| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.65% | 0.35% | #9 | $4,332.1万 | 130.5万股 | $1,781.8万 | 71.5万股 | +59.0万股+82.42% | 加仓 |
| BVF INC/IL |
| 1.06% | 0.99% | #8 | $4,155.9万 | 125.2万股 | $3,118.2万 | 125.2万股 | 00.00% | 持仓不变 |
| Affinity Asset Advisors, LLC |
| 1.76% | 1.38% | #5 | $3,892.7万 | 117.2万股 | $2,664.2万 | 107.0万股 | +10.3万股+9.63% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #51 | $3,727.2万 | 112.3万股 | $579.6万 | 23.3万股 | +89.0万股+382.48% | 加仓 |
| Samsara BioCapital, LLC |
| 2.9% | 2.57% | #4 | $3,528.7万 | 106.3万股 | $2,647.6万 | 106.3万股 | 00.00% | 持仓不变 |
| Kynam Capital Management, LP |
| 1.6% | 1.34% | #7 | $2,896.9万 | 87.3万股 | $2,173.5万 | 87.3万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.47% | 0.4% | #12 | $2,469.9万 | 74.4万股 | $1,995.6万 | 80.1万股 | -5.7万股-7.14% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.02% | #23 | $2,361.1万 | 71.1万股 | $1,160.3万 | 46.6万股 | +24.5万股+52.68% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $2,304.8万 | 69.4万股 | $1,794.6万 | 72.0万股 | -2.6万股-3.64% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.26% | 0.29% | #14 | $1,943.1万 | 58.5万股 | $1,781.8万 | 71.5万股 | -13.0万股-18.18% | 减仓 |
| Velan Capital Investment Management LP |
| 10.36% | 7.99% | #1 | $1,700.4万 | 51.2万股 | $1,275.8万 | 51.2万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.05% | 0.04% | #19 | $1,520.7万 | 45.8万股 | $1,139.5万 | 45.7万股 | +588股+0.13% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.62% | 0.77% | #11 | $1,341.3万 | 40.4万股 | $1,306.4万 | 52.4万股 | -12.0万股-22.96% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #50 | $1,294.1万 | 39.0万股 | $427.2万 | 17.1万股 | +21.8万股+127.38% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #26 | $1,241.1万 | 37.4万股 | $836.3万 | 33.6万股 | +3.8万股+11.32% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $1,215.0万 | 36.6万股 | $524.1万 | 21.0万股 | +15.6万股+73.96% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #63 | $1,015.9万 | 30.6万股 | $129.8万 | 5.2万股 | +25.4万股+487.09% | 加仓 |
| Merck & Co., Inc. |
| 1.72% | 1.94% | #6 | $904.2万 | 27.2万股 | $678.4万 | 27.2万股 | 00.00% | 持仓不变 |
| ACUTA CAPITAL PARTNERS, LLC |
| 6.25% | 4.73% | #2 | $897.2万 | 27.0万股 | $671.1万 | 26.9万股 | +826股+0.31% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #40 | $812.3万 | 24.5万股 | $0 | 0股 | +24.5万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.02% | #28 | $789.6万 | 23.8万股 | $1,724.0万 | 69.2万股 | -45.4万股-65.64% | 减仓 |
| KVP Capital Advisors, LP |
| 5.52% | 4.22% | #3 | $752.2万 | 22.7万股 | $564.4万 | 22.7万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #46 | $692.3万 | 20.9万股 | $978.6万 | 39.3万股 | -18.4万股-46.93% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #32 | $669.6万 | 20.2万股 | $162.4万 | 6.5万股 | +13.7万股+209.45% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #64 | $655.9万 | 19.8万股 | $0 | 0股 | +19.8万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | 0.01% | #34 | $581.8万 | 17.5万股 | $554.6万 | 22.3万股 | -4.7万股-21.29% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #42 | $557.8万 | 16.8万股 | $0 | 0股 | +16.8万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #65 | $532.4万 | 16.0万股 | $0 | 0股 | +16.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $495.4万 | 14.9万股 | $67.7万 | 2.7万股 | +12.2万股+448.85% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #54 | $418.1万 | 12.6万股 | $82.6万 | 3.3万股 | +9.3万股+279.71% | 加仓 |
| Seven Fleet Capital Management LP |
| 0.63% | — | #10 | $379.4万 | 15.9万股 | $0 | 0股 | +15.9万股 | 新买入 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | — | #37 | $353.9万 | 10.7万股 | $0 | 0股 | +10.7万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #47 | $346.1万 | 10.4万股 | $236.2万 | 9.5万股 | +9,394股+9.91% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $338.5万 | 10.2万股 | $354.6万 | 14.2万股 | -4.0万股-28.36% | 减仓 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| <0.01% | — | #38 | $314.6万 | 9.5万股 | $0 | 0股 | +9.5万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #36 | $286.6万 | 8.6万股 | $243.7万 | 9.8万股 | -1.2万股-11.76% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #75 | $190.3万 | 5.7万股 | $42.8万 | 1.7万股 | +4.0万股+233.85% | 加仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.04% | — | #22 | $185.5万 | 5.6万股 | $0 | 0股 | +5.6万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #39 | $184.4万 | 5.6万股 | $0 | 0股 | +5.6万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| 0.02% | <0.01% | #24 | $173.2万 | 5.2万股 | $20.4万 | 8,203股 | +4.4万股+535.97% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #73 | $163.7万 | 4.9万股 | $26.3万 | 1.1万股 | +3.9万股+366.12% | 加仓 |
| Sigma Planning Corp |
| 0.04% | 0.01% | #21 | $149.5万 | 4.5万股 | $31.2万 | 1.3万股 | +3.3万股+259.58% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #72 | $137.3万 | 4.1万股 | $0 | 0股 | +4.1万股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #71 | $122.7万 | 3.7万股 | $3,462 | 139股 | +3.7万股+26,485.61% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #82 | $120.0万 | 3.6万股 | $47.0万 | 1.9万股 | +1.7万股+91.49% | 加仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| <0.01% | <0.01% | #62 | $117.2万 | 3.5万股 | $87.9万 | 3.5万股 | 00.00% | 持仓不变 |
| Elmind Capital, LP |
| 0.27% | — | #13 | $106.4万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #81 | $101.3万 | 3.1万股 | $302.7万 | 12.2万股 | -9.1万股-74.88% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #55 | $100.0万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | 0.01% | #31 | $91.8万 | 2.8万股 | $85.5万 | 3.4万股 | -6,707股-19.53% | 减仓 |
