| 富达投资FMR LLC |
| 0.16% | 0.12% | #88 | $36.32亿 | 5,186.0万股 | $23.20亿 | 4,567.2万股 | +618.8万股+13.55% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.03% | 0.03% | #211 | $21.43亿 | 3,059.9万股 | $15.06亿 | 2,963.6万股 | +96.4万股+3.25% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.03% | 0.03% | #193 | $16.25亿 | 2,320.9万股 | $11.62亿 | 2,287.2万股 | +33.6万股+1.47% | 加仓 |
| 资本世界投资者Capital World Investors |
| 0.18% | 0.13% | #79 | $15.60亿 | 2,227.7万股 | $9.50亿 | 1,869.8万股 | +357.9万股+19.14% | 加仓 |
| 百利吉福德BAILLIE GIFFORD & CO |
| 1.16% | 0.99% | #21 | $12.75亿 | 1,820.7万股 | $10.15亿 | 1,998.6万股 | -177.9万股-8.90% | 减仓 |
| 道富集团STATE STREET CORP |
| 0.03% | 0.03% | #202 | $11.01亿 | 1,572.6万股 | $7.55亿 | 1,486.1万股 | +86.5万股+5.82% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.05% | 0.04% | #159 | $10.91亿 | 1,558.1万股 | $7.93亿 | 1,561.6万股 | -3.5万股-0.22% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.06% | 0.07% | #152 | $7.34亿 | 1,048.7万股 | $6.39亿 | 1,257.6万股 | -208.8万股-16.61% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.04% | 0.03% | #188 | $6.79亿 | 971.0万股 | $4.78亿 | 943.5万股 | +27.5万股+2.92% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.04% | 0.02% | #190 | $6.68亿 | 953.8万股 | $2.57亿 | 996.2万股 | -42.4万股-4.26% | 减仓 |
| Theleme Partners LLP |
| 33.52% | 27.24% | #1 | $5.64亿 | 805.8万股 | $4.09亿 | 804.8万股 | +9,326股+0.12% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| 0.04% | 0.05% | #170 | $5.09亿 | 726.5万股 | $3.74亿 | 735.4万股 | -8.9万股-1.20% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.37% | 0.38% | #51 | $5.07亿 | 724.2万股 | $4.68亿 | 920.7万股 | -196.5万股-21.34% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.05% | 0.06% | #157 | $4.36亿 | 623.2万股 | $3.59亿 | 706.5万股 | -83.3万股-11.79% | 减仓 |
| 景顺Invesco Ltd. |
| 0.03% | 0.04% | #209 | $4.05亿 | 578.0万股 | $2.43亿 | 478.5万股 | +99.6万股+20.81% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.04% | <0.01% | #180 | $3.91亿 | 559.0万股 | $3,752.1万 | 73.9万股 | +485.1万股+656.80% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.05% | 0.06% | #163 | $3.62亿 | 516.8万股 | $4.24亿 | 833.7万股 | -316.9万股-38.01% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.05% | 0.04% | #165 | $3.39亿 | 483.9万股 | $2.41亿 | 473.4万股 | +10.5万股+2.21% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.03% | 0.04% | #222 | $3.36亿 | 479.7万股 | $3.44亿 | 677.1万股 | -197.4万股-29.15% | 减仓 |
| Flagship Pioneering, LLC |
| 21.07% | 20.26% | #3 | $3.24亿 | 463.2万股 | $2.35亿 | 463.2万股 | 00.00% | 持仓不变 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.15% | 0.12% | #91 | $3.22亿 | 437.9万股 | $2.49亿 | 432.3万股 | +5.6万股+1.30% | 加仓 |
| Tidal投资Tidal Investments LLC |
| 0.48% | 0.54% | #43 | $2.75亿 | 393.3万股 | $2.58亿 | 507.9万股 | -114.6万股-22.56% | 减仓 |
| 挪威央行投资管理NORGES BANK |
| 0.02% | 0.01% | #264 | $2.12亿 | 302.6万股 | $7,763.8万 | 273.9万股 | +28.8万股+10.50% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.02% | 0.02% | #245 | $2.09亿 | 298.5万股 | $1.50亿 | 295.2万股 | +3.3万股+1.13% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.1% | 0.16% | #114 | $2.01亿 | 286.6万股 | $2.72亿 | 535.1万股 | -248.6万股-46.45% | 减仓 |
