| 富达投资FMR LLC |
| 0.07% | 0.11% | #147 | $17.21亿 | 1,614.4万股 | $21.52亿 | 1,316.0万股 | +298.3万股+22.67% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.02% | 0.05% | #262 | $16.85亿 | 1,580.8万股 | $27.27亿 | 1,667.8万股 | -87.0万股-5.22% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.05% | 0.09% | #185 | $11.10亿 | 1,040.8万股 | $16.96亿 | 1,037.2万股 | +3.6万股+0.35% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.06% | 0.24% | #168 | $10.92亿 | 1,042.8万股 | $37.03亿 | 2,415.0万股 | -1,372.2万股-56.82% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.02% | 0.04% | #276 | $10.44亿 | 979.1万股 | $15.77亿 | 964.2万股 | +14.9万股+1.54% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 4.7% | 6.97% | #10 | $9.38亿 | 879.6万股 | $12.14亿 | 742.1万股 | +137.5万股+18.53% | 加仓 |
| 资本国际投资者Capital International Investors |
| 0.18% | 0.21% | #104 | $8.78亿 | 823.8万股 | $9.15亿 | 559.5万股 | +264.3万股+47.24% | 加仓 |
| Darwin Global Management, Ltd. |
| 17.91% | 68.33% | #1 | $6.74亿 | 643.1万股 | $25.77亿 | 1,680.5万股 | -1,037.4万股-61.73% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.13% | 0.12% | #116 | $6.59亿 | 618.0万股 | $5.00亿 | 305.8万股 | +312.2万股+102.10% | 加仓 |
| Orbis Allan GrayOrbis Allan Gray Ltd |
| 2.23% | 1.29% | #21 | $6.48亿 | 607.6万股 | $3.06亿 | 187.3万股 | +420.4万股+224.46% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.02% | 0.03% | #294 | $6.45亿 | 605.2万股 | $9.08亿 | 555.2万股 | +50.0万股+9.01% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.3% | 0.55% | #81 | $6.33亿 | 593.8万股 | $9.23亿 | 564.3万股 | +29.5万股+5.23% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.92% | 1.71% | #38 | $5.80亿 | 544.2万股 | $10.67亿 | 652.7万股 | -108.6万股-16.63% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 4.41% | 7.88% | #11 | $5.16亿 | 484.3万股 | $7.92亿 | 484.3万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.05% | #266 | $4.49亿 | 422.0万股 | $7.33亿 | 445.0万股 | -23.0万股-5.17% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.04% | 0.06% | #217 | $3.63亿 | 340.5万股 | $5.06亿 | 309.3万股 | +31.2万股+10.10% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.04% | 0.02% | #218 | $3.60亿 | 337.8万股 | $1.33亿 | 174.3万股 | +163.5万股+93.80% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.04% | 0.07% | #207 | $3.40亿 | 318.8万股 | $4.27亿 | 261.3万股 | +57.5万股+22.00% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.11% | 0.09% | #128 | $3.12亿 | 292.8万股 | $2.12亿 | 129.5万股 | +163.3万股+126.10% | 加仓 |
| 杜肯家族办公室Duquesne Family Office LLC |
| 5.68% | 5.59% | #8 | $2.96亿 | 277.5万股 | $1.89亿 | 115.4万股 | +162.1万股+140.42% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.11% | — | #124 | $2.78亿 | 260.5万股 | $0 | 0股 | +260.5万股 | 新买入 |
| 瑞银集团UBS Group AG |
| 0.04% | 0.04% | #220 | $2.76亿 | 258.6万股 | $2.84亿 | 173.7万股 | +84.9万股+48.86% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.05% | 0.09% | #187 | $2.42亿 | 227.3万股 | $4.28亿 | 261.7万股 | -34.4万股-13.14% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.02% | 0.02% | #288 | $2.41亿 | 226.2万股 | $1.54亿 | 94.3万股 | +131.9万股+139.92% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.02% | #305 | $2.31亿 | 216.4万股 | $1.76亿 | 107.9万股 | +108.5万股+100.57% | 加仓 |
