| Caligan Partners LP |
| 1.17% | 1.84% | #4 | $2,497.7万 | 607.7万股 | $2,764.1万 | 607.5万股 | +2,056股+0.03% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.04% | #20 | $2,478.2万 | 603.0万股 | $2,743.5万 | 603.0万股 | 00.00% | 持仓不变 |
| BIOS Capital Management, LP |
| 36.33% | 31.7% | #1 | $1,513.9万 | 368.3万股 | $1,676.0万 | 368.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #61 | $1,280.9万 | 311.6万股 | $67.2万 | 14.8万股 | +296.9万股+2,009.44% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #26 | $1,269.1万 | 308.8万股 | $1,236.7万 | 271.8万股 | +37.0万股+13.61% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.42% | 0.28% | #7 | $1,258.2万 | 306.1万股 | $765.0万 | 168.1万股 | +138.0万股+82.08% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $1,216.0万 | 295.9万股 | $1,114.7万 | 245.0万股 | +50.9万股+20.76% | 加仓 |
| Boxer Capital Management, LLC |
| 0.87% | 1.34% | #5 | $1,157.0万 | 281.5万股 | $1,023.8万 | 225.0万股 | +56.5万股+25.11% | 加仓 |
| Trails Edge Capital Partners, LP |
| 1.79% | 0.52% | #2 | $1,127.6万 | 274.4万股 | $227.5万 | 50.0万股 | +224.4万股+448.73% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $946.2万 | 230.2万股 | $1,196.8万 | 263.0万股 | -32.8万股-12.48% | 减仓 |
| GREAT POINT PARTNERS LLC |
| 1.53% | 0.34% | #3 | $809.7万 | 197.0万股 | $147.6万 | 32.4万股 | +164.6万股+507.44% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #33 | $799.6万 | 194.6万股 | $1,052.6万 | 231.3万股 | -36.8万股-15.90% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.34% | 0.5% | #9 | $733.1万 | 178.4万股 | $841.3万 | 184.9万股 | -6.5万股-3.53% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #47 | $627.7万 | 152.7万股 | $148.7万 | 32.7万股 | +120.0万股+367.32% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.02% | #25 | $589.7万 | 143.5万股 | $616.1万 | 135.4万股 | +8.1万股+5.96% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #56 | $562.3万 | 136.8万股 | $245.1万 | 53.8万股 | +82.9万股+154.06% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.07% | 0.07% | #17 | $488.9万 | 119.0万股 | $541.0万 | 118.9万股 | +402股+0.03% | 加仓 |
| Opaleye Management Inc. |
| 0.42% | 0.3% | #8 | $462.4万 | 112.5万股 | $225.1万 | 112.0万股 | +5,000股+0.45% | 加仓 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.11% | — | #11 | $414.0万 | 100.7万股 | $0 | 0股 | +100.7万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #68 | $324.7万 | 79.0万股 | $91.0万 | 20.0万股 | +59.0万股+295.16% | 加仓 |
| Bleichroeder LP |
| 0.54% | 0.58% | #6 | $302.8万 | 73.7万股 | $335.3万 | 73.7万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #52 | $281.1万 | 68.4万股 | $117.2万 | 25.8万股 | +42.6万股+165.44% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #54 | $273.6万 | 66.6万股 | $55.0万 | 12.1万股 | +54.5万股+450.59% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #67 | $191.1万 | 46.5万股 | $4.7万 | 2.9万股 | +43.6万股+1,525.18% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #58 | $181.7万 | 44.2万股 | $43.0万 | 9.4万股 | +34.8万股+368.31% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #51 | $168.7万 | 41.0万股 | $128.2万 | 28.2万股 | +12.9万股+45.63% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #76 | $152.9万 | 37.2万股 | $0 | 0股 | +37.2万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #41 | $136.0万 | 33.1万股 | $0 | 0股 | +33.1万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #43 | $104.4万 | 25.4万股 | $49.4万 | 10.9万股 | +14.5万股+133.76% | 加仓 |
| AWM Investment Company, Inc. |
| 0.08% | — | #16 | $95.6万 | 23.3万股 | $0 | 0股 | +23.3万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #73 | $86.1万 | 21.0万股 | $91.7万 | 20.2万股 | +8,085股+4.01% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #81 | $80.9万 | 19.7万股 | $411.7万 | 90.5万股 | -70.8万股-78.24% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #69 | $67.8万 | 16.5万股 | $15.9万 | 3.5万股 | +13.0万股+371.58% | 加仓 |
| Mink Brook Asset Management LLC |
| 0.29% | 1.5% | #10 | $66.3万 | 16.1万股 | $268.7万 | 59.1万股 | -42.9万股-72.70% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | <0.01% | #30 | $59.2万 | 14.4万股 | $7.6万 | 1.7万股 | +12.7万股+762.64% | 加仓 |
| Seven Fleet Capital Management LP |
| 0.1% | 0.19% | #12 | $58.8万 | 14.3万股 | $61.1万 | 13.4万股 | +8,895股+6.63% | 加仓 |
| Creative Planning财富管理Creative Planning |
| <0.01% | <0.01% | #55 | $52.8万 | 12.8万股 | $58.4万 | 12.8万股 | 00.00% | 持仓不变 |
| Texas Capital Bank Wealth Management Services Inc |
| 0.03% | 0.02% | #22 | $50.4万 | 12.3万股 | $40.3万 | 8.9万股 | +3.4万股+38.45% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #71 | $50.3万 | 12.2万股 | $0 | 0股 | +12.2万股 | 新买入 |
| Stonepine Capital Management, LLC |
| 0.06% | 0.13% | #18 | $41.4万 | 10.1万股 | $31.3万 | 6.9万股 | +3.2万股+46.63% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | — | #37 | $39.0万 | 9.5万股 | $0 | 0股 | +9.5万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #75 | $29.3万 | 7.1万股 | $0 | 0股 | +7.1万股 | 新买入 |
| Palogic Value Management, L.P. |
| 0.09% | 0.12% | #15 | $26.8万 | 6.5万股 | $29.6万 | 6.5万股 | +88股+0.14% | 加仓 |
| Aureus Asset Management, LLC |
| 0.01% | — | #27 | $23.9万 | 5.8万股 | $0 | 0股 | +5.8万股 | 新买入 |
| Regency Capital Management Inc.\DE |
| 0.09% | 0.14% | #13 | $23.8万 | 5.8万股 | $30.9万 | 6.8万股 | -1.0万股-14.71% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #95 | $22.6万 | 5.5万股 | $30.5万 | 6.7万股 | -1.2万股-17.92% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #80 | $21.9万 | 5.3万股 | $0 | 0股 | +5.3万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | — | #92 | $21.9万 | 5.3万股 | $0 | 0股 | +5.3万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #88 | $21.6万 | 5.3万股 | $1.7万 | 3,785股 | +4.9万股+1,290.57% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #64 | $21.2万 | 5.1万股 | $0 | 0股 | +5.1万股 | 新买入 |
