| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #52 | $1,570.5万 | 363.5万股 | $1,153.7万 | 327.8万股 | +35.8万股+10.92% | 加仓 |
| Blue Water Life Science Advisors, LP |
| 9.45% | 6.05% | #1 | $1,500.9万 | 347.4万股 | $754.0万 | 214.2万股 | +133.2万股+62.18% | 加仓 |
| 第一鹰投资管理First Eagle Investment Management, LLC |
| 0.02% | 0.01% | #12 | $1,189.4万 | 275.3万股 | $457.6万 | 130.0万股 | +145.3万股+111.77% | 加仓 |
| Portolan 资本管理Portolan Capital Management, LLC |
| 0.31% | 0.55% | #5 | $820.5万 | 189.9万股 | $1,036.9万 | 294.6万股 | -104.7万股-35.53% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #64 | $777.9万 | 180.1万股 | $628.2万 | 178.5万股 | +1.6万股+0.90% | 加仓 |
| Lionhunter Capital Management, LLC |
| 2.92% | — | #2 | $648.2万 | 150.0万股 | $0 | 0股 | +150.0万股 | 新买入 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $580.2万 | 134.3万股 | $29.6万 | 8.4万股 | +125.9万股+1,496.31% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #49 | $488.9万 | 113.1万股 | $350.3万 | 99.5万股 | +13.7万股+13.73% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #33 | $426.6万 | 98.7万股 | $1,246.9万 | 354.2万股 | -255.5万股-72.13% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #20 | $420.7万 | 97.4万股 | $219.1万 | 62.2万股 | +35.1万股+56.48% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #72 | $402.8万 | 93.2万股 | $316.2万 | 89.8万股 | +3.4万股+3.79% | 加仓 |
| Tikvah Management LLC |
| 0.75% | 0.62% | #4 | $246.9万 | 57.2万股 | $201.2万 | 57.2万股 | -64股-0.01% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #79 | $211.5万 | 49.0万股 | $203.0万 | 57.7万股 | -8.7万股-15.09% | 减仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | — | #16 | $210.6万 | 48.8万股 | $0 | 0股 | +48.8万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #75 | $193.4万 | 44.8万股 | $437.8万 | 80.6万股 | -35.9万股-44.47% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #66 | $187.2万 | 43.3万股 | $54.8万 | 15.6万股 | +27.8万股+178.40% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.11% | 0.02% | #7 | $177.2万 | 41.0万股 | $33.6万 | 9.6万股 | +31.5万股+329.46% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #25 | $173.0万 | 40.0万股 | $111.2万 | 31.6万股 | +8.4万股+26.71% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #46 | $171.9万 | 39.8万股 | $155.9万 | 44.3万股 | -4.5万股-10.22% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #62 | $145.7万 | 33.7万股 | $123.1万 | 35.0万股 | -1.2万股-3.56% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #59 | $134.2万 | 31.1万股 | $121.8万 | 34.6万股 | -3.5万股-10.18% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #48 | $124.6万 | 28.8万股 | $95.2万 | 27.1万股 | +1.8万股+6.57% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #67 | $121.8万 | 28.2万股 | $132.7万 | 37.7万股 | -9.5万股-25.20% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #27 | $112.3万 | 26.0万股 | $0 | 0股 | +26.0万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #50 | $100.5万 | 23.3万股 | $25.3万 | 7.2万股 | +16.1万股+223.75% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #73 | $99.2万 | 23.0万股 | $30.8万 | 8.8万股 | +14.2万股+162.25% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #13 | $98.5万 | 22.8万股 | $39.3万 | 11.2万股 | +11.6万股+104.22% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #31 | $97.5万 | 22.6万股 | $32.8万 | 9.3万股 | +13.2万股+141.98% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #83 | $91.6万 | 21.2万股 | $95.1万 | 27.0万股 | -5.8万股-21.52% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #100 | $91.0万 | 21.1万股 | $64.5万 | 18.3万股 | +2.7万股+14.88% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #88 | $82.3万 | 19.0万股 | $23.2万 | 6.6万股 | +12.4万股+188.43% | 加仓 |
| IRONWOOD INVESTMENT MANAGEMENT LLC |
| 0.25% | 0.25% | #6 | $73.7万 | 17.1万股 | $59.8万 | 17.0万股 | +730股+0.43% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #92 | $69.5万 | 16.1万股 | $40.9万 | 11.6万股 | +4.5万股+38.44% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #74 | $64.4万 | 14.9万股 | $45.4万 | 12.9万股 | +2.0万股+15.60% | 加仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #15 | $64.2万 | 14.9万股 | $0 | 0股 | +14.9万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #47 | $59.1万 | 13.7万股 | $47.3万 | 13.4万股 | +2,473股+1.84% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #81 | $57.0万 | 13.2万股 | $44.5万 | 12.6万股 | +5,537股+4.38% | 加仓 |
| SCS资本管理SCS Capital Management LLC |
| <0.01% | <0.01% | #19 | $51.9万 | 12.0万股 | $42.3万 | 12.0万股 | 00.00% | 持仓不变 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #57 | $43.4万 | 10.0万股 | $35.8万 | 10.2万股 | -1,347股-1.32% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #99 | $41.3万 | 9.6万股 | $24.1万 | 6.8万股 | +2.7万股+39.86% | 加仓 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #22 | $34.6万 | 8.0万股 | $0 | 0股 | +8.0万股 | 新买入 |
| Cerity合伙人Cerity Partners LLC |
| <0.01% | — | #42 | $33.7万 | 7.8万股 | $0 | 0股 | +7.8万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #18 | $29.5万 | 6.8万股 | $24.0万 | 6.8万股 | 00.00% | 持仓不变 |
| Clearstead顾问Clearstead Advisors, LLC |
| <0.01% | <0.01% | #24 | $26.9万 | 6.2万股 | $43.7万 | 12.4万股 | -6.2万股-49.84% | 减仓 |
| Jain GlobalJain Global LLC |
| <0.01% | — | #32 | $24.8万 | 5.7万股 | $0 | 0股 | +5.7万股 | 新买入 |
| Algert全球ALGERT GLOBAL LLC |
| <0.01% | — | #23 | $23.9万 | 5.5万股 | $0 | 0股 | +5.5万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #60 | $23.1万 | 5.4万股 | $18.3万 | 5.2万股 | +1,492股+2.87% | 加仓 |
| PEDDOCK CAPITAL ADVISORS, LLC |
| 0.04% | 0.04% | #8 | $22.5万 | 5.2万股 | $18.3万 | 5.2万股 | 00.00% | 持仓不变 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #86 | $20.0万 | 5.7万股 | $28.3万 | 4.4万股 | +1.2万股+27.65% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #90 | $17.6万 | 4.1万股 | $242.6万 | 68.9万股 | -64.9万股-94.10% | 减仓 |
