| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.55% | 2.2% | #4 | $1.79亿 | 802.1万股 | $2.08亿 | 802.1万股 | 00.00% | 持仓不变 |
| NEA Management Company, LLC |
| 10.36% | 10.89% | #1 | $1.65亿 | 739.2万股 | $1.92亿 | 739.2万股 | 00.00% | 持仓不变 |
| Sands Capital Alternatives, LLC |
| 9.07% | 15.38% | #2 | $5,565.0万 | 250.0万股 | $6,477.5万 | 250.0万股 | 00.00% | 持仓不变 |
| Samsara BioCapital, LLC |
| 3.86% | 5.31% | #3 | $4,696.8万 | 211.0万股 | $5,466.9万 | 211.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #24 | $1,584.3万 | 71.2万股 | $375.0万 | 14.5万股 | +56.7万股+391.72% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #13 | $1,500.6万 | 67.4万股 | $1,825.3万 | 70.4万股 | -3.0万股-4.30% | 减仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.35% | 0.48% | #5 | $1,491.4万 | 67.0万股 | $1,727.6万 | 66.7万股 | +3,240股+0.49% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #16 | $1,363.4万 | 63.0万股 | $1,348.7万 | 57.7万股 | +5.3万股+9.12% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.13% | 0.17% | #7 | $1,224.3万 | 55.0万股 | $1,425.1万 | 55.0万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #10 | $1,129.2万 | 50.7万股 | $1,214.6万 | 46.9万股 | +3.8万股+8.20% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.02% | 0.01% | #9 | $1,097.6万 | 49.3万股 | $571.2万 | 22.0万股 | +27.3万股+123.66% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $967.0万 | 43.4万股 | $1,126.6万 | 43.5万股 | -390股-0.09% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $617.5万 | 27.7万股 | $328.1万 | 12.7万股 | +15.1万股+119.16% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #14 | $519.6万 | 23.3万股 | $777.3万 | 30.0万股 | -6.7万股-22.20% | 减仓 |
| Affinity Asset Advisors, LLC |
| 0.13% | 0.33% | #6 | $292.9万 | 13.2万股 | $647.8万 | 25.0万股 | -11.8万股-47.37% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #35 | $261.7万 | 11.8万股 | $44.7万 | 1.7万股 | +10.0万股+581.51% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #23 | $190.7万 | 8.6万股 | $154.4万 | 6.0万股 | +2.6万股+43.74% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #26 | $183.5万 | 8.2万股 | $54.1万 | 2.1万股 | +6.2万股+295.22% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $168.8万 | 7.6万股 | $9.5万 | 3,680股 | +7.2万股+1,960.11% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #21 | $152.5万 | 6.8万股 | $154.9万 | 6.0万股 | +8,716股+14.58% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #12 | $126.9万 | 5.7万股 | $147.7万 | 5.7万股 | 00.00% | 持仓不变 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #15 | $105.9万 | 4.8万股 | $123.3万 | 4.8万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #28 | $101.7万 | 4.6万股 | $115.2万 | 4.4万股 | +1,191股+2.68% | 加仓 |
| ALPS顾问ALPS ADVISORS INC |
| <0.01% | — | #11 | $75.5万 | 3.4万股 | $0 | 0股 | +3.4万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #33 | $53.3万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| Virtus Investment Advisers, LLC |
| 0.09% | — | #8 | $39.5万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #34 | $32.6万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #25 | $27.8万 | 1.3万股 | $30.8万 | 1.2万股 | +634股+5.34% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #29 | $26.4万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #45 | $25.0万 | 1.1万股 | $72.6万 | 2.8万股 | -1.7万股-59.98% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #37 | $24.4万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #41 | $21.9万 | 9,852股 | $0 | 0股 | +9,852股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #47 | $19.9万 | 8,921股 | $0 | 0股 | +8,921股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #43 | $17.7万 | 7,945股 | $1.2万 | 455股 | +7,490股+1,646.15% | 加仓 |
| 大都会人寿投资管理MetLife Investment Management, LLC |
| <0.01% | — | #17 | $15.6万 | 6,986股 | $0 | 0股 | +6,986股 | 新买入 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #31 | $12.0万 | 5,400股 | $0 | 0股 | +5,400股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | — | #39 | $11.6万 | 5,190股 | $0 | 0股 | +5,190股 | 新买入 |
| 未来资产环球ETFMIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #32 | $11.4万 | 5,103股 | $0 | 0股 | +5,103股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #38 | $10.3万 | 4,627股 | $12.8万 | 4,927股 | -300股-6.09% | 减仓 |
| 新泽西州警察消防退休系统Police & Firemen's Retirement System of New Jersey |
| <0.01% | — | #19 | $7.3万 | 3,268股 | $0 | 0股 | +3,268股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #48 | $4.9万 | 2,209股 | $3,627 | 140股 | +2,069股+1,477.86% | 加仓 |
| 俄亥俄州教师退休系统(STRS)STRS OHIO |
| <0.01% | — | #30 | $4.9万 | 2,200股 | $0 | 0股 | +2,200股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #44 | $4.5万 | 2,016股 | $0 | 0股 | +2,016股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | — | #52 | $3.3万 | 1,497股 | $0 | 0股 | +1,497股 | 新买入 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | — | #49 | $2.4万 | 1,087股 | $0 | 0股 | +1,087股 | 新买入 |
| Ameritas Investment Partners, Inc. |
| <0.01% | — | #18 | $2.2万 | 1,006股 | $0 | 0股 | +1,006股 | 新买入 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | — | #46 | $2.0万 | 886股 | $0 | 0股 | +886股 | 新买入 |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #20 | $1.7万 | 750股 | $0 | 0股 | +750股 | 新买入 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #51 | $1.3万 | 589股 | $2,000 | 85股 | +504股+592.94% | 加仓 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
| <0.01% | — | #50 | $3,406 | 153股 | $0 | 0股 | +153股 | 新买入 |
