| MAK CAPITAL ONE LLC |
| 7.54% | 6.84% | #2 | $5,379.4万 | 3,362.1万股 | $4,639.8万 | 3,362.1万股 | 00.00% | 持仓不变 |
| 黑石集团Blackstone Inc. |
| 0.1% | 0.11% | #10 | $3,277.7万 | 2,048.6万股 | $2,827.0万 | 2,048.6万股 | 00.00% | 持仓不变 |
| Syncona Portfolio Ltd |
| 100% | 89.34% | #1 | $2,662.5万 | 1,664.1万股 | $2,296.4万 | 1,664.1万股 | 00.00% | 持仓不变 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.29% | 0.39% | #4 | $2,400.0万 | 1,500.0万股 | $2,180.4万 | 1,580.0万股 | -80.0万股-5.06% | 减仓 |
| Tetragon Partners GP Ltd |
| 2.39% | 2.55% | #3 | $1,520.0万 | 950.0万股 | $1,311.0万 | 950.0万股 | 00.00% | 持仓不变 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | 0.01% | #18 | $1,292.5万 | 783.3万股 | $1,205.1万 | 948.9万股 | -165.6万股-17.45% | 减仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.15% | 0.16% | #6 | $711.7万 | 444.8万股 | $613.8万 | 444.8万股 | 00.00% | 持仓不变 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.01% | — | #22 | $537.8万 | 336.1万股 | $0 | 0股 | +336.1万股 | 新买入 |
| Laurion 资本管理Laurion Capital Management LP |
| 0.14% | 0.2% | #8 | $530.7万 | 331.7万股 | $457.7万 | 331.7万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #24 | $317.6万 | 198.5万股 | $317.3万 | 229.9万股 | -31.5万股-13.69% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #51 | $256.8万 | 160.5万股 | $254.6万 | 184.5万股 | -24.0万股-12.99% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $256.6万 | 160.3万股 | $204.3万 | 148.1万股 | +12.3万股+8.29% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #40 | $242.7万 | 151.7万股 | $180.2万 | 130.6万股 | +21.1万股+16.18% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #57 | $201.7万 | 126.1万股 | $197.8万 | 121.4万股 | +4.7万股+3.88% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $196.0万 | 122.5万股 | $28.3万 | 20.5万股 | +102.0万股+498.27% | 加仓 |
| Cetera投资顾问Cetera Investment Advisers |
| <0.01% | <0.01% | #33 | $185.2万 | 115.7万股 | $155.8万 | 112.9万股 | +2.8万股+2.50% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #31 | $155.6万 | 97.3万股 | $134.1万 | 97.2万股 | +1,057股+0.11% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #60 | $150.7万 | 91.3万股 | $118.8万 | 93.5万股 | -2.2万股-2.37% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $128.9万 | 80.6万股 | $80.8万 | 58.6万股 | +22.0万股+37.55% | 加仓 |
| Alphabet公司Alphabet Inc. |
| 0.02% | 0.02% | #14 | $96.4万 | 69.8万股 | $96.4万 | 69.8万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #63 | $81.8万 | 51.1万股 | $57.2万 | 41.4万股 | +9.7万股+23.36% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.02% | 0.02% | #15 | $72.2万 | 45.1万股 | $60.7万 | 44.0万股 | +1.1万股+2.54% | 加仓 |
| Privium Fund Management B.V. |
| 0.11% | 0.1% | #9 | $58.1万 | 36.3万股 | $50.2万 | 36.3万股 | 00.00% | 持仓不变 |
| EDENTREE ASSET MANAGEMENT Ltd |
| 0.15% | 0.12% | #7 | $47.7万 | 30.0万股 | $41.4万 | 30.0万股 | 00.00% | 持仓不变 |
| XTX资本XTX Topco Ltd |
