| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #24 | $3,004.8万 | 3,417.3万股 | $0 | 0股 | +3,417.3万股 | 新买入 |
| BVF INC/IL |
| 0.63% | 0.81% | #3 | $2,457.1万 | 2,816.5万股 | $2,538.3万 | 1,952.5万股 | +864.0万股+44.25% | 加仓 |
| Maverick资本MAVERICK CAPITAL LTD |
| 0.15% | 0.28% | #9 | $1,655.0万 | 1,897.1万股 | $2,466.2万 | 1,897.1万股 | 00.00% | 持仓不变 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.24% | 0.53% | #5 | $1,613.1万 | 1,849.1万股 | $2,711.7万 | 2,085.9万股 | -236.9万股-11.36% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #60 | $1,407.6万 | 1,613.5万股 | $556.6万 | 428.2万股 | +1,185.3万股+276.83% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $915.3万 | 1,049.7万股 | $1,309.7万 | 1,007.4万股 | +42.2万股+4.19% | 加仓 |
| M28 Capital Management LP |
| 17.11% | 22.35% | #1 | $806.8万 | 924.8万股 | $1,202.3万 | 924.8万股 | 00.00% | 持仓不变 |
| Saturn V Capital Management LP |
| 1.05% | 2.58% | #2 | $732.1万 | 839.2万股 | $1,423.4万 | 1,094.9万股 | -255.7万股-23.35% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.23% | 0.41% | #6 | $672.5万 | 770.9万股 | $1,002.1万 | 770.9万股 | 00.00% | 持仓不变 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #26 | $658.0万 | 754.2万股 | $5.7万 | 4.4万股 | +749.8万股+17,067.97% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #57 | $500.0万 | 573.1万股 | $85.8万 | 78.0万股 | +495.1万股+634.62% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $472.9万 | 541.9万股 | $321.1万 | 246.9万股 | +295.0万股+119.48% | 加仓 |
| Siren, L.L.C. |
| 0.09% | 0.14% | #16 | $436.2万 | 500.0万股 | $520.0万 | 400.0万股 | +100.0万股+25.00% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.02% | 0.08% | #22 | $419.3万 | 480.7万股 | $1,096.8万 | 843.7万股 | -363.0万股-43.03% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.15% | 0.29% | #7 | $332.2万 | 380.7万股 | $496.9万 | 382.2万股 | -1.5万股-0.39% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $328.6万 | 376.7万股 | $218.4万 | 168.0万股 | +208.6万股+124.15% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | 0.01% | #29 | $319.4万 | 366.1万股 | $476.0万 | 366.1万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #70 | $301.6万 | 345.7万股 | $901.6万 | 693.6万股 | -347.8万股-50.15% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #34 | $289.7万 | 332.0万股 | $349.3万 | 268.7万股 | +63.3万股+23.56% | 加仓 |
| Ikarian Capital, LLC |
| 0.25% | 0.28% | #4 | $231.8万 | 265.7万股 | $345.4万 | 265.7万股 | 00.00% | 持仓不变 |
| Redmile Group, LLC |
| 0.15% | 0.23% | #8 | $226.6万 | 259.8万股 | $344.3万 | 264.9万股 | -5.1万股-1.92% | 减仓 |
| 683 Capital Management, LLC |
| 0.11% | 0.17% | #12 | $216.6万 | 248.3万股 | $327.0万 | 251.5万股 | -3.2万股-1.29% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #40 | $203.6万 | 233.3万股 | $256.1万 | 197.0万股 | +36.4万股+18.47% | 加仓 |
| Eversept Partners, LP |
| 0.1% | 0.16% | #13 | $195.2万 | 223.7万股 | $295.9万 | 227.6万股 | -3.9万股-1.73% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | <0.01% | #35 | $150.2万 | 172.1万股 | $262.5万 | 201.9万股 | -29.8万股-14.75% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #64 | $140.5万 | 161.0万股 | $59.8万 | 46.0万股 | +115.0万股+249.98% | 加仓 |
| Boxer Capital Management, LLC |
| 0.1% | 0.26% | #14 | $130.9万 | 150.0万股 | $195.0万 | 150.0万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #56 | $127.2万 | 145.9万股 | $171.4万 | 131.9万股 | +14.0万股+10.64% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #80 | $123.6万 | 141.8万股 | $0 | 0股 | +141.8万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $105.2万 | 120.6万股 | $456.5万 | 351.2万股 | -230.6万股-65.67% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #74 | $92.0万 | 105.6万股 | $313.8万 | 241.4万股 | -135.7万股-56.23% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #42 | $86.8万 | 99.5万股 | $110.0万 | 84.6万股 | +14.9万股+17.61% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #73 | $85.4万 | 97.9万股 | $339.5万 | 261.1万股 | -163.3万股-62.53% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #61 | $68.8万 | 79.1万股 | $76.1万 | 58.5万股 | +20.5万股+35.08% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #25 | $67.6万 | 77.5万股 | $100.7万 | 77.5万股 | 00.00% | 持仓不变 |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | 0.03% | #21 | $57.8万 | 66.2万股 | $42.6万 | 32.7万股 | +33.5万股+102.18% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #78 | $48.2万 | 55.2万股 | $79.9万 | 61.5万股 | -6.2万股-10.16% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #72 | $45.2万 | 51.8万股 | $3.5万 | 2.7万股 | +49.1万股+1,805.24% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #81 | $41.0万 | 47.0万股 | $15.3万 | 11.8万股 | +35.2万股+298.02% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #86 | $39.7万 | 45.5万股 | $49.5万 | 38.0万股 | +7.4万股+19.48% | 加仓 |
| 康托·菲茨杰拉德CANTOR FITZGERALD, L. P. |
| <0.01% | — | #30 | $39.3万 | 45.0万股 | $0 | 0股 | +45.0万股 | 新买入 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.01% | 0.03% | #23 | $37.4万 | 42.9万股 | $55.8万 | 42.9万股 | 00.00% | 持仓不变 |
| Virtus Investment Advisers, LLC |
| 0.09% | 0.04% | #17 | $37.1万 | 42.5万股 | $15.3万 | 11.8万股 | +30.7万股+261.53% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #95 | $31.1万 | 35.7万股 | $125.1万 | 96.2万股 | -60.5万股-62.91% | 减仓 |
| Birchview Capital, LP |
| 0.13% | — | #11 | $29.9万 | 34.2万股 | $0 | 0股 | +34.2万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #79 | $24.5万 | 28.0万股 | $0 | 0股 | +28.0万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #59 | $20.2万 | 23.1万股 | $106.6万 | 82.0万股 | -58.8万股-71.77% | 减仓 |
| MML投资者服务MML INVESTORS SERVICES, LLC |
| <0.01% | <0.01% | #54 | $17.8万 | 20.4万股 | $28.9万 | 22.2万股 | -1.7万股-7.88% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #105 | $15.4万 | 17.7万股 | $122.1万 | 93.9万股 | -76.2万股-81.19% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #92 | $15.4万 | 17.7万股 | $325 | 250股 | +17.6万股+70,510.40% | 加仓 |
