资本IEQ CAPITAL, LLC |
| 0.01% | <0.01% | #26 | $131.7万 | 48.8万股 | $39.0万 | 32.5万股 | +16.3万股+50.17% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #45 | $119.4万 | 44.2万股 | $5.2万 | 4.3万股 | +39.9万股+925.60% | 加仓 |
| Privium Fund Management B.V. |
| 0.21% | 0.1% | #5 | $111.9万 | 41.4万股 | $49.7万 | 41.4万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #93 | $94.9万 | 35.2万股 | $106.0万 | 88.4万股 | -53.2万股-60.15% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #15 | $91.3万 | 33.8万股 | $0 | 0股 | +33.8万股 | 新买入 |
| Cerity合伙人Cerity Partners LLC |
| <0.01% | <0.01% | #50 | $85.4万 | 34.2万股 | $13.6万 | 11.4万股 | +22.8万股+200.97% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #75 | $73.3万 | 27.2万股 | $3.1万 | 2.6万股 | +24.6万股+956.33% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #122 | $71.8万 | 26.6万股 | $45.1万 | 37.6万股 | -11.0万股-29.24% | 减仓 |
| Headlands Technologies LLC |
| 0.07% | 0.02% | #7 | $68.0万 | 25.2万股 | $15.1万 | 12.6万股 | +12.6万股+100.31% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #107 | $66.4万 | 24.6万股 | $0 | 0股 | +24.6万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #117 | $65.5万 | 24.3万股 | $97.4万 | 81.2万股 | -56.9万股-70.11% | 减仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #81 | $63.6万 | 24.1万股 | $11.6万 | 9.8万股 | +14.3万股+146.43% | 加仓 |
| LPL金融LPL Financial LLC |
| <0.01% | <0.01% | #105 | $55.0万 | 20.4万股 | $19.5万 | 16.3万股 | +4.1万股+25.19% | 加仓 |
| MarinerMariner, LLC |
| <0.01% | <0.01% | #63 | $51.9万 | 19.2万股 | $11.8万 | 9.8万股 | +9.4万股+95.55% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #112 | $50.8万 | 18.8万股 | $8.8万 | 7.3万股 | +11.5万股+157.53% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #22 | $50.0万 | 18.5万股 | $22.2万 | 18.5万股 | 00.00% | 持仓不变 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #24 | $48.8万 | 18.1万股 | $46.7万 | 38.9万股 | -20.8万股-53.54% | 减仓 |
| 英仕曼集团Man Group plc |
| <0.01% | <0.01% | #55 | $47.5万 | 17.6万股 | $51.6万 | 43.0万股 | -25.4万股-59.05% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| <0.01% | <0.01% | #44 | $43.1万 | 16.0万股 | $28.6万 | 23.9万股 | -7.9万股-33.10% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #132 | $41.5万 | 15.4万股 | $22.6万 | 18.9万股 | -3.5万股-18.49% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #66 | $41.5万 | 15.4万股 | $0 | 0股 | +15.4万股 | 新买入 |
| Arete Wealth 顾问Arete Wealth Advisors, LLC |
| 0.01% | — | #18 | $40.5万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #64 | $39.4万 | 14.6万股 | $22.8万 | 19.0万股 | -4.4万股-23.34% | 减仓 |
| 美国国家慈善信托National Philanthropic Trust |
| <0.01% | 0.01% | #28 | $33.8万 | 12.5万股 | $46.8万 | 12.5万股 | 00.00% | 持仓不变 |
