| Cormorant Asset Management, LP |
| 6.92% | 8.04% | #2 | $1.36亿 | 1,787.9万股 | $1.60亿 | 1,787.9万股 | 00.00% | 持仓不变 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.39% | 0.52% | #12 | $3,722.7万 | 488.5万股 | $4,372.5万 | 488.5万股 | 00.00% | 持仓不变 |
| Alphabet公司Alphabet Inc. |
| 0.59% | 0.63% | #7 | $2,526.7万 | 282.3万股 | $2,526.7万 | 282.3万股 | 00.00% | 持仓不变 |
| Omega Fund Management, LLC |
| 13.5% | 18.05% | #1 | $2,506.7万 | 329.0万股 | $2,944.2万 | 329.0万股 | 00.00% | 持仓不变 |
| EcoR1 Capital, LLC |
| 1.05% | 1.07% | #5 | $2,151.2万 | 282.3万股 | $2,526.7万 | 282.3万股 | 00.00% | 持仓不变 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #27 | $2,125.4万 | 278.9万股 | $2,522.4万 | 281.8万股 | -2.9万股-1.03% | 减仓 |
| Enavate Sciences GP, LLC |
| 5.8% | 6.69% | #3 | $2,001.7万 | 262.7万股 | $2,351.1万 | 262.7万股 | 00.00% | 持仓不变 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #30 | $1,994.8万 | 261.8万股 | $2,263.2万 | 252.9万股 | +8.9万股+3.52% | 加仓 |
| Novo Holdings A/S |
| 1% | 1.59% | #6 | $1,714.5万 | 225.0万股 | $1,956.4万 | 218.6万股 | +6.4万股+2.93% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #44 | $1,641.4万 | 215.4万股 | $1,869.0万 | 208.8万股 | +6.6万股+3.15% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $1,528.3万 | 200.6万股 | $481.9万 | 53.8万股 | +146.7万股+272.49% | 加仓 |
| Laurion 资本管理Laurion Capital Management LP |
| 0.39% | 0.75% | #11 | $1,526.1万 | 200.3万股 | $1,720.8万 | 192.3万股 | +8.0万股+4.16% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.16% | 0.21% | #14 | $1,344.2万 | 176.4万股 | $1,188.6万 | 132.8万股 | +43.6万股+32.83% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #45 | $789.9万 | 103.7万股 | $202.5万 | 22.6万股 | +81.0万股+358.10% | 加仓 |
| Aisling Capital Management LP |
| 1.64% | 1.91% | #4 | $775.7万 | 101.8万股 | $911.1万 | 101.8万股 | 00.00% | 持仓不变 |
| Opaleye Management Inc. |
| 0.48% | 0.06% | #8 | $533.4万 | 70.0万股 | $47.7万 | 5.3万股 | +64.7万股+1,213.76% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #43 | $474.5万 | 62.2万股 | $518.7万 | 57.9万股 | +4.3万股+7.44% | 加仓 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.15% | 0.1% | #15 | $425.6万 | 55.9万股 | $206.8万 | 23.1万股 | +32.7万股+141.74% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.46% | — | #9 | $351.3万 | 46.1万股 | $0 | 0股 | +46.1万股 | 新买入 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | 0.01% | #24 | $304.8万 | 40.0万股 | $358.0万 | 40.0万股 | 00.00% | 持仓不变 |
| Royce联营ROYCE & ASSOCIATES LP |
| 0.02% | 0.06% | #20 | $293.3万 | 38.5万股 | $569.7万 | 63.7万股 | -25.2万股-39.52% | 减仓 |
| Catalio Capital Management, LP |
| 0.46% | — | #10 | $242.6万 | 31.8万股 | $0 | 0股 | +31.8万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #46 | $228.6万 | 30.0万股 | $392.0万 | 43.8万股 | -13.8万股-31.49% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #35 | $222.1万 | 29.2万股 | $227.6万 | 25.4万股 | +3.7万股+14.62% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #40 | $218.3万 | 28.7万股 | $260.3万 | 29.1万股 | -4,288股-1.47% | 减仓 |
| Casdin Capital, LLC |
| 0.11% | 0.19% | #17 | $215.1万 | 28.2万股 | $252.7万 | 28.2万股 | 00.00% | 持仓不变 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | 0.01% | #28 | $208.4万 | 27.4万股 | $287.2万 | 32.1万股 | -4.7万股-14.75% | 减仓 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #31 | $187.2万 | 24.4万股 | $216.3万 | 24.9万股 | -4,720股-1.89% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #53 | $183.3万 | 24.1万股 | $215.1万 | 24.0万股 | +287股+0.12% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #33 | $145.7万 | 19.1万股 | $81.3万 | 9.1万股 | +10.0万股+110.48% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #48 | $142.1万 | 18.6万股 | $91.5万 | 10.2万股 | +8.4万股+82.36% | 加仓 |
| Sio Capital Management, LLC |
| 0.16% | 0.17% | #13 | $99.5万 | 13.1万股 | $116.9万 | 13.1万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #52 | $87.4万 | 11.5万股 | $45.2万 | 5.0万股 | +6.4万股+127.26% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #42 | $80.4万 | 10.5万股 | $238.0万 | 26.6万股 | -16.0万股-60.34% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #54 | $77.8万 | 10.2万股 | $150.0万 | 16.8万股 | -6.5万股-39.08% | 减仓 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.01% | 0.02% | #22 | $76.2万 | 10.0万股 | $89.5万 | 10.0万股 | 00.00% | 持仓不变 |
| Tidal投资Tidal Investments LLC |
| <0.01% | <0.01% | #32 | $71.1万 | 9.3万股 | $73.5万 | 8.2万股 | +1.1万股+13.59% | 加仓 |
| TEMA ETFS LLC |
| 0.02% | 0.05% | #21 | $71.1万 | 9.3万股 | $73.5万 | 8.2万股 | +1.1万股+13.59% | 加仓 |
| Brevan Howard资本管理Brevan Howard Capital Management LP |
| <0.01% | <0.01% | #25 | $69.1万 | 8.9万股 | $12.8万 | 1.4万股 | +7.5万股+523.91% | 加仓 |
| Palumbo Wealth Management LLC |
| 0.14% | — | #16 | $65.2万 | 8.6万股 | $0 | 0股 | +8.6万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #58 | $58.8万 | 7.7万股 | $0 | 0股 | +7.7万股 | 新买入 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | — | #26 | $47.2万 | 6.2万股 | $0 | 0股 | +6.2万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #34 | $44.7万 | 5.9万股 | $91.2万 | 10.2万股 | -4.3万股-42.49% | 减仓 |
| Avidity Partners Management LP |
| 0.05% | 0.08% | #19 | $33.4万 | 4.4万股 | $39.2万 | 4.4万股 | 00.00% | 持仓不变 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #41 | $32.6万 | 4.3万股 | $51.5万 | 5.8万股 | -1.5万股-25.78% | 减仓 |
| Virtus Investment Advisers, LLC |
| 0.07% | — | #18 | $32.2万 | 4.2万股 | $0 | 0股 | +4.2万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #49 | $21.3万 | 2.8万股 | $31.9万 | 3.6万股 | -7,708股-21.60% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #50 | $20.2万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| Rafferty资产管理Rafferty Asset Management, LLC |
| <0.01% | — | #36 | $17.2万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | — | #56 | $15.1万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
