| Federated HermesFEDERATED HERMES, INC. |
| 0.06% | 0.07% | #15 | $4,484.8万 | 211.1万股 | $4,572.7万 | 176.6万股 | +34.5万股+19.54% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.63% | 0.61% | #7 | $3,352.6万 | 157.8万股 | $3,100.1万 | 119.7万股 | +38.1万股+31.81% | 加仓 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.1% | 0.14% | #13 | $3,059.4万 | 144.0万股 | $3,299.6万 | 127.4万股 | +16.6万股+13.01% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #23 | $2,920.5万 | 137.3万股 | $0 | 0股 | +137.3万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #45 | $2,598.6万 | 122.3万股 | $170.7万 | 6.6万股 | +115.7万股+1,755.04% | 加仓 |
| Affinity Asset Advisors, LLC |
| 1.1% | 1.35% | #4 | $2,434.0万 | 114.5万股 | $2,620.8万 | 101.2万股 | +13.4万股+13.19% | 加仓 |
| MPM BioImpact LLC |
| 1.28% | 2% | #3 | $2,098.3万 | 98.7万股 | $2,591.8万 | 100.1万股 | -1.3万股-1.32% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.47% | — | #9 | $1,955.0万 | 92.0万股 | $0 | 0股 | +92.0万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #44 | $1,831.2万 | 86.2万股 | $1,377.1万 | 53.2万股 | +33.0万股+62.07% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.05% | 0.03% | #17 | $1,514.6万 | 71.3万股 | $859.8万 | 33.2万股 | +38.1万股+114.69% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.04% | #21 | $1,487.5万 | 70.0万股 | $2,460.5万 | 95.0万股 | -25.0万股-26.32% | 减仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.57% | 0.19% | #8 | $1,434.4万 | 67.5万股 | $388.5万 | 15.0万股 | +52.5万股+350.00% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $1,392.3万 | 65.5万股 | $875.4万 | 33.8万股 | +31.7万股+93.86% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #31 | $1,163.3万 | 54.7万股 | $604.4万 | 23.3万股 | +31.4万股+134.57% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #42 | $1,068.5万 | 50.3万股 | $882.4万 | 34.1万股 | +16.2万股+47.59% | 加仓 |
| Cable Car 资本Cable Car Capital, LP |
| 3.37% | 3.44% | #1 | $1,036.0万 | 40.0万股 | $1,036.0万 | 40.0万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #41 | $1,006.0万 | 47.3万股 | $325.1万 | 12.5万股 | +34.8万股+277.29% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #29 | $890.1万 | 41.9万股 | $289.5万 | 11.2万股 | +30.7万股+274.72% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #51 | $698.1万 | 32.9万股 | $142.0万 | 5.5万股 | +27.4万股+499.26% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.03% | — | #19 | $643.5万 | 30.3万股 | $0 | 0股 | +30.3万股 | 新买入 |
| Boxer Capital Management, LLC |
| 0.44% | — | #10 | $583.3万 | 27.5万股 | $0 | 0股 | +27.5万股 | 新买入 |
| Trails Edge Capital Partners, LP |
| 0.92% | — | #5 | $580.5万 | 27.3万股 | $0 | 0股 | +27.3万股 | 新买入 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.69% | 0.76% | #6 | $530.6万 | 25.0万股 | $479.1万 | 18.5万股 | +6.5万股+34.98% | 加仓 |
| Squadron Capital Management LLC |
| 1.48% | — | #2 | $478.1万 | 22.5万股 | $0 | 0股 | +22.5万股 | 新买入 |
| AWM Investment Company, Inc. |
| 0.41% | 0.57% | #11 | $472.8万 | 22.3万股 | $518.0万 | 20.0万股 | +2.3万股+11.25% | 加仓 |
| LORD, ABBETT & CO. LLC |
| 0.01% | 0.01% | #22 | $447.2万 | 21.0万股 | $296.9万 | 11.5万股 | +9.6万股+83.58% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #43 | $349.7万 | 16.5万股 | $53.0万 | 2.0万股 | +14.4万股+704.68% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #46 | $320.6万 | 15.1万股 | $61.4万 | 2.4万股 | +12.7万股+536.33% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #39 | $289.4万 | 13.6万股 | $186.7万 | 7.2万股 | +6.4万股+88.88% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #61 | $284.3万 | 13.4万股 | $0 | 0股 | +13.4万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #53 | $239.5万 | 11.3万股 | $494.2万 | 19.1万股 | -7.8万股-40.93% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #40 | $230.2万 | 10.8万股 | $0 | 0股 | +10.8万股 | 新买入 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #33 | $149.6万 | 7.0万股 | $237.7万 | 9.2万股 | -2.1万股-23.28% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #60 | $100.0万 | 4.7万股 | $0 | 0股 | +4.7万股 | 新买入 |
| J. Goldman & Co LP |
| 0.03% | 0.04% | #20 | $98.1万 | 4.6万股 | $140.3万 | 5.4万股 | -7,992股-14.75% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $95.6万 | 4.5万股 | $2,265 | 151股 | +4.5万股+29,705.96% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #56 | $93.8万 | 4.4万股 | $76.4万 | 2.9万股 | +1.5万股+49.73% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #58 | $87.0万 | 4.1万股 | $0 | 0股 | +4.1万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $85.3万 | 4.0万股 | $138.5万 | 5.3万股 | -1.3万股-24.90% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #36 | $82.7万 | 3.9万股 | $48.5万 | 1.9万股 | +2.0万股+107.82% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #70 | $71.3万 | 3.4万股 | $56.0万 | 2.2万股 | +1.2万股+55.36% | 加仓 |
| MANGROVE PARTNERS IM, LLC |
| 0.05% | 0.05% | #18 | $70.9万 | 3.3万股 | $66.6万 | 2.6万股 | +7,640股+29.72% | 加仓 |
| Envestnet资产管理ENVESTNET ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #57 | $64.0万 | 3.0万股 | $74.3万 | 2.9万股 | +1,411股+4.92% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | — | #25 | $63.6万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| <0.01% | 0.01% | #27 | $53.5万 | 2.5万股 | $190.8万 | 7.4万股 | -4.8万股-65.83% | 减仓 |
| Weil Company, Inc. |
| 0.09% | 0.14% | #14 | $52.6万 | 2.5万股 | $64.1万 | 2.5万股 | 00.00% | 持仓不变 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #47 | $47.1万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| Ikarian Capital, LLC |
| 0.05% | 0.25% | #16 | $44.6万 | 2.1万股 | $308.1万 | 11.9万股 | -9.8万股-82.37% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #72 | $44.2万 | 2.1万股 | $150.0万 | 5.8万股 | -3.7万股-64.09% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #62 | $41.0万 | 1.9万股 | $0 | 0股 | +1.9万股 | 新买入 |
