| 贝莱德BlackRock, Inc. |
| 0.04% | 0.02% | #247 | $25.65亿 | 1,369.6万股 | $10.90亿 | 1,121.3万股 | +248.3万股+22.15% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 11.71% | 7.54% | #13 | $25.38亿 | 1,355.1万股 | $13.23亿 | 1,360.5万股 | -5.4万股-0.40% | 减仓 |
| 富达投资FMR LLC |
| 0.1% | 0.04% | #154 | $22.85亿 | 1,220.0万股 | $8.23亿 | 846.4万股 | +373.6万股+44.14% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 10.74% | 5.34% | #14 | $21.43亿 | 1,144.3万股 | $9.29亿 | 955.5万股 | +188.8万股+19.76% | 加仓 |
| Darwin Global Management, Ltd. |
| 54.45% | 5.44% | #3 | $20.48亿 | 1,063.0万股 | $2.05亿 | 221.1万股 | +841.9万股+380.77% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.82% | — | #72 | $20.10亿 | 1,073.6万股 | $0 | 0股 | +1,073.6万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.04% | 0.02% | #253 | $17.02亿 | 908.9万股 | $8.13亿 | 836.2万股 | +72.6万股+8.69% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.07% | 0.04% | #181 | $15.53亿 | 829.5万股 | $7.30亿 | 750.3万股 | +79.2万股+10.56% | 加仓 |
| Nextech Invest Ltd. |
| 67.81% | 52.02% | #1 | $14.24亿 | 760.1万股 | $7.39亿 | 760.1万股 | 00.00% | 持仓不变 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 22.31% | 13.23% | #6 | $11.91亿 | 636.1万股 | $6.47亿 | 665.6万股 | -29.4万股-4.42% | 减仓 |
| 瑞银集团UBS Group AG |
| 0.13% | 0.06% | #142 | $10.22亿 | 545.5万股 | $4.27亿 | 439.4万股 | +106.1万股+24.15% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.03% | 0.01% | #300 | $9.17亿 | 489.7万股 | $4.28亿 | 440.3万股 | +49.4万股+11.23% | 加仓 |
| 资本世界投资者Capital World Investors |
| 0.09% | — | #164 | $7.51亿 | 400.8万股 | $0 | 0股 | +400.8万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.04% | 0.02% | #244 | $7.37亿 | 394.3万股 | $3.24亿 | 333.8万股 | +60.5万股+18.11% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.12% | 0.11% | #144 | $7.20亿 | 384.3万股 | $5.86亿 | 602.8万股 | -218.4万股-36.24% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.04% | <0.01% | #260 | $6.37亿 | 329.8万股 | $2,794.2万 | 30.1万股 | +299.7万股+994.27% | 加仓 |
| BVF INC/IL |
| 14.2% | 8.85% | #11 | $5.55亿 | 296.5万股 | $2.78亿 | 285.7万股 | +10.8万股+3.79% | 加仓 |
| Casdin Capital, LLC |
| 24.16% | 18.98% | #5 | $4.83亿 | 257.7万股 | $2.51亿 | 257.7万股 | 00.00% | 持仓不变 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 4.67% | 2.64% | #29 | $4.48亿 | 239.2万股 | $2.23亿 | 229.7万股 | +9.5万股+4.14% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.04% | 0.04% | #226 | $4.48亿 | 239.0万股 | $3.14亿 | 323.2万股 | -84.2万股-26.05% | 减仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 3.86% | 2.24% | #32 | $4.30亿 | 229.7万股 | $2.28亿 | 234.4万股 | -4.7万股-2.02% | 减仓 |
| Caligan Partners LP |
| 19.5% | 12.18% | #9 | $4.15亿 | 221.4万股 | $1.83亿 | 188.2万股 | +33.2万股+17.64% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.04% | 0.01% | #239 | $4.04亿 | 215.7万股 | $4,962.9万 | 140.4万股 | +75.4万股+53.72% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.03% | 0.02% | #261 | $3.99亿 | 213.3万股 | $2.13亿 | 218.6万股 | -5.2万股-2.40% | 减仓 |
| 近水资本市场Nearwater Capital Markets, Ltd |
