| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.99% | 0.29% | #4 | $5,259.1万 | 412.8万股 | $1,446.4万 | 225.3万股 | +187.5万股+83.22% | 加仓 |
| Boxer Capital Management, LLC |
| 3.02% | — | #2 | $4,012.2万 | 314.9万股 | $0 | 0股 | +314.9万股 | 新买入 |
| Atlas Venture Life Science Advisors, LLC |
| 3.93% | 1.7% | #1 | $3,461.6万 | 271.7万股 | $1,343.1万 | 209.2万股 | +62.5万股+29.87% | 加仓 |
| BVF INC/IL |
| 0.77% | — | #6 | $2,993.9万 | 235.0万股 | $0 | 0股 | +235.0万股 | 新买入 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.26% | — | #11 | $2,971.6万 | 233.2万股 | $0 | 0股 | +233.2万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.02% | — | #17 | $1,494.9万 | 117.3万股 | $0 | 0股 | +117.3万股 | 新买入 |
| Opaleye Management Inc. |
| 1.07% | 1.06% | #3 | $1,186.1万 | 93.1万股 | $806.5万 | 125.6万股 | -32.5万股-25.89% | 减仓 |
| Logos Global Management LP |
| 0.44% | — | #9 | $1,019.2万 | 80.0万股 | $0 | 0股 | +80.0万股 | 新买入 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.24% | — | #12 | $934.8万 | 73.4万股 | $0 | 0股 | +73.4万股 | 新买入 |
| Ikarian Capital, LLC |
| 0.85% | — | #5 | $802.6万 | 63.0万股 | $0 | 0股 | +63.0万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $661.0万 | 51.9万股 | $196.7万 | 30.6万股 | +21.2万股+69.32% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | — | #19 | $364.6万 | 28.6万股 | $0 | 0股 | +28.6万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #27 | $347.5万 | 27.3万股 | $12.1万 | 1.9万股 | +25.4万股+1,353.13% | 加仓 |
| Sanofi |
| 0.58% | 0.47% | #8 | $311.0万 | 24.4万股 | $156.7万 | 24.4万股 | 00.00% | 持仓不变 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $278.0万 | 21.8万股 | $110.6万 | 17.3万股 | +4.6万股+26.45% | 加仓 |
| ACORN CAPITAL ADVISORS, LLC |
| 0.75% | 0.57% | #7 | $275.4万 | 21.6万股 | $202.3万 | 31.5万股 | -9.9万股-31.39% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | — | #15 | $244.3万 | 19.2万股 | $0 | 0股 | +19.2万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #24 | $228.8万 | 18.0万股 | $132.8万 | 20.7万股 | -2.7万股-13.20% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #38 | $207.3万 | 16.3万股 | $42.1万 | 6.6万股 | +9.7万股+148.09% | 加仓 |
| MONIMUS CAPITAL MANAGEMENT, LP |
| 0.39% | 0.24% | #10 | $168.2万 | 13.2万股 | $86.2万 | 13.4万股 | -2,274股-1.69% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $156.4万 | 12.3万股 | $75.9万 | 11.8万股 | +4,538股+3.84% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #37 | $153.7万 | 12.1万股 | $9.9万 | 1.5万股 | +10.5万股+679.43% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #52 | $151.0万 | 11.9万股 | $55.3万 | 8.6万股 | +3.2万股+37.56% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #29 | $85.4万 | 6.7万股 | $33.7万 | 5.2万股 | +1.5万股+27.85% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $84.4万 | 6.6万股 | $32.1万 | 5.0万股 | +1.6万股+32.45% | 加仓 |
| 凯雷集团Carlyle Group Inc. |
| 0.01% | 0.07% | #21 | $76.9万 | 6.0万股 | $708.0万 | 110.3万股 | -104.2万股-94.53% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #53 | $66.5万 | 5.2万股 | $26.7万 | 4.2万股 | +1.1万股+25.77% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #31 | $63.2万 | 5.0万股 | $27.2万 | 4.2万股 | +7,236股+17.09% | 加仓 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #22 | $46.4万 | 3.6万股 | $0 | 0股 | +3.6万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #20 | $44.1万 | 3.5万股 | $8.1万 | 1.3万股 | +2.2万股+174.42% | 加仓 |
| DAFNA Capital Management LLC |
| 0.08% | — | #14 | $41.9万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| Knott David M Jr |
| 0.21% | — | #13 | $38.7万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 0.02% | 0.01% | #18 | $35.4万 | 2.8万股 | $17.8万 | 2.8万股 | 00.00% | 持仓不变 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #33 | $30.3万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #47 | $30.1万 | 2.4万股 | $16.1万 | 2.5万股 | -1,402股-5.60% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #44 | $30.1万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #51 | $29.7万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| MANGROVE PARTNERS IM, LLC |
| 0.02% | — | #16 | $28.2万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| LPL金融LPL Financial LLC |
| <0.01% | — | #45 | $23.1万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| Cambridge Investment Research Advisors, Inc. |
| <0.01% | <0.01% | #30 | $23.0万 | 1.8万股 | $22.5万 | 3.5万股 | -1.7万股-48.38% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #32 | $20.3万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #50 | $19.1万 | 1.5万股 | $1,733 | 270股 | +1.5万股+5,458.52% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #35 | $15.7万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| <0.01% | — | #28 | $14.4万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #46 | $13.9万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | — | #26 | $13.9万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #61 | $8.2万 | 6,456股 | $2.2万 | 1.1万股 | -4,887股-43.08% | 减仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #48 | $6.1万 | 4,824股 | $1.2万 | 1,915股 | +2,909股+151.91% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #65 | $4.3万 | 3,388股 | $2.2万 | 3,400股 | -12股-0.35% | 减仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | — | #55 | $3.7万 | 2,888股 | $0 | 0股 | +2,888股 | 新买入 |
