| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.23% | 0.28% | #9 | $2,693.5万 | 1,301.2万股 | $2,608.9万 | 1,301.2万股 | 00.00% | 持仓不变 |
| venBio Partners LLC |
| 5.14% | 9.21% | #1 | $2,667.1万 | 1,288.5万股 | $2,583.4万 | 1,288.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #44 | $1,531.7万 | 740.0万股 | $89.8万 | 44.8万股 | +695.2万股+1,552.42% | 加仓 |
| Redmile Group, LLC |
| 1.03% | 1.06% | #6 | $1,530.2万 | 739.3万股 | $1,596.8万 | 796.4万股 | -57.2万股-7.18% | 减仓 |
| 黑石集团Blackstone Inc. |
| 0.04% | 0.05% | #16 | $1,364.9万 | 659.4万股 | $1,171.1万 | 582.7万股 | +76.7万股+13.16% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.07% | 0.08% | #12 | $1,247.2万 | 602.5万股 | $1,149.8万 | 573.5万股 | +29.1万股+5.07% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.24% | — | #5 | $1,189.2万 | 574.5万股 | $0 | 0股 | +574.5万股 | 新买入 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.28% | 0.75% | #8 | $1,170.7万 | 565.5万股 | $2,608.9万 | 1,301.2万股 | -735.6万股-56.54% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $1,029.5万 | 497.3万股 | $838.0万 | 418.0万股 | +79.4万股+18.99% | 加仓 |
| Vivo Capital, LLC |
| 0.6% | 0.53% | #7 | $659.2万 | 318.5万股 | $638.5万 | 318.5万股 | 00.00% | 持仓不变 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #22 | $635.8万 | 307.1万股 | $751.4万 | 375.7万股 | -68.6万股-18.25% | 减仓 |
| 5AM Venture Management, LLC |
| 2.2% | 1.7% | #3 | $632.9万 | 305.7万股 | $613.0万 | 305.7万股 | 00.00% | 持仓不变 |
| Almitas Capital LLC |
| 1.42% | 1.44% | #4 | $608.3万 | 293.8万股 | $636.4万 | 317.4万股 | -23.5万股-7.42% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.11% | 0.11% | #11 | $593.3万 | 286.6万股 | $574.7万 | 286.6万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $577.1万 | 278.8万股 | $99.0万 | 49.3万股 | +229.4万股+464.98% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #25 | $450.9万 | 217.8万股 | $318.4万 | 158.8万股 | +59.0万股+37.18% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $319.5万 | 154.4万股 | $398.7万 | 198.9万股 | -44.5万股-22.38% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #57 | $310.3万 | 149.9万股 | $35.3万 | 17.6万股 | +132.3万股+752.48% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $271.9万 | 131.3万股 | $220.2万 | 110.1万股 | +21.2万股+19.30% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #52 | $229.8万 | 104.5万股 | $189 | 99股 | +104.5万股+1,055,180.81% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #45 | $193.7万 | 93.6万股 | $27.5万 | 13.7万股 | +79.9万股+583.15% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | <0.01% | #28 | $167.7万 | 81.0万股 | $190.6万 | 95.1万股 | -14.0万股-14.75% | 减仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.05% | — | #14 | $155.3万 | 75.0万股 | $0 | 0股 | +75.0万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $155.1万 | 74.9万股 | $19.6万 | 9.8万股 | +65.1万股+665.45% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #41 | $153.9万 | 74.3万股 | $59.0万 | 29.4万股 | +44.9万股+152.48% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $153.7万 | 74.2万股 | $27.8万 | 13.9万股 | +60.4万股+435.62% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #30 | $125.0万 | 60.4万股 | $146.9万 | 73.3万股 | -12.9万股-17.58% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.05% | — | #15 | $110.5万 | 53.4万股 | $0 | 0股 | +53.4万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #54 | $95.8万 | 46.3万股 | $183.4万 | 91.5万股 | -45.2万股-49.39% | 减仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.05% | 0.01% | #13 | $85.6万 | 41.4万股 | $13.8万 | 6.9万股 | +34.5万股+499.45% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #63 | $49.9万 | 24.1万股 | $0 | 0股 | +24.1万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #59 | $49.4万 | 23.8万股 | $0 | 0股 | +23.8万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #20 | $46.8万 | 22.6万股 | $15.3万 | 7.6万股 | +15.0万股+197.18% | 加仓 |
| Atom Investors LP |
| 0.04% | — | #17 | $45.4万 | 21.9万股 | $0 | 0股 | +21.9万股 | 新买入 |
| IEQ资本IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #31 | $36.3万 | 17.5万股 | $18.5万 | 9.2万股 | +8.3万股+90.15% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #81 | $32.7万 | 15.8万股 | $15.6万 | 8.5万股 | +7.3万股+85.10% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #75 | $31.0万 | 15.0万股 | $2.2万 | 1.1万股 | +13.9万股+1,265.42% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #76 | $30.6万 | 14.8万股 | $273.2万 | 136.3万股 | -121.5万股-89.14% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #61 | $29.7万 | 14.4万股 | $0 | 0股 | +14.4万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #48 | $22.3万 | 10.8万股 | $0 | 0股 | +10.8万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #64 | $22.2万 | 10.7万股 | $0 | 0股 | +10.7万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #74 | $20.7万 | 10.0万股 | $0 | 0股 | +10.0万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #79 | $18.6万 | 9.0万股 | $0 | 0股 | +9.0万股 | 新买入 |
| Verdad Advisers, LP |
| 0.16% | — | #10 | $17.0万 | 8.2万股 | $0 | 0股 | +8.2万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #87 | $15.7万 | 7.6万股 | $115.8万 | 57.8万股 | -50.2万股-86.84% | 减仓 |
| 格雷厄姆资本管理Graham Capital Management, L.P. |
| <0.01% | <0.01% | #27 | $15.5万 | 7.5万股 | $7.6万 | 3.8万股 | +3.7万股+98.26% | 加仓 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #29 | $14.4万 | 7.0万股 | $8.9万 | 4.4万股 | +2.6万股+57.81% | 加仓 |
| 大都会人寿投资管理MetLife Investment Management, LLC |
| <0.01% | — | #36 | $13.4万 | 6.5万股 | $0 | 0股 | +6.5万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #73 | $10.5万 | 5.1万股 | $34 | 17股 | +5.1万股+297,752.94% | 加仓 |
| 未来资产环球ETFMIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #53 | $10.3万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
