| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| <0.01% | <0.01% | #17 | $599.6万 | 461.2万股 | $609.5万 | 472.5万股 | -11.3万股-2.38% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #40 | $380.0万 | 292.3万股 | $586.5万 | 362.1万股 | -69.8万股-19.27% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.12% | 0.15% | #4 | $362.5万 | 278.8万股 | $359.7万 | 278.8万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #64 | $211.9万 | 163.0万股 | $210.8万 | 163.4万股 | -4,045股-0.25% | 减仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.01% | — | #15 | $159.1万 | 122.4万股 | $0 | 0股 | +122.4万股 | 新买入 |
| Almitas Capital LLC |
| 0.32% | — | #1 | $138.3万 | 106.4万股 | $0 | 0股 | +106.4万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #77 | $114.7万 | 88.2万股 | $343.3万 | 266.2万股 | -177.9万股-66.84% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #49 | $114.7万 | 88.2万股 | $19.2万 | 14.9万股 | +73.3万股+493.68% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.16% | 0.4% | #3 | $106.0万 | 81.5万股 | $99.1万 | 76.8万股 | +4.7万股+6.14% | 加仓 |
| BRAIDWELL LP |
| 0.04% | 0.03% | #9 | $97.8万 | 75.3万股 | $97.1万 | 75.3万股 | 00.00% | 持仓不变 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $96.8万 | 74.5万股 | $46.1万 | 35.8万股 | +38.7万股+108.34% | 加仓 |
| Parkman Healthcare Partners LLC |
| 0.09% | 0.1% | #6 | $84.1万 | 64.7万股 | $97.5万 | 75.6万股 | -10.9万股-14.43% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #67 | $58.9万 | 45.3万股 | $121.9万 | 94.4万股 | -49.2万股-52.07% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #27 | $55.3万 | 42.5万股 | $41.3万 | 32.0万股 | +10.5万股+32.72% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.03% | #10 | $52.6万 | 40.4万股 | $48.3万 | 37.4万股 | +3.0万股+8.01% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #42 | $52.3万 | 40.2万股 | $150.1万 | 116.4万股 | -76.1万股-65.43% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $52.3万 | 40.2万股 | $8.7万 | 6.7万股 | +33.5万股+499.18% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #39 | $42.6万 | 32.8万股 | $43.2万 | 33.5万股 | -7,546股-2.25% | 减仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| <0.01% | <0.01% | #18 | $37.1万 | 28.5万股 | $36.8万 | 28.5万股 | 00.00% | 持仓不变 |
| CFM WEALTH PARTNERS LLC |
| 0.04% | 0.05% | #7 | $34.3万 | 26.4万股 | $34.1万 | 26.4万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #55 | $32.6万 | 25.1万股 | $36.3万 | 28.1万股 | -3.1万股-10.93% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #37 | $30.0万 | 23.1万股 | $0 | 0股 | +23.1万股 | 新买入 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #32 | $29.0万 | 22.3万股 | $21.2万 | 16.6万股 | +5.7万股+34.15% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #51 | $27.2万 | 21.0万股 | $0 | 0股 | +21.0万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #66 | $26.5万 | 20.4万股 | $27.1万 | 21.0万股 | -5,648股-2.69% | 减仓 |
| Birchview Capital, LP |
| 0.12% | 0.18% | #5 | $26.1万 | 20.1万股 | $32.3万 | 25.0万股 | -5.0万股-19.85% | 减仓 |
| Centiva资本Centiva Capital, LP |
| <0.01% | <0.01% | #19 | $26.0万 | 20.0万股 | $19.9万 | 15.4万股 | +4.6万股+30.03% | 加仓 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.2% | 0.19% | #2 | $26.0万 | 20.0万股 | $20.3万 | 15.8万股 | +4.3万股+26.98% | 加仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #46 | $24.9万 | 19.4万股 | $1.8万 | 1.4万股 | +18.0万股+1,275.77% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #87 | $24.9万 | 19.2万股 | $104.4万 | 80.9万股 | -61.8万股-76.33% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #34 | $23.9万 | 18.4万股 | $10.6万 | 8.2万股 | +10.1万股+122.52% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #81 | $19.5万 | 15.0万股 | $22.1万 | 17.1万股 | -2.1万股-12.55% | 减仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | 0.01% | #14 | $17.7万 | 13.6万股 | $17.7万 | 13.7万股 | -1,331股-0.97% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #80 | $17.6万 | 13.5万股 | $28.8万 | 22.3万股 | -8.8万股-39.43% | 减仓 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #20 | $15.3万 | 11.8万股 | $10.3万 | 8.0万股 | +3.8万股+47.40% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| <0.01% | <0.01% | #30 | $14.3万 | 11.0万股 | $14.2万 | 11.0万股 | 00.00% | 持仓不变 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #35 | $14.1万 | 10.8万股 | $0 | 0股 | +10.8万股 | 新买入 |
| 蒙特利尔银行BANK OF MONTREAL /CAN/ |
| <0.01% | — | #63 | $13.8万 | 10.6万股 | $0 | 0股 | +10.6万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #79 | $13.5万 | 10.4万股 | $45.8万 | 35.5万股 | -25.1万股-70.64% | 减仓 |
| Redhawk Wealth Advisors, Inc. |
| 0.01% | <0.01% | #13 | $13.0万 | 10.0万股 | $4.5万 | 3.5万股 | +6.5万股+187.17% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| <0.01% | <0.01% | #21 | $12.8万 | 9.8万股 | $11.0万 | 8.5万股 | +1.3万股+15.19% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #72 | $12.7万 | 9.8万股 | $18.3万 | 14.2万股 | -4.4万股-31.09% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #53 | $11.3万 | 8.7万股 | $8.9万 | 6.9万股 | +1.8万股+26.18% | 加仓 |
| IEQ资本IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #31 | $9.0万 | 6.9万股 | $2.8万 | 2.2万股 | +4.8万股+220.37% | 加仓 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #28 | $8.3万 | 6.4万股 | $0 | 0股 | +6.4万股 | 新买入 |
| 工程师之门Engineers Gate Manager LP |
| <0.01% | <0.01% | #26 | $8.1万 | 6.3万股 | $7.2万 | 5.6万股 | +6,438股+11.47% | 加仓 |
| 美世全球顾问MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | <0.01% | #48 | $8.0万 | 6.1万股 | $6.3万 | 4.9万股 | +1.3万股+25.77% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $7.9万 | 6.1万股 | $7.9万 | 6.1万股 | 00.00% | 持仓不变 |
| Berger Financial Group, Inc |
| <0.01% | <0.01% | #16 | $7.0万 | 5.4万股 | $7.0万 | 5.4万股 | 00.00% | 持仓不变 |
| 布莱顿·琼斯BRIGHTON JONES LLC |
| <0.01% | — | #24 | $6.9万 | 5.3万股 | $0 | 0股 | +5.3万股 | 新买入 |