| 6.77% | 1.56% | #22 | $3.93亿 | 209.7万股 | $6,593.6万 | 67.8万股 | +141.9万股+209.29% | 加仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.12% | — | #145 | $3.77亿 | 201.2万股 | $0 | 0股 | +201.2万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 1.16% | 0.92% | #66 | $3.75亿 | 200.3万股 | $2.44亿 | 250.7万股 | -50.4万股-20.10% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.05% | 0.03% | #217 | $3.59亿 | 191.7万股 | $1.69亿 | 173.5万股 | +18.2万股+10.46% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.03% | 0.02% | #299 | $3.51亿 | 187.6万股 | $2.17亿 | 222.9万股 | -35.3万股-15.85% | 减仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 13.32% | 12.79% | #12 | $3.37亿 | 180.0万股 | $2.67亿 | 275.0万股 | -95.0万股-34.55% | 减仓 |
| Alphabet公司Alphabet Inc. |
| 7.47% | 7.97% | #19 | $3.20亿 | 329.3万股 | $3.20亿 | 329.3万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.06% | 0.02% | #195 | $2.79亿 | 148.8万股 | $1.10亿 | 113.4万股 | +35.5万股+31.30% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.57% | 0.58% | #83 | $2.55亿 | 135.9万股 | $2.40亿 | 246.9万股 | -110.9万股-44.94% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.08% | 0.01% | #166 | $2.43亿 | 129.5万股 | $1,135.7万 | 11.7万股 | +117.9万股+1,009.24% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.05% | 0.03% | #201 | $2.42亿 | 129.1万股 | $1.10亿 | 113.3万股 | +15.8万股+13.93% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.03% | 0.02% | #306 | $2.27亿 | 121.2万股 | $9,768.3万 | 100.4万股 | +20.8万股+20.70% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.02% | 0.01% | #314 | $2.09亿 | 111.7万股 | $9,280.1万 | 95.4万股 | +16.3万股+17.07% | 加仓 |
| Rock Springs Capital Management LP |
| 10.1% | 6.93% | #15 | $2.07亿 | 110.5万股 | $1.18亿 | 120.9万股 | -10.4万股-8.62% | 减仓 |
| 加拿大国家银行NATIONAL BANK OF CANADA /FI/ |
| 0.18% | 0.17% | #122 | $2.05亿 | 109.6万股 | $1.70亿 | 174.9万股 | -65.3万股-37.33% | 减仓 |
| Bellevue 集团Bellevue Group AG |
| 4.13% | 3.57% | #31 | $1.96亿 | 104.8万股 | $1.50亿 | 154.4万股 | -49.6万股-32.14% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.04% | 0.04% | #242 | $1.95亿 | 104.0万股 | $1.54亿 | 158.0万股 | -54.0万股-34.19% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.18% | 0.06% | #120 | $1.91亿 | 101.5万股 | $5,359.2万 | 55.8万股 | +45.7万股+82.02% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #391 | $1.84亿 | 98.4万股 | $5,972.7万 | 61.4万股 | +37.0万股+60.21% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.03% | 0.01% | #279 | $1.71亿 | 91.2万股 | $4,868.3万 | 50.1万股 | +41.2万股+82.25% | 加仓 |
| Siren, L.L.C. |
| 3.41% | 3% | #38 | $1.69亿 | 90.0万股 | $1.08亿 | 111.1万股 | -21.1万股-18.99% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| 0.05% | 0.01% | #215 | $1.66亿 | 88.8万股 | $4,529.5万 | 46.6万股 | +42.2万股+90.66% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.77% | 0.88% | #76 | $1.64亿 | 87.7万股 | $1.51亿 | 155.0万股 | -67.3万股-43.42% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #428 | $1.57亿 | 83.8万股 | $6,699.8万 | 143.5万股 | -59.6万股-41.57% | 减仓 |
| LORD, ABBETT & CO. LLC |
| 0.42% | 0.04% | #94 | $1.48亿 | 78.9万股 | $1,305.4万 | 13.4万股 | +65.5万股+487.96% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.03% | 0.02% | #307 | $1.43亿 | 76.3万股 | $8,207.2万 | 84.5万股 | -8.1万股-9.61% | 减仓 |