| 0.01% | <0.01% | #20 | $46.0万 | 28.7万股 | $7.8万 | 5.6万股 | +23.1万股+409.63% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #66 | $34.0万 | 21.3万股 | $28.7万 | 20.8万股 | +4,736股+2.28% | 加仓 |
| 奥地利Erste资产管理Erste Asset Management GmbH |
| <0.01% | <0.01% | #29 | $32.2万 | 19.5万股 | $24.8万 | 19.5万股 | 00.00% | 持仓不变 |
| DAFNA Capital Management LLC |
| 0.05% | 0.06% | #11 | $28.7万 | 17.9万股 | $24.7万 | 17.9万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #73 | $28.4万 | 17.7万股 | $61.1万 | 44.3万股 | -26.6万股-59.99% | 减仓 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.19% | 0.19% | #5 | $24.0万 | 15.0万股 | $20.7万 | 15.0万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #77 | $19.8万 | 12.4万股 | $15.3万 | 11.1万股 | +1.3万股+12.08% | 加仓 |
| Clearstead顾问Clearstead Advisors, LLC |
| <0.01% | <0.01% | #32 | $19.4万 | 12.1万股 | $16.7万 | 12.1万股 | 00.00% | 持仓不变 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | <0.01% | #34 | $18.4万 | 11.5万股 | $7.6万 | 5.5万股 | +6.0万股+109.90% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #75 | $18.2万 | 11.4万股 | $16.1万 | 11.6万股 | -2,857股-2.45% | 减仓 |
| Leonteq Securities AG |
| 0.01% | 0.01% | #21 | $16.0万 | 10.0万股 | $13.8万 | 10.0万股 | 00.00% | 持仓不变 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #56 | $15.1万 | 9.5万股 | $3.7万 | 2.7万股 | +6.8万股+254.75% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #45 | $14.3万 | 8.9万股 | $0 | 0股 | +8.9万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #80 | $13.5万 | 8.4万股 | $11.5万 | 8.4万股 | +869股+1.04% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #54 | $11.4万 | 7.1万股 | $58.9万 | 42.7万股 | -35.6万股-83.32% | 减仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #62 | $11.3万 | 7.1万股 | $3.3万 | 2.4万股 | +4.7万股+199.90% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #78 | $10.6万 | 6.6万股 | $7.3万 | 5.3万股 | +1.3万股+25.01% | 加仓 |
| SmartHarvest Portfolios, LLC |
| 0.03% | 0.03% | #12 | $10.2万 | 6.4万股 | $8.2万 | 5.9万股 | +4,417股+7.46% | 加仓 |
| HighPoint Advisor 集团HighPoint Advisor Group LLC |
| <0.01% | <0.01% | #27 | $9.1万 | 5.7万股 | $9.4万 | 4.7万股 | +1.0万股+21.28% | 加仓 |
| LPL金融LPL Financial LLC |
| <0.01% | <0.01% | #76 | $6.8万 | 4.3万股 | $5.2万 | 3.8万股 | +5,000股+13.29% | 加仓 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #59 | $6.3万 | 3.9万股 | $7.5万 | 5.5万股 | -1.5万股-28.07% | 减仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #69 | $6.2万 | 3.9万股 | $4.8万 | 3.5万股 | +3,813股+10.91% | 加仓 |
| R Squared Ltd |
| 0.03% | 0.03% | #13 | $5.8万 | 3.6万股 | $5.5万 | 4.0万股 | -3,149股-7.96% | 减仓 |
| China Universal Asset Management Co., Ltd. |
| <0.01% | <0.01% | #28 | $5.1万 | 3.2万股 | $4.9万 | 3.6万股 | -3,672股-10.32% | 减仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $4.5万 | 2.8万股 | $3.8万 | 2.8万股 | +532股+1.93% | 加仓 |
| Rathbones集团Rathbones Group PLC |
| <0.01% | <0.01% | #50 | $4.5万 | 2.8万股 | $3.9万 | 2.8万股 | 00.00% | 持仓不变 |
