| Nantahala 资本管理Nantahala Capital Management, LLC |
| 1.29% | 0.96% | #5 | $3,887.8万 | 560.2万股 | $2,620.9万 | 637.7万股 | -77.5万股-12.15% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $3,359.5万 | 484.1万股 | $1,763.3万 | 429.0万股 | +55.0万股+12.83% | 加仓 |
| BRAIDWELL LP |
| 0.81% | 0.43% | #6 | $2,189.7万 | 315.5万股 | $1,276.2万 | 310.5万股 | +5.0万股+1.61% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.4% | 0.28% | #11 | $1,825.7万 | 263.1万股 | $1,081.2万 | 263.1万股 | 00.00% | 持仓不变 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.26% | 0.1% | #12 | $1,706.7万 | 245.9万股 | $528.9万 | 128.7万股 | +117.2万股+91.11% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #84 | $1,639.8万 | 236.3万股 | $1,015.3万 | 247.0万股 | -10.8万股-4.35% | 减仓 |
| Stonepine Capital Management, LLC |
| 2.17% | 3.59% | #3 | $1,418.6万 | 201.0万股 | $895.6万 | 217.9万股 | -16.9万股-7.75% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $1,240.8万 | 178.8万股 | $600.5万 | 146.1万股 | +32.7万股+22.36% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #85 | $1,177.9万 | 169.7万股 | $542.8万 | 132.1万股 | +37.7万股+28.51% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #72 | $1,116.5万 | 160.8万股 | $567.9万 | 138.1万股 | +22.7万股+16.44% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | — | #29 | $1,046.9万 | 150.9万股 | $0 | 0股 | +150.9万股 | 新买入 |
| 巅峰联合PINNACLE ASSOCIATES LTD |
| 0.11% | 0.06% | #16 | $1,032.2万 | 148.7万股 | $476.3万 | 115.9万股 | +32.8万股+28.33% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.12% | 0.1% | #15 | $996.6万 | 143.6万股 | $573.8万 | 139.6万股 | +4.0万股+2.87% | 加仓 |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.44% | 0.29% | #9 | $895.2万 | 129.0万股 | $515.7万 | 125.5万股 | +3.5万股+2.79% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #67 | $846.3万 | 121.9万股 | $446.5万 | 108.6万股 | +13.3万股+12.24% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.01% | <0.01% | #32 | $630.3万 | 90.8万股 | $245.8万 | 59.8万股 | +31.0万股+51.83% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.2% | 0.37% | #13 | $570.8万 | 82.2万股 | $922.8万 | 224.5万股 | -142.3万股-63.37% | 减仓 |
| Soviero Asset Management, LP |
| 2.25% | 1.4% | #2 | $534.4万 | 77.0万股 | $279.6万 | 68.0万股 | +9.0万股+13.17% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #69 | $522.4万 | 75.3万股 | $309.4万 | 75.3万股 | -202股-0.03% | 减仓 |
| AWH Capital, L.P. |
| 3.04% | 2.33% | #1 | $433.8万 | 62.5万股 | $256.9万 | 62.5万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #96 | $378.7万 | 54.6万股 | $196.1万 | 47.7万股 | +6.9万股+14.38% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #75 | $368.4万 | 53.1万股 | $211.9万 | 51.6万股 | +1.5万股+2.97% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #78 | $360.3万 | 51.9万股 | $323.6万 | 78.7万股 | -26.8万股-34.06% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #79 | $344.9万 | 49.7万股 | $194.1万 | 47.2万股 | +2.5万股+5.22% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.02% | 0.01% | #27 | $329.2万 | 47.4万股 | $194.9万 | 47.4万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $316.6万 | 45.6万股 | $174.5万 | 42.5万股 | +3.2万股+7.42% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #62 | $315.7万 | 45.5万股 | $181.5万 | 44.2万股 | +1.3万股+3.01% | 加仓 |
| Stifel金融STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #46 | $293.7万 | 42.3万股 | $188.4万 | 45.8万股 | -3.5万股-7.68% | 减仓 |
| CM Management, LLC |
| 1.76% | 1.37% | #4 | $277.6万 | 40.0万股 | $164.4万 | 40.0万股 | 00.00% | 持仓不变 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #56 | $233.8万 | 33.7万股 | $229.8万 | 55.9万股 | -22.2万股-39.74% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #42 | $210.0万 | 30.3万股 | $139.3万 | 33.9万股 | -3.6万股-10.75% | 减仓 |
| Walleye资本Walleye Capital LLC |
| 0.01% | — | #33 | $176.2万 | 25.4万股 | $0 | 0股 | +25.4万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #112 | $164.9万 | 23.8万股 | $163.2万 | 26.6万股 | -2.8万股-10.60% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #81 | $162.1万 | 23.4万股 | $45.9万 | 11.2万股 | +12.2万股+109.33% | 加仓 |
| 美国国家慈善信托National Philanthropic Trust |
| 0.02% | — | #26 | $138.8万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| DIADEMA PARTNERS LP |
| 0.17% | 0.09% | #14 | $138.8万 | 20.0万股 | $51.5万 | 12.5万股 | +7.5万股+59.74% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #52 | $137.2万 | 19.8万股 | $65.1万 | 15.8万股 | +3.9万股+24.82% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #92 | $117.9万 | 17.0万股 | $0 | 0股 | +17.0万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #94 | $113.0万 | 16.3万股 | $58.8万 | 14.3万股 | +2.0万股+13.75% | 加仓 |
| Krensavage Asset Management, LLC |
| 0.42% | 0.25% | #10 | $109.6万 | 15.8万股 | $64.9万 | 15.8万股 | 00.00% | 持仓不变 |
| KVP Capital Advisors, LP |
| 0.76% | — | #7 | $104.1万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | 0.01% | #34 | $101.5万 | 14.6万股 | $154.2万 | 37.5万股 | -22.9万股-61.00% | 减仓 |
| Potomac Capital Management, Inc. |
| 0.67% | 0.51% | #8 | $98.2万 | 14.2万股 | $58.2万 | 14.2万股 | 00.00% | 持仓不变 |
| 法国外贸银行(Natixis)NATIXIS |
| <0.01% | <0.01% | #38 | $98.2万 | 14.1万股 | $58.1万 | 14.1万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #110 | $95.6万 | 13.8万股 | $40.3万 | 9.8万股 | +4.0万股+40.62% | 加仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| <0.01% | <0.01% | #59 | $88.9万 | 12.8万股 | $51.3万 | 12.5万股 | +3,317股+2.66% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #119 | $83.7万 | 12.1万股 | $78.7万 | 19.1万股 | -7.1万股-37.02% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | — | #120 | $77.0万 | 11.1万股 | $0 | 0股 | +11.1万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| 0.01% | <0.01% | #31 | $73.9万 | 10.7万股 | $28.4万 | 6.9万股 | +3.7万股+54.10% | 加仓 |
| ANGELES WEALTH MANAGEMENT, LLC |
| 0.03% | — | #22 | $73.2万 | 10.6万股 | $0 | 0股 | +10.6万股 | 新买入 |
