| TCG Crossover 管理TCG Crossover Management, LLC |
| 2.51% | 2.76% | #5 | $1.04亿 | 567.3万股 | $9,649.9万 | 567.3万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #38 | $9,080.1万 | 493.2万股 | $2,746.8万 | 154.0万股 | +339.2万股+220.34% | 加仓 |
| FCPM III SERVICES B.V. |
| 10.1% | 10.17% | #1 | $7,580.0万 | 411.7万股 | $7,345.4万 | 411.7万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #51 | $6,384.8万 | 346.8万股 | $1,417.9万 | 79.5万股 | +267.3万股+336.37% | 加仓 |
| Venrock Adviser, LLC |
| 1.7% | 2.03% | #6 | $5,599.8万 | 304.2万股 | $5,426.4万 | 304.2万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #46 | $4,816.7万 | 261.6万股 | $1,995.3万 | 111.8万股 | +149.8万股+133.92% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 1.02% | 1.17% | #9 | $4,683.4万 | 254.4万股 | $4,538.4万 | 254.4万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.38% | 1.02% | #16 | $4,422.3万 | 240.2万股 | $9,642.5万 | 540.5万股 | -300.3万股-55.56% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $3,837.2万 | 208.4万股 | $2,557.0万 | 143.3万股 | +65.1万股+45.42% | 加仓 |
| Caligan Partners LP |
| 1.67% | 2.29% | #7 | $3,544.0万 | 192.5万股 | $3,434.3万 | 192.5万股 | 00.00% | 持仓不变 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 0.6% | 0.64% | #11 | $3,221.8万 | 175.0万股 | $3,122.0万 | 175.0万股 | 00.00% | 持仓不变 |
| GREAT POINT PARTNERS LLC |
| 5.91% | 7.18% | #3 | $3,129.7万 | 170.0万股 | $3,122.0万 | 175.0万股 | -5.0万股-2.86% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #50 | $1,956.4万 | 106.2万股 | $611.5万 | 34.3万股 | +72.0万股+210.14% | 加仓 |
| NEXTBio Capital Management LP |
| 7.53% | 8.28% | #2 | $1,637.0万 | 88.9万股 | $1,783.9万 | 100.0万股 | -11.1万股-11.08% | 减仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.52% | — | #13 | $1,555.6万 | 84.5万股 | $0 | 0股 | +84.5万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 0.58% | — | #12 | $1,253.0万 | 68.1万股 | $0 | 0股 | +68.1万股 | 新买入 |
| Logos Global Management LP |
| 0.52% | 0.67% | #14 | $1,196.7万 | 65.0万股 | $1,338.0万 | 75.0万股 | -10.0万股-13.33% | 减仓 |
| Rosalind Advisors, Inc. |
| 2.83% | 5.02% | #4 | $1,194.1万 | 64.9万股 | $1,248.8万 | 70.0万股 | -5.1万股-7.34% | 减仓 |
| NAN FUNG TRINITY (HK) Ltd |
| 1.18% | — | #8 | $1,190.3万 | 64.7万股 | $0 | 0股 | +64.7万股 | 新买入 |
| BRAIDWELL LP |
| 0.39% | 0.28% | #15 | $1,055.1万 | 57.3万股 | $832.7万 | 46.7万股 | +10.6万股+22.78% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.14% | 0.13% | #21 | $1,028.6万 | 55.9万股 | $991.4万 | 55.6万股 | +3,000股+0.54% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #49 | $908.1万 | 49.3万股 | $871.2万 | 48.8万股 | +4,910股+1.01% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $788.1万 | 42.8万股 | $461.3万 | 25.9万股 | +16.9万股+65.54% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 1% | 0.91% | #10 | $766.6万 | 41.6万股 | $574.3万 | 32.2万股 | +9.5万股+29.36% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | — | #26 | $699.1万 | 38.0万股 | $0 | 0股 | +38.0万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #71 | $626.6万 | 34.0万股 | $0 | 0股 | +34.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #59 | $605.5万 | 32.9万股 | $467.2万 | 26.2万股 | +6.7万股+25.58% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #56 | $605.2万 | 32.9万股 | $115.2万 | 6.5万股 | +26.4万股+409.29% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #48 | $553.6万 | 30.1万股 | $331.0万 | 18.6万股 | +11.5万股+62.09% | 加仓 |
| Clearline Capital LP |
| 0.31% | 0.3% | #17 | $525.2万 | 28.5万股 | $581.9万 | 32.6万股 | -4.1万股-12.54% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #76 | $327.2万 | 17.8万股 | $201.4万 | 11.3万股 | +6.5万股+57.44% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #67 | $295.3万 | 16.0万股 | $265.4万 | 14.9万股 | +1.2万股+7.83% | 加仓 |
| Eversept Partners, LP |
| 0.14% | — | #20 | $275.6万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #69 | $223.5万 | 12.1万股 | $39.6万 | 2.2万股 | +9.9万股+446.44% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #70 | $179.9万 | 9.8万股 | $0 | 0股 | +9.8万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | 0.02% | #47 | $176.1万 | 9.6万股 | $2,057.4万 | 115.3万股 | -105.8万股-91.71% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #64 | $174.6万 | 9.5万股 | $0 | 0股 | +9.5万股 | 新买入 |
| Axiom投资者AXIOM INVESTORS LLC /DE |
| 0.01% | 0.02% | #29 | $169.6万 | 9.2万股 | $170.8万 | 9.6万股 | -3,640股-3.80% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | — | #27 | $152.1万 | 8.3万股 | $0 | 0股 | +8.3万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #79 | $149.2万 | 8.1万股 | $729.3万 | 40.9万股 | -32.8万股-80.17% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | 0.04% | #31 | $130.5万 | 7.1万股 | $308.7万 | 17.3万股 | -10.2万股-59.03% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #82 | $125.7万 | 6.8万股 | $20.7万 | 1.2万股 | +5.7万股+488.80% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #65 | $116.2万 | 6.3万股 | $9.6万 | 5,373股 | +5.8万股+1,074.95% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #88 | $113.3万 | 6.2万股 | $21.7万 | 4,456股 | +5.7万股+1,281.53% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #54 | $105.9万 | 5.8万股 | $0 | 0股 | +5.8万股 | 新买入 |
| ALPS顾问ALPS ADVISORS INC |
| <0.01% | — | #36 | $101.3万 | 5.5万股 | $0 | 0股 | +5.5万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #62 | $100.6万 | 5.5万股 | $0 | 0股 | +5.5万股 | 新买入 |
| JOHNSON & JOHNSON |
| 0.12% | 0.15% | #22 | $98.9万 | 5.4万股 | $95.9万 | 5.4万股 | 00.00% | 持仓不变 |
| Rafferty资产管理Rafferty Asset Management, LLC |
| <0.01% | <0.01% | #42 | $89.9万 | 4.9万股 | $90.1万 | 5.1万股 | -1,687股-3.34% | 减仓 |
| Walleye资本Walleye Capital LLC |
| <0.01% | — | #40 | $85.8万 | 4.7万股 | $0 | 0股 | +4.7万股 | 新买入 |
