| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.94% | — | #7 | $2,730.3万 | 1,306.4万股 | $0 | 0股 | +1,306.4万股 | 新买入 |
| B Group, Inc. |
| 11.2% | 14.81% | #1 | $2,385.6万 | 1,141.4万股 | $1,997.5万 | 1,141.4万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #47 | $2,316.0万 | 1,108.1万股 | $1,524.5万 | 871.1万股 | +237.0万股+27.21% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #39 | $2,239.4万 | 1,068.9万股 | $0 | 0股 | +1,068.9万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #72 | $2,181.3万 | 1,043.7万股 | $328.4万 | 187.6万股 | +856.0万股+456.23% | 加仓 |
| Octagon Capital Advisors LP |
| 1.93% | 1.99% | #5 | $2,147.8万 | 1,027.6万股 | $1,798.4万 | 1,027.6万股 | 00.00% | 持仓不变 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.26% | 0.31% | #16 | $1,760.8万 | 842.5万股 | $1,562.4万 | 892.8万股 | -50.3万股-5.63% | 减仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.13% | 0.13% | #20 | $1,488.9万 | 712.4万股 | $1,246.7万 | 712.4万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #51 | $1,209.1万 | 578.5万股 | $1,012.4万 | 578.5万股 | 00.00% | 持仓不变 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #36 | $1,098.0万 | 525.3万股 | $72.1万 | 41.2万股 | +484.2万股+1,175.80% | 加仓 |
| Boxer Capital Management, LLC |
| 0.76% | 1.1% | #11 | $1,003.2万 | 480.0万股 | $840.0万 | 480.0万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #32 | $940.5万 | 450.0万股 | $787.5万 | 450.0万股 | 00.00% | 持仓不变 |
| Eversept Partners, LP |
| 0.45% | 0.46% | #13 | $874.2万 | 418.3万股 | $872.8万 | 498.7万股 | -80.5万股-16.13% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #67 | $786.1万 | 376.0万股 | $270.7万 | 154.6万股 | +221.4万股+143.20% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #53 | $774.1万 | 370.4万股 | $508.4万 | 290.5万股 | +79.9万股+27.51% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #61 | $747.8万 | 357.8万股 | $940.4万 | 537.4万股 | -179.6万股-33.42% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | 0.01% | #38 | $655.6万 | 313.7万股 | $548.9万 | 313.7万股 | 00.00% | 持仓不变 |
| Squadron Capital Management LLC |
| 1.95% | 1.92% | #4 | $627.0万 | 300.0万股 | $525.0万 | 300.0万股 | 00.00% | 持仓不变 |
| Propel Bio Management, LLC |
| 2.82% | 1.26% | #2 | $539.7万 | 258.2万股 | $199.7万 | 111.5万股 | +146.7万股+131.60% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.12% | 0.12% | #22 | $522.5万 | 250.0万股 | $437.5万 | 250.0万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #84 | $517.4万 | 247.6万股 | $111.3万 | 63.6万股 | +183.9万股+289.13% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #74 | $517.1万 | 247.4万股 | $7,409 | 8,618股 | +246.5万股+28,608.16% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.09% | 0.08% | #24 | $487.6万 | 233.3万股 | $408.3万 | 233.3万股 | 00.00% | 持仓不变 |
| GREAT POINT PARTNERS LLC |
| 0.9% | 1.37% | #8 | $477.5万 | 228.5万股 | $596.0万 | 340.6万股 | -112.1万股-32.91% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.62% | 0.48% | #12 | $471.7万 | 225.7万股 | $303.4万 | 173.3万股 | +52.4万股+30.21% | 加仓 |
| HighVista Strategies LLC |
| 0.97% | 0.98% | #6 | $424.5万 | 203.1万股 | $353.4万 | 201.9万股 | +1.2万股+0.57% | 加仓 |
| Siren, L.L.C. |
| 0.08% | — | #25 | $418.0万 | 200.0万股 | $0 | 0股 | +200.0万股 | 新买入 |
| Artia Global Partners LP |
| 0.77% | 0.7% | #10 | $416.4万 | 199.2万股 | $348.7万 | 199.2万股 | 00.00% | 持仓不变 |
| 安本标准投资Aberdeen Group plc |
| 0.01% | <0.01% | #42 | $399.2万 | 191.0万股 | $116.0万 | 66.3万股 | +124.7万股+188.16% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | 0.01% | #45 | $392.0万 | 187.6万股 | $572.4万 | 327.1万股 | -139.5万股-42.65% | 减仓 |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.89% | 0.54% | #9 | $361.8万 | 173.1万股 | $215.5万 | 123.1万股 | +49.9万股+40.56% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.17% | 0.23% | #19 | $360.9万 | 172.7万股 | $396.3万 | 226.5万股 | -53.8万股-23.76% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #94 | $360.1万 | 172.3万股 | $250.1万 | 142.9万股 | +29.4万股+20.54% | 加仓 |
| Ally Bridge Group (NY) LLC |
| 2.27% | — | #3 | $256.9万 | 122.9万股 | $0 | 0股 | +122.9万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #73 | $250.3万 | 119.8万股 | $49.1万 | 28.1万股 | +91.7万股+326.73% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #50 | $235.1万 | 112.5万股 | $254.5万 | 145.4万股 | -33.0万股-22.66% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #76 | $212.5万 | 101.7万股 | $2.5万 | 1.4万股 | +100.3万股+7,024.79% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #88 | $207.8万 | 99.4万股 | $0 | 0股 | +99.4万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #65 | $202.6万 | 96.9万股 | $0 | 0股 | +96.9万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $195.2万 | 93.4万股 | $368.1万 | 210.3万股 | -116.9万股-55.59% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $185.2万 | 88.6万股 | $115.4万 | 65.9万股 | +22.7万股+34.37% | 加仓 |
| Ikarian Capital, LLC |
| 0.17% | 0.04% | #18 | $156.8万 | 75.0万股 | $48.1万 | 27.5万股 | +47.5万股+172.75% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #79 | $154.1万 | 73.7万股 | $204.2万 | 116.7万股 | -43.0万股-36.82% | 减仓 |
| BIT Capital GmbH |
| 0.04% | 0.01% | #28 | $120.0万 | 57.4万股 | $27.1万 | 15.5万股 | +41.9万股+270.32% | 加仓 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.01% | 0.01% | #33 | $94.2万 | 45.1万股 | $61.3万 | 35.0万股 | +10.1万股+28.73% | 加仓 |
| Creek Drive Management Group LLC |
| 0.45% | 0.22% | #14 | $92.0万 | 44.0万股 | $94.5万 | 54.0万股 | -10.0万股-18.52% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | <0.01% | #35 | $91.4万 | 43.7万股 | $29.7万 | 17.0万股 | +26.7万股+157.67% | 加仓 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| 0.06% | 0.04% | #26 | $91.3万 | 43.7万股 | $56.9万 | 32.5万股 | +11.2万股+34.37% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #85 | $90.9万 | 43.5万股 | $13.3万 | 7.6万股 | +35.9万股+472.35% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #60 | $83.3万 | 39.9万股 | $482.0万 | 275.4万股 | -235.6万股-85.52% | 减仓 |