| 百达银行BANQUE PICTET & CIE SA |
| 1.18% | 0.98% | #19 | $1.89亿 | 269.9万股 | $1.40亿 | 274.9万股 | -4.9万股-1.80% | 减仓 |
| 花旗集团CITIGROUP INC |
| 0.06% | 0.14% | #149 | $1.75亿 | 250.0万股 | $3.20亿 | 630.0万股 | -379.9万股-60.31% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.03% | 0.02% | #213 | $1.73亿 | 246.9万股 | $1.08亿 | 213.2万股 | +33.7万股+15.79% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.02% | #220 | $1.72亿 | 246.2万股 | $1.20亿 | 235.8万股 | +10.4万股+4.41% | 加仓 |
| LMR合伙人LMR Partners LLP |
| 0.64% | 0.13% | #35 | $1.71亿 | 244.7万股 | $5,762.7万 | 113.4万股 | +131.2万股+115.69% | 加仓 |
| Merck & Co., Inc. |
| 30.71% | 33.56% | #2 | $1.62亿 | 230.8万股 | $1.17亿 | 230.8万股 | 00.00% | 持仓不变 |
| BAMCO(巴伦基金)BAMCO INC /NY/ |
| 0.21% | — | #70 | $1.39亿 | 198.9万股 | $0 | 0股 | +198.9万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.03% | 0.03% | #216 | $1.39亿 | 198.8万股 | $9,988.9万 | 196.6万股 | +2.1万股+1.08% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.18% | 0.16% | #81 | $1.26亿 | 179.5万股 | $1.00亿 | 197.7万股 | -18.2万股-9.22% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.02% | 0.02% | #278 | $1.19亿 | 170.2万股 | $8,591.3万 | 169.1万股 | +1.0万股+0.62% | 加仓 |
| 巴克莱BARCLAYS PLC |
| 0.02% | 0.01% | #257 | $1.16亿 | 165.8万股 | $5,442.0万 | 107.1万股 | +58.7万股+54.75% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.02% | 0.02% | #282 | $1.07亿 | 152.2万股 | $8,232.5万 | 162.1万股 | -9.9万股-6.09% | 减仓 |
| 加拿大国家银行NATIONAL BANK OF CANADA /FI/ |
| 0.09% | 0.09% | #119 | $9,977.5万 | 142.5万股 | $9,230.2万 | 181.7万股 | -39.2万股-21.58% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #434 | $9,872.0万 | 141.0万股 | $5,010.7万 | 98.6万股 | +42.3万股+42.92% | 加仓 |
| 道格拉斯·莱恩联合Douglas Lane & Associates, LLC |
| 1.28% | 0.98% | #18 | $9,408.4万 | 134.3万股 | $6,662.3万 | 131.1万股 | +3.2万股+2.44% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.09% | 0.12% | #118 | $9,339.0万 | 133.3万股 | $1.07亿 | 210.6万股 | -77.2万股-36.67% | 减仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.05% | 0.99% | #24 | $7,003.0万 | 100.0万股 | $5,080.0万 | 100.0万股 | 00.00% | 持仓不变 |
| 安联资产管理Allianz Asset Management GmbH |
| 0.06% | 0.05% | #147 | $6,898.2万 | 99.0万股 | $5,023.7万 | 98.9万股 | +989股+0.10% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| 0.02% | 0.01% | #272 | $6,887.1万 | 98.3万股 | $4,116.1万 | 81.0万股 | +17.3万股+21.38% | 加仓 |
| Affinity Asset Advisors, LLC |
| 3.09% | 2.1% | #10 | $6,827.9万 | 97.5万股 | $4,064.0万 | 80.0万股 | +17.5万股+21.88% | 加仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| 0.01% | 0.01% | #381 | $6,613.9万 | 94.4万股 | $5,272.3万 | 103.8万股 | -9.3万股-9.00% | 减仓 |
| Walleye交易Walleye Trading LLC |
| 0.08% | 0.1% | #129 | $6,577.7万 | 93.9万股 | $5,853.5万 | 115.2万股 | -21.3万股-18.48% | 减仓 |
| 东方汇理Amundi |
| 0.02% | 0.01% | #332 | $6,224.1万 | 88.9万股 | $4,596.5万 | 90.5万股 | -1.6万股-1.77% | 减仓 |
| 英国法通集团Legal & General Group Plc |
| 0.01% | 0.01% | #353 | $6,184.2万 | 88.3万股 | $3,814.2万 | 75.1万股 | +13.2万股+17.61% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #521 | $5,952.0万 | 83.7万股 | $6,354.8万 | 131.8万股 | -48.0万股-36.44% | 减仓 |
