| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.06% | 0.04% | #18 | $9,322.2万 | 1,343.3万股 | $6,343.6万 | 986.6万股 | +356.7万股+36.16% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.08% | 0.05% | #16 | $5,636.8万 | 812.2万股 | $2,986.7万 | 464.5万股 | +347.7万股+74.86% | 加仓 |
| Redmile Group, LLC |
| 3.21% | 2.36% | #4 | $4,783.1万 | 689.2万股 | $3,562.0万 | 554.0万股 | +135.2万股+24.41% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.83% | 0.8% | #6 | $4,376.5万 | 630.6万股 | $4,054.8万 | 630.6万股 | 00.00% | 持仓不变 |
| Prosight Management, LP |
| 7.12% | 5.28% | #2 | $4,134.8万 | 595.8万股 | $3,217.9万 | 500.4万股 | +95.3万股+19.05% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #63 | $2,731.5万 | 393.6万股 | $328.4万 | 51.1万股 | +342.5万股+670.51% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.57% | — | #7 | $2,602.5万 | 375.0万股 | $0 | 0股 | +375.0万股 | 新买入 |
| NEXTBio Capital Management LP |
| 11.9% | 9.4% | #1 | $2,586.8万 | 372.7万股 | $2,025.4万 | 315.0万股 | +57.7万股+18.33% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.37% | — | #11 | $2,572.5万 | 370.7万股 | $0 | 0股 | +370.7万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $2,226.3万 | 320.8万股 | $1,464.2万 | 227.7万股 | +93.1万股+40.87% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #42 | $1,832.9万 | 264.1万股 | $1,146.4万 | 178.3万股 | +85.8万股+48.14% | 加仓 |
| 巅峰联合PINNACLE ASSOCIATES LTD |
| 0.14% | 0.11% | #13 | $1,298.8万 | 187.1万股 | $879.8万 | 136.8万股 | +50.3万股+36.78% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #40 | $1,226.9万 | 176.8万股 | $0 | 0股 | +176.8万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #56 | $1,100.1万 | 158.5万股 | $415.4万 | 64.6万股 | +93.9万股+145.43% | 加仓 |
| CLARK ESTATES INC/NY |
| 2.29% | 2.28% | #5 | $992.5万 | 143.0万股 | $948.8万 | 147.6万股 | -4.5万股-3.08% | 减仓 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | 0.01% | #27 | $975.7万 | 140.6万股 | $745.4万 | 115.9万股 | +24.7万股+21.27% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #28 | $812.5万 | 117.1万股 | $663.0万 | 103.1万股 | +14.0万股+13.55% | 加仓 |
| 683 Capital Management, LLC |
| 0.39% | 0.27% | #9 | $803.1万 | 115.7万股 | $514.4万 | 80.0万股 | +35.7万股+44.65% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #71 | $712.3万 | 102.6万股 | $169.6万 | 26.4万股 | +76.3万股+289.13% | 加仓 |
| Boxer Capital Management, LLC |
| 0.52% | — | #8 | $694.0万 | 100.0万股 | $0 | 0股 | +100.0万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #66 | $657.2万 | 94.7万股 | $0 | 0股 | +94.7万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #31 | $516.2万 | 74.4万股 | $388.7万 | 60.5万股 | +13.9万股+23.04% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #65 | $411.8万 | 59.3万股 | $123.1万 | 19.1万股 | +40.2万股+209.92% | 加仓 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #37 | $387.9万 | 55.9万股 | $246.0万 | 38.3万股 | +17.6万股+46.05% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #67 | $370.2万 | 53.3万股 | $460.4万 | 71.6万股 | -18.2万股-25.49% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #62 | $361.1万 | 52.0万股 | $81.1万 | 12.6万股 | +39.4万股+312.75% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #54 | $321.6万 | 46.3万股 | $208.7万 | 32.5万股 | +13.9万股+42.77% | 加仓 |
| S&G Foundation |
| 0.14% | 0.15% | #14 | $302.4万 | 43.6万股 | $280.2万 | 43.6万股 | 00.00% | 持仓不变 |
| Algert全球ALGERT GLOBAL LLC |
| 0.03% | 0.03% | #22 | $292.3万 | 42.1万股 | $183.9万 | 28.6万股 | +13.5万股+47.23% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #78 | $272.5万 | 39.3万股 | $252.4万 | 39.3万股 | +96股+0.02% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #53 | $247.4万 | 35.7万股 | $125.2万 | 19.5万股 | +16.2万股+83.05% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #36 | $198.8万 | 28.6万股 | $89.6万 | 13.9万股 | +14.7万股+105.66% | 加仓 |
| Hillsdale Investment Management Inc. |
| 0.04% | 0.01% | #21 | $182.8万 | 26.3万股 | $42.1万 | 6.5万股 | +19.8万股+302.78% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $168.6万 | 24.3万股 | $117.2万 | 18.3万股 | +6.0万股+32.57% | 加仓 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #45 | $157.6万 | 22.7万股 | $91.5万 | 14.2万股 | +8.5万股+59.57% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #69 | $151.6万 | 21.9万股 | $57.7万 | 9.0万股 | +12.9万股+143.39% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.01% | — | #32 | $138.8万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $134.6万 | 19.4万股 | $491.1万 | 76.4万股 | -57.0万股-74.60% | 减仓 |
| West Tower Group, LLC |
| 3.73% | — | #3 | $133.0万 | 19.2万股 | $0 | 0股 | +19.2万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #73 | $131.8万 | 19.0万股 | $26.3万 | 4.1万股 | +14.9万股+364.52% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #51 | $129.0万 | 18.6万股 | $203.2万 | 31.6万股 | -13.0万股-41.16% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #82 | $126.1万 | 18.2万股 | $4.0万 | 1.7万股 | +16.5万股+991.30% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #72 | $108.0万 | 15.6万股 | $100.1万 | 15.6万股 | 00.00% | 持仓不变 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.02% | #30 | $65.1万 | 9.4万股 | $91.6万 | 14.2万股 | -4.9万股-34.19% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | <0.01% | #35 | $61.6万 | 8.9万股 | $15.9万 | 2.5万股 | +6.4万股+259.72% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.08% | 0.29% | #17 | $60.0万 | 8.6万股 | $180.5万 | 28.1万股 | -19.4万股-69.21% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #75 | $56.5万 | 8.1万股 | $0 | 0股 | +8.1万股 | 新买入 |
| Pathstone控股Pathstone Holdings, LLC |
| <0.01% | <0.01% | #44 | $51.3万 | 7.4万股 | $47.6万 | 7.4万股 | 00.00% | 持仓不变 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #57 | $49.7万 | 7.2万股 | $20.0万 | 3.1万股 | +4.0万股+129.60% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #64 | $49.6万 | 7.1万股 | $0 | 0股 | +7.1万股 | 新买入 |
