| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 1.08% | — | #6 | $4,972.5万 | 761.5万股 | $0 | 0股 | +761.5万股 | 新买入 |
| TPG集团TPG GP A, LLC |
| 0.9% | — | #8 | $4,491.1万 | 687.8万股 | $0 | 0股 | +687.8万股 | 新买入 |
| venBio Partners LLC |
| 7.44% | — | #2 | $3,862.3万 | 591.5万股 | $0 | 0股 | +591.5万股 | 新买入 |
| Logos Global Management LP |
| 1.53% | — | #5 | $3,542.5万 | 542.5万股 | $0 | 0股 | +542.5万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #65 | $3,442.6万 | 527.2万股 | $129.2万 | 43.9万股 | +483.3万股+1,099.93% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #38 | $3,234.5万 | 495.3万股 | $1,284.5万 | 436.9万股 | +58.4万股+13.37% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 0.61% | — | #9 | $3,233.6万 | 495.2万股 | $0 | 0股 | +495.2万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $2,704.0万 | 414.1万股 | $648.2万 | 220.5万股 | +193.6万股+87.82% | 加仓 |
| Propel Bio Management, LLC |
| 13.79% | 7.17% | #1 | $2,634.2万 | 403.4万股 | $1,136.9万 | 378.6万股 | +24.8万股+6.54% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.02% | <0.01% | #28 | $2,462.0万 | 377.0万股 | $299.7万 | 101.9万股 | +275.1万股+269.90% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #62 | $1,923.4万 | 294.6万股 | $74.8万 | 25.4万股 | +269.1万股+1,057.57% | 加仓 |
| Venrock Adviser, LLC |
| 0.54% | — | #10 | $1,796.4万 | 275.1万股 | $0 | 0股 | +275.1万股 | 新买入 |
| Vivo Capital, LLC |
| 1.64% | — | #4 | $1,796.4万 | 275.1万股 | $0 | 0股 | +275.1万股 | 新买入 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #37 | $1,796.4万 | 275.1万股 | $0 | 0股 | +275.1万股 | 新买入 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.19% | — | #12 | $1,449.7万 | 222.0万股 | $0 | 0股 | +222.0万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #59 | $1,347.2万 | 206.3万股 | $183.2万 | 62.3万股 | +144.0万股+231.21% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.03% | — | #26 | $1,257.5万 | 192.6万股 | $0 | 0股 | +192.6万股 | 新买入 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.13% | 0.05% | #15 | $935.2万 | 143.2万股 | $348.2万 | 118.5万股 | +24.8万股+20.90% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #48 | $931.8万 | 142.7万股 | $0 | 0股 | +142.7万股 | 新买入 |
| Caption管理Caption Management, LLC |
| 0.04% | <0.01% | #23 | $916.3万 | 140.3万股 | $8.9万 | 3.0万股 | +137.3万股+4,556.03% | 加仓 |
| LPL金融LPL Financial LLC |
| <0.01% | <0.01% | #52 | $589.2万 | 90.2万股 | $214.2万 | 72.8万股 | +17.4万股+23.86% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $485.7万 | 74.4万股 | $66.1万 | 22.5万股 | +51.9万股+230.94% | 加仓 |
| Spruce Street Capital LP |
| 0.94% | — | #7 | $481.0万 | 73.7万股 | $0 | 0股 | +73.7万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #69 | $464.7万 | 71.2万股 | $150.2万 | 51.1万股 | +20.1万股+39.28% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #57 | $387.7万 | 59.4万股 | $93.0万 | 31.6万股 | +27.8万股+87.79% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #56 | $356.7万 | 54.6万股 | $188.7万 | 64.2万股 | -9.6万股-14.89% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #81 | $351.1万 | 53.8万股 | $0 | 0股 | +53.8万股 | 新买入 |
| KVP Capital Advisors, LP |
| 2.22% | 1.02% | #3 | $301.9万 | 46.2万股 | $135.9万 | 46.2万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #47 | $288.1万 | 44.1万股 | $173.0万 | 58.9万股 | -14.7万股-25.04% | 减仓 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #45 | $252.0万 | 38.6万股 | $36.8万 | 12.5万股 | +26.1万股+208.47% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #75 | $213.0万 | 32.6万股 | $59.6万 | 20.3万股 | +12.3万股+60.86% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #74 | $204.4万 | 31.3万股 | $95.9万 | 32.6万股 | -1.3万股-4.07% | 减仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #55 | $181.7万 | 27.8万股 | $41.9万 | 14.3万股 | +13.6万股+95.16% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #84 | $166.1万 | 25.4万股 | $51.9万 | 17.7万股 | +7.8万股+44.03% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #77 | $151.6万 | 23.2万股 | $12.6万 | 4.3万股 | +18.9万股+439.86% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.15% | — | #14 | $148.3万 | 22.7万股 | $0 | 0股 | +22.7万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #76 | $142.4万 | 21.8万股 | $0 | 0股 | +21.8万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #73 | $124.8万 | 19.1万股 | $0 | 0股 | +19.1万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #95 | $120.9万 | 18.5万股 | $20.8万 | 7.1万股 | +11.4万股+161.83% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #49 | $116.3万 | 17.8万股 | $8.2万 | 2.8万股 | +15.0万股+536.98% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #78 | $111.4万 | 17.1万股 | $30.0万 | 10.2万股 | +6.9万股+67.33% | 加仓 |
| 康托·菲茨杰拉德CANTOR FITZGERALD, L. P. |
| 0.01% | — | #35 | $79.4万 | 12.2万股 | $0 | 0股 | +12.2万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #68 | $79.2万 | 12.1万股 | $747 | 254股 | +12.1万股+47,622.44% | 加仓 |
| Shay Capital LLC |
| 0.04% | 0.05% | #24 | $60.6万 | 9.3万股 | $60.3万 | 20.5万股 | -11.2万股-54.75% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | <0.01% | #36 | $58.8万 | 9.0万股 | $5.4万 | 1.8万股 | +7.2万股+394.18% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #67 | $56.8万 | 8.7万股 | $0 | 0股 | +8.7万股 | 新买入 |
| Blue TrustBlue Trust, Inc. |
| 0.01% | <0.01% | #40 | $56.1万 | 8.6万股 | $25.3万 | 8.6万股 | 00.00% | 持仓不变 |
| Diametric Capital, LP |
| 0.06% | 0.01% | #22 | $53.0万 | 8.1万股 | $5.5万 | 1.9万股 | +6.3万股+335.25% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #83 | $50.6万 | 7.7万股 | $0 | 0股 | +7.7万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #80 | $48.4万 | 7.4万股 | $1.6万 | 5,448股 | +6.9万股+1,260.39% | 加仓 |
