| Artal Group S.A. |
| 45.15% | 23.89% | #1 | $4.20亿 | 1.75亿股 | $2.41亿 | 1.55亿股 | +2,042.2万股+13.20% | 加仓 |
| 富达投资FMR LLC |
| 0.01% | <0.01% | #25 | $1.24亿 | 5,178.2万股 | $7,028.8万 | 4,505.6万股 | +672.6万股+14.93% | 加仓 |
| Siren, L.L.C. |
| 2.15% | 1.92% | #3 | $1.06亿 | 4,430.4万股 | $6,911.3万 | 4,430.4万股 | 00.00% | 持仓不变 |
| 塞萨资本Sessa Capital IM, L.P. |
| 0.76% | 0.51% | #4 | $4,550.6万 | 1,896.1万股 | $2,794.4万 | 1,791.3万股 | +104.8万股+5.85% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #56 | $4,163.7万 | 1,734.9万股 | $518.3万 | 332.2万股 | +1,402.7万股+422.20% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $2,376.3万 | 990.1万股 | $1,485.0万 | 951.9万股 | +38.2万股+4.01% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.02% | 0.02% | #17 | $1,980.3万 | 825.1万股 | $1,219.1万 | 781.5万股 | +43.7万股+5.59% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #51 | $1,499.0万 | 624.4万股 | $494.6万 | 316.9万股 | +307.5万股+97.04% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #69 | $1,180.3万 | 491.8万股 | $150.4万 | 96.4万股 | +395.4万股+410.12% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #80 | $565.9万 | 235.8万股 | $85.3万 | 54.7万股 | +181.1万股+331.35% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #60 | $477.2万 | 198.8万股 | $263.2万 | 168.7万股 | +30.1万股+17.84% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #58 | $472.5万 | 196.9万股 | $77.2万 | 49.5万股 | +147.4万股+297.97% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #54 | $469.6万 | 195.7万股 | $204.6万 | 131.1万股 | +64.5万股+49.22% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #50 | $392.3万 | 163.5万股 | $207.8万 | 133.2万股 | +30.2万股+22.69% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #79 | $332.0万 | 138.3万股 | $431.5万 | 276.6万股 | -138.3万股-50.00% | 减仓 |
| Ishara Investments LP |
| 2.21% | 1.33% | #2 | $305.0万 | 127.1万股 | $140.7万 | 90.2万股 | +36.9万股+40.91% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $272.2万 | 113.4万股 | $771.4万 | 494.5万股 | -381.1万股-77.06% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #26 | $270.5万 | 112.7万股 | $249.7万 | 160.1万股 | -47.4万股-29.58% | 减仓 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| <0.01% | <0.01% | #31 | $231.2万 | 96.3万股 | $120.5万 | 77.3万股 | +19.1万股+24.68% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.08% | 0.07% | #6 | $180.0万 | 75.0万股 | $117.0万 | 75.0万股 | 00.00% | 持仓不变 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #32 | $167.2万 | 69.7万股 | $69.3万 | 44.5万股 | +25.1万股+56.44% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #84 | $164.3万 | 68.5万股 | $387.4万 | 248.3万股 | -179.8万股-72.43% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #43 | $154.4万 | 64.3万股 | $187.1万 | 120.0万股 | -55.6万股-46.36% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #72 | $140.8万 | 58.7万股 | $0 | 0股 | +58.7万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #94 | $139.9万 | 58.3万股 | $505.3万 | 323.9万股 | -265.6万股-82.00% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #82 | $136.5万 | 56.9万股 | $4.3万 | 2.7万股 | +54.1万股+1,971.11% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #98 | $121.9万 | 50.8万股 | $79.9万 | 51.2万股 | -4,355股-0.85% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #96 | $116.5万 | 48.6万股 | $167.0万 | 107.1万股 | -58.5万股-54.64% | 减仓 |
| 隆巴德·奥迪耶Compagnie Lombard Odier SCmA |
| 0.01% | 0.01% | #21 | $115.2万 | 48.0万股 | $79.6万 | 51.0万股 | -3.0万股-5.88% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #105 | $101.1万 | 42.1万股 | $82.1万 | 52.6万股 | -10.5万股-19.92% | 减仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.06% | 0.09% | #8 | $95.3万 | 39.7万股 | $145.1万 | 93.0万股 | -53.3万股-57.29% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #88 | $93.0万 | 38.7万股 | $16.5万 | 10.5万股 | +28.2万股+267.33% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #23 | $85.9万 | 35.8万股 | $49.1万 | 31.5万股 | +4.3万股+13.75% | 加仓 |
| Janney Montgomery Scott LLC |
| <0.01% | — | #38 | $70.9万 | 29.6万股 | $0 | 0股 | +29.6万股 | 新买入 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | — | #71 | $61.9万 | 25.8万股 | $0 | 0股 | +25.8万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #63 | $61.7万 | 25.7万股 | $0 | 0股 | +25.7万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #89 | $59.4万 | 24.8万股 | $0 | 0股 | +24.8万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #100 | $55.3万 | 23.0万股 | $1.2万 | 7,760股 | +22.3万股+2,869.97% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #110 | $49.1万 | 20.4万股 | $0 | 0股 | +20.4万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #103 | $43.1万 | 18.0万股 | $0 | 0股 | +18.0万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #91 | $42.0万 | 17.5万股 | $26.0万 | 16.6万股 | +8,807股+5.29% | 加仓 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #57 | $42.0万 | 17.5万股 | $28.9万 | 18.5万股 | -9,993股-5.40% | 减仓 |
| Virtus Investment Advisers, LLC |
| 0.1% | — | #5 | $40.9万 | 17.0万股 | $0 | 0股 | +17.0万股 | 新买入 |
| Headlands Technologies LLC |
| 0.04% | 0.03% | #10 | $40.1万 | 16.7万股 | $29.8万 | 19.1万股 | -2.4万股-12.61% | 减仓 |
| Ikarian Capital, LLC |
| 0.04% | 0.02% | #11 | $39.5万 | 16.5万股 | $25.7万 | 16.5万股 | 00.00% | 持仓不变 |
| Quarry LP |
| 0.03% | 0.03% | #14 | $37.5万 | 15.6万股 | $17.2万 | 11.0万股 | +4.6万股+41.99% | 加仓 |
| 大都会人寿投资管理MetLife Investment Management, LLC |
| <0.01% | — | #34 | $35.1万 | 14.6万股 | $0 | 0股 | +14.6万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #130 | $31.9万 | 13.3万股 | $22.8万 | 16.9万股 | -3.6万股-21.37% | 减仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| <0.01% | — | #47 | $31.7万 | 13.2万股 | $0 | 0股 | +13.2万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #131 | $29.0万 | 11.0万股 | $0 | 0股 | +11.0万股 | 新买入 |
