| Flagship Pioneering, LLC |
| 4.02% | 5.22% | #1 | $6,185.0万 | 1,267.4万股 | $6,058.2万 | 1,267.4万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 0.73% | 0.89% | #3 | $2,850.9万 | 584.2万股 | $2,792.5万 | 584.2万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #27 | $2,784.5万 | 570.6万股 | $2,890.6万 | 604.7万股 | -34.1万股-5.64% | 减仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.22% | 0.25% | #7 | $2,144.5万 | 439.4万股 | $2,100.5万 | 439.4万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #42 | $1,281.9万 | 262.7万股 | $1,130.4万 | 236.5万股 | +26.2万股+11.08% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #21 | $1,215.1万 | 249.0万股 | $1,243.9万 | 260.2万股 | -11.2万股-4.32% | 减仓 |
| Euclidean Capital LLC |
| 1.75% | 1.92% | #2 | $768.0万 | 157.4万股 | $752.3万 | 157.4万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $729.4万 | 149.5万股 | $714.7万 | 149.5万股 | -478股-0.03% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $444.6万 | 91.1万股 | $405.5万 | 84.8万股 | +6.3万股+7.39% | 加仓 |
| Siren, L.L.C. |
| 0.07% | 0.1% | #10 | $351.7万 | 72.1万股 | $344.5万 | 72.1万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #50 | $340.4万 | 69.7万股 | $324.9万 | 68.0万股 | +1.8万股+2.60% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #34 | $272.6万 | 55.9万股 | $214.6万 | 44.9万股 | +11.0万股+24.44% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #25 | $184.4万 | 37.8万股 | $194.3万 | 40.6万股 | -2.8万股-7.01% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.01% | — | #18 | $153.0万 | 31.4万股 | $0 | 0股 | +31.4万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #43 | $151.2万 | 31.0万股 | $131.9万 | 27.6万股 | +3.4万股+12.29% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | 0.01% | #19 | $149.1万 | 30.5万股 | $145.2万 | 30.4万股 | +1,677股+0.55% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $148.6万 | 30.4万股 | $122.3万 | 25.6万股 | +4.9万股+18.95% | 加仓 |
| Birchview Capital, LP |
| 0.62% | 0.77% | #4 | $137.6万 | 28.2万股 | $134.7万 | 28.2万股 | +207股+0.07% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #38 | $129.0万 | 26.4万股 | $115.0万 | 24.1万股 | +2.4万股+9.91% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #29 | $99.2万 | 20.3万股 | $38.9万 | 8.1万股 | +12.2万股+150.12% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| <0.01% | <0.01% | #22 | $98.6万 | 20.2万股 | $86.2万 | 18.0万股 | +2.2万股+12.10% | 加仓 |
| B Group, Inc. |
| 0.46% | 0.36% | #5 | $97.6万 | 20.0万股 | $48.8万 | 10.2万股 | +9.8万股+96.08% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #24 | $85.6万 | 17.5万股 | $55.0万 | 11.5万股 | +6.0万股+52.44% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $80.2万 | 16.4万股 | $65.1万 | 13.6万股 | +2.8万股+20.68% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #52 | $77.5万 | 15.9万股 | $95.6万 | 20.0万股 | -4.1万股-20.59% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #30 | $63.6万 | 13.0万股 | $49.6万 | 10.4万股 | +2.7万股+25.64% | 加仓 |
| DAFNA Capital Management LLC |
| 0.1% | 0.12% | #8 | $54.6万 | 11.2万股 | $53.5万 | 11.2万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #57 | $53.6万 | 11.0万股 | $49.5万 | 10.4万股 | +6,256股+6.04% | 加仓 |
| SCS资本管理SCS Capital Management LLC |
| <0.01% | 0.01% | #20 | $52.2万 | 10.7万股 | $51.1万 | 10.7万股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #75 | $44.9万 | 9.2万股 | $31.1万 | 6.4万股 | +2.8万股+44.63% | 加仓 |
| Palumbo Wealth Management LLC |
| 0.09% | — | #9 | $44.8万 | 9.2万股 | $0 | 0股 | +9.2万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #17 | $43.7万 | 9.0万股 | $35.7万 | 7.5万股 | +1.5万股+20.11% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #62 | $38.7万 | 7.9万股 | $38.0万 | 8.0万股 | -204股-0.26% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #69 | $38.1万 | 7.8万股 | $8.5万 | 1.8万股 | +6.0万股+340.54% | 加仓 |
| DIADEMA PARTNERS LP |
| 0.04% | 0.07% | #13 | $32.7万 | 6.7万股 | $38.2万 | 8.0万股 | -1.3万股-16.31% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $32.3万 | 6.6万股 | $15.6万 | 3.3万股 | +3.4万股+103.44% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #55 | $31.7万 | 6.5万股 | $24.1万 | 5.0万股 | +1.5万股+29.10% | 加仓 |
| Lynx1 Capital Management LP |
| 0.06% | — | #12 | $30.1万 | 6.2万股 | $0 | 0股 | +6.2万股 | 新买入 |
| 威斯康星州投资委员会STATE OF WISCONSIN INVESTMENT BOARD |
| <0.01% | <0.01% | #33 | $28.3万 | 5.8万股 | $31.4万 | 6.6万股 | -7,551股-11.50% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $26.1万 | 5.4万股 | $14.1万 | 3.0万股 | +2.4万股+81.07% | 加仓 |
| Verdad Advisers, LP |
| 0.25% | 0.13% | #6 | $26.0万 | 5.3万股 | $11.7万 | 2.4万股 | +2.9万股+118.02% | 加仓 |
| Persistent Asset Partners Ltd |
| 0.07% | 0.08% | #11 | $22.9万 | 4.7万股 | $22.3万 | 4.7万股 | +228股+0.49% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.02% | — | #14 | $22.4万 | 4.6万股 | $0 | 0股 | +4.6万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #47 | $19.3万 | 4.0万股 | $18.9万 | 4.0万股 | +77股+0.19% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $18.9万 | 3.9万股 | $17.7万 | 3.8万股 | +1,153股+3.06% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #64 | $17.8万 | 3.7万股 | $13.1万 | 2.7万股 | +9,116股+33.24% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | <0.01% | #26 | $17.8万 | 3.6万股 | $6.6万 | 1.4万股 | +2.3万股+164.80% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #73 | $17.2万 | 3.5万股 | $7.0万 | 1.5万股 | +2.1万股+139.47% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | — | #16 | $14.4万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #65 | $14.2万 | 3.0万股 | $14.4万 | 2.7万股 | +3,100股+11.63% | 加仓 |