| Maverick资本MAVERICK CAPITAL LTD |
| 2.03% | — | #22 | $2.29亿 | 215.1万股 | $0 | 0股 | +215.1万股 | 新买入 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.17% | 0.03% | #107 | $1.79亿 | 168.2万股 | $2,428.5万 | 14.9万股 | +153.4万股+1,032.77% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.57% | 1.01% | #56 | $1.74亿 | 163.0万股 | $2.40亿 | 146.8万股 | +16.1万股+10.97% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.11% | — | #123 | $1.73亿 | 162.3万股 | $0 | 0股 | +162.3万股 | 新买入 |
| Caption管理Caption Management, LLC |
| 0.8% | 0.14% | #45 | $1.71亿 | 160.7万股 | $2,346.5万 | 14.4万股 | +146.3万股+1,019.65% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 6.74% | 11.73% | #6 | $1.71亿 | 160.0万股 | $2.45亿 | 150.0万股 | +10.0万股+6.67% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.03% | 0.06% | #228 | $1.49亿 | 140.2万股 | $2.21亿 | 135.5万股 | +4.7万股+3.47% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 3.13% | 0.04% | #16 | $1.49亿 | 139.3万股 | $164.1万 | 1.0万股 | +138.3万股+13,786.96% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.18% | 0.05% | #105 | $1.43亿 | 134.3万股 | $3,803.6万 | 23.3万股 | +111.1万股+477.42% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.03% | 0.04% | #255 | $1.42亿 | 133.5万股 | $1.99亿 | 121.5万股 | +12.0万股+9.88% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 2.65% | 4.19% | #19 | $1.41亿 | 132.6万股 | $2.05亿 | 125.4万股 | +7.1万股+5.70% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.02% | 0.03% | #316 | $1.40亿 | 131.5万股 | $2.12亿 | 129.4万股 | +2.1万股+1.65% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.02% | 0.04% | #269 | $1.40亿 | 131.3万股 | $2.06亿 | 126.3万股 | +5.0万股+3.96% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.1% | 0.03% | #132 | $1.33亿 | 125.0万股 | $3,875.7万 | 23.7万股 | +101.3万股+427.48% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | 0.01% | #391 | $1.32亿 | 123.3万股 | $1.39亿 | 96.4万股 | +27.0万股+28.01% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.12% | 0.19% | #118 | $1.30亿 | 122.0万股 | $1.79亿 | 110.2万股 | +11.8万股+10.71% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.03% | #309 | $1.29亿 | 121.4万股 | $1.75亿 | 106.9万股 | +14.5万股+13.52% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.82% | 1.13% | #43 | $1.13亿 | 105.7万股 | $1.13亿 | 68.9万股 | +36.8万股+53.49% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.02% | #390 | $1.09亿 | 102.3万股 | $2.46亿 | 150.2万股 | -47.9万股-31.90% | 减仓 |
| SEI投资SEI INVESTMENTS CO |
| 0.09% | 0.21% | #134 | $1.08亿 | 101.6万股 | $2.28亿 | 139.6万股 | -38.0万股-27.22% | 减仓 |
| NWI MANAGEMENT LP |
| 5% | 7.96% | #9 | $1.08亿 | 101.4万股 | $1.72亿 | 98.8万股 | +2.6万股+2.58% | 加仓 |
| Castle Hook合伙人Castle Hook Partners LP |
| 0.49% | 4.18% | #64 | $1.06亿 | 99.3万股 | $2.08亿 | 127.0万股 | -27.6万股-21.77% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| 0.01% | 0.01% | #365 | $1.06亿 | 99.2万股 | $7,450.0万 | 45.6万股 | +53.6万股+117.74% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.06% | 0.07% | #170 | $9,650.1万 | 90.5万股 | $9,888.0万 | 60.5万股 | +30.0万股+49.68% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.22% | 0.21% | #93 | $9,498.5万 | 89.1万股 | $6,019.3万 | 36.8万股 | +52.3万股+142.01% | 加仓 |
