| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #13 | $2,758.1万 | 630.8万股 | $0 | 0股 | +630.8万股 | 新买入 |
| 5AM Venture Management, LLC |
| 8.91% | 7.19% | #1 | $2,564.8万 | 586.9万股 | $2,588.3万 | 586.9万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #17 | $2,143.2万 | 490.4万股 | $2,175.6万 | 493.3万股 | -2.9万股-0.59% | 减仓 |
| Vivo Capital, LLC |
| 1.69% | 1.56% | #4 | $1,855.8万 | 424.7万股 | $1,872.7万 | 424.7万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.02% | #11 | $1,125.6万 | 257.6万股 | $1,160.9万 | 263.2万股 | -5.7万股-2.15% | 减仓 |
| a16z资本管理a16z Capital Management, L.L.C. |
| 0.75% | 0.73% | #7 | $937.3万 | 212.5万股 | $937.3万 | 212.5万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #12 | $856.9万 | 196.1万股 | $864.7万 | 196.1万股 | 00.00% | 持仓不变 |
| Trails Edge Capital Partners, LP |
| 1.34% | 1.96% | #5 | $844.7万 | 193.3万股 | $855.3万 | 194.0万股 | -6,626股-0.34% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #32 | $718.5万 | 164.4万股 | $201.3万 | 45.6万股 | +118.8万股+260.26% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #28 | $670.1万 | 153.3万股 | $676.8万 | 153.5万股 | -1,279股-0.08% | 减仓 |
| Enavate Sciences GP, LLC |
| 1.8% | 2.75% | #3 | $623.0万 | 142.6万股 | $966.2万 | 219.1万股 | -76.5万股-34.93% | 减仓 |
| Stonepine Capital Management, LLC |
| 0.93% | 2.45% | #6 | $607.3万 | 139.0万股 | $612.8万 | 139.0万股 | 00.00% | 持仓不变 |
| HARBOURVEST PARTNERS LLC |
| 3.27% | 5.56% | #2 | $555.8万 | 127.2万股 | $560.9万 | 127.2万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #27 | $347.8万 | 79.6万股 | $168.9万 | 38.3万股 | +41.3万股+107.84% | 加仓 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.08% | 0.05% | #10 | $316.9万 | 72.5万股 | $149.7万 | 34.0万股 | +38.6万股+113.58% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.3% | 0.29% | #8 | $285.6万 | 65.4万股 | $288.2万 | 65.4万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #41 | $158.3万 | 36.2万股 | $64.8万 | 14.7万股 | +21.5万股+146.63% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #29 | $108.7万 | 24.9万股 | $31.2万 | 7.1万股 | +17.8万股+251.90% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #33 | $105.5万 | 24.1万股 | $34.6万 | 7.8万股 | +16.3万股+208.12% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #23 | $98.8万 | 22.6万股 | $86.0万 | 19.5万股 | +3.1万股+15.93% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #43 | $96.5万 | 22.1万股 | $0 | 0股 | +22.1万股 | 新买入 |
| Birchview Capital, LP |
| 0.24% | — | #9 | $52.4万 | 12.0万股 | $0 | 0股 | +12.0万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #21 | $45.7万 | 10.5万股 | $48.0万 | 10.9万股 | -4,265股-3.92% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #39 | $42.2万 | 9.7万股 | $8.8万 | 2.0万股 | +7.7万股+383.30% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #38 | $36.5万 | 8.3万股 | $8.3万 | 1.9万股 | +6.5万股+345.67% | 加仓 |
| 胜利资本管理VICTORY CAPITAL MANAGEMENT INC |
| <0.01% | <0.01% | #25 | $36.0万 | 8.2万股 | $36.4万 | 8.2万股 | 00.00% | 持仓不变 |
| 康托·菲茨杰拉德CANTOR FITZGERALD, L. P. |
| <0.01% | — | #15 | $23.4万 | 5.4万股 | $0 | 0股 | +5.4万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $19.2万 | 4.4万股 | $37.9万 | 8.6万股 | -4.2万股-48.90% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #42 | $18.4万 | 4.2万股 | $0 | 0股 | +4.2万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #45 | $13.8万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| <0.01% | — | #14 | $13.5万 | 3.1万股 | $0 | 0股 | +3.1万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #48 | $12.6万 | 2.9万股 | $0 | 0股 | +2.9万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #50 | $11.5万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #16 | $10.9万 | 2.5万股 | $11.0万 | 2.5万股 | 00.00% | 持仓不变 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #34 | $10.6万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | — | #53 | $9.8万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #31 | $8.7万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| <0.01% | <0.01% | #22 | $8.2万 | 1.9万股 | $21.4万 | 4.9万股 | -3.0万股-61.53% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #56 | $7.8万 | 1.8万股 | $13.8万 | 3.1万股 | -1.3万股-43.03% | 减仓 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #18 | $6.9万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #47 | $6.5万 | 1.5万股 | $4.4万 | 9,887股 | +5,088股+51.46% | 加仓 |
| 未来资产环球ETFMIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #35 | $6.4万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #40 | $6.2万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #57 | $5.8万 | 1.3万股 | $0 | 0股 | +1.3万股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #46 | $5.1万 | 1.2万股 | $5.1万 | 1.2万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #54 | $5.0万 | 1.2万股 | $4.0万 | 9,081股 | +2,444股+26.91% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #59 | $5.0万 | 1.1万股 | $9 | 3股 | +1.1万股+381,933.33% | 加仓 |
| 新泽西州警察消防退休系统Police & Firemen's Retirement System of New Jersey |
| <0.01% | — | #19 | $4.9万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #49 | $4.2万 | 9,669股 | $159 | 36股 | +9,633股+26,758.33% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #55 | $3.1万 | 7,096股 | $15.3万 | 3.5万股 | -2.8万股-79.55% | 减仓 |
