| Cormorant Asset Management, LP |
| 2.32% | 1.01% | #3 | $4,575.0万 | 397.8万股 | $2,005.3万 | 289.8万股 | +108.0万股+37.28% | 加仓 |
| Venrock Adviser, LLC |
| 1.12% | 0.83% | #5 | $3,694.6万 | 321.3万股 | $2,223.2万 | 321.3万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.01% | #20 | $3,520.9万 | 306.2万股 | $607.5万 | 87.8万股 | +218.4万股+248.77% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.03% | — | #25 | $2,461.8万 | 214.1万股 | $0 | 0股 | +214.1万股 | 新买入 |
| MPM BioImpact LLC |
| 1.36% | — | #4 | $2,226.7万 | 193.6万股 | $0 | 0股 | +193.6万股 | 新买入 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.31% | — | #12 | $2,062.2万 | 179.3万股 | $0 | 0股 | +179.3万股 | 新买入 |
| Casdin Capital, LLC |
| 0.72% | 0.28% | #7 | $1,437.5万 | 125.0万股 | $372.6万 | 53.8万股 | +71.2万股+132.14% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.54% | 0.05% | #9 | $1,170.5万 | 101.8万股 | $81.6万 | 11.8万股 | +90.0万股+763.21% | 加仓 |
| Octagon Capital Advisors LP |
| 0.97% | — | #6 | $1,074.9万 | 93.5万股 | $0 | 0股 | +93.5万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #29 | $929.0万 | 80.8万股 | $471.8万 | 68.2万股 | +12.6万股+18.49% | 加仓 |
| BRAIDWELL LP |
| 0.34% | — | #11 | $914.5万 | 79.5万股 | $0 | 0股 | +79.5万股 | 新买入 |
| Squadron Capital Management LLC |
| 2.73% | 3.21% | #2 | $879.6万 | 76.5万股 | $875.5万 | 126.5万股 | -50.0万股-39.55% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.11% | — | #16 | $826.6万 | 71.9万股 | $0 | 0股 | +71.9万股 | 新买入 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 4.01% | 2.05% | #1 | $635.4万 | 55.3万股 | $287.1万 | 41.5万股 | +13.8万股+33.18% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #28 | $619.2万 | 53.8万股 | $372.6万 | 53.8万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | 0.01% | #26 | $524.1万 | 45.6万股 | $144.8万 | 20.9万股 | +24.6万股+117.78% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.16% | — | #15 | $466.4万 | 40.6万股 | $0 | 0股 | +40.6万股 | 新买入 |
| Freestone Grove合伙人Freestone Grove Partners LP |
| 0.03% | — | #24 | $457.1万 | 39.7万股 | $0 | 0股 | +39.7万股 | 新买入 |
| BOONE CAPITAL MANAGEMENT LLC |
| 0.7% | — | #8 | $297.1万 | 25.8万股 | $0 | 0股 | +25.8万股 | 新买入 |
| DAFNA Capital Management LLC |
| 0.53% | — | #10 | $275.5万 | 24.0万股 | $0 | 0股 | +24.0万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 0.08% | 0.06% | #18 | $176.9万 | 15.4万股 | $114.0万 | 16.5万股 | -1.1万股-6.62% | 减仓 |
| Seven Fleet Capital Management LP |
| 0.21% | — | #13 | $130.2万 | 11.3万股 | $0 | 0股 | +11.3万股 | 新买入 |
| DV Trading LLC |
| 0.04% | — | #21 | $130.2万 | 11.3万股 | $0 | 0股 | +11.3万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #30 | $108.2万 | 9.4万股 | $45.7万 | 6.6万股 | +2.8万股+42.58% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #35 | $99.7万 | 8.7万股 | $83.1万 | 12.0万股 | -3.3万股-27.84% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | — | #27 | $78.1万 | 6.8万股 | $0 | 0股 | +6.8万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #36 | $60.8万 | 5.3万股 | $84.6万 | 12.2万股 | -6.9万股-56.74% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #32 | $54.7万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| Tidal投资Tidal Investments LLC |
| <0.01% | <0.01% | #31 | $51.0万 | 4.4万股 | $45.7万 | 6.6万股 | -2.2万股-32.83% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #37 | $40.8万 | 3.6万股 | $0 | 0股 | +3.6万股 | 新买入 |
| Ikarian Capital, LLC |
| 0.04% | 0.02% | #23 | $39.0万 | 3.4万股 | $23.5万 | 3.4万股 | 00.00% | 持仓不变 |
| Virtus Investment Advisers, LLC |
| 0.08% | — | #17 | $36.5万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| ACT CAPITAL MANAGEMENT, LLC |
| 0.2% | — | #14 | $31.1万 | 2.7万股 | $0 | 0股 | +2.7万股 | 新买入 |
| Stonepine Capital Management, LLC |
| 0.04% | — | #22 | $27.9万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| Verition基金管理Verition Fund Management LLC |
| <0.01% | — | #34 | $20.2万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| SmartHarvest Portfolios, LLC |
| 0.05% | 0.05% | #19 | $16.6万 | 1.4万股 | $11.3万 | 1.6万股 | -1,926股-11.77% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $16.3万 | 1.4万股 | $7.7万 | 1.1万股 | +3,041股+27.32% | 加仓 |
| 对跖点合伙人ANTIPODES PARTNERS Ltd |
| <0.01% | <0.01% | #33 | $1.9万 | 1,642股 | $1.4万 | 2,051股 | -409股-19.94% | 减仓 |
| 未来资产环球投资Mirae Asset Global Investments Co., Ltd. |
| <0.01% | — | #39 | $6,636 | 577股 | $0 | 0股 | +577股 | 新买入 |
| BESSEMER GROUP INC |
| <0.01% | <0.01% | #41 | $1,047 | 91股 | $1,000 | 91股 | 00.00% | 持仓不变 |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #38 | $80 | 7股 | $0 | 0股 | +7股 | 新买入 |
