| Column Group LLC |
| 56.46% | 55.45% | #1 | $4,974.5万 | 191.7万股 | $5,584.1万 | 191.7万股 | 00.00% | 持仓不变 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.92% | 1.23% | #8 | $3,822.7万 | 147.3万股 | $4,291.1万 | 147.3万股 | 00.00% | 持仓不变 |
| Boxer Capital Management, LLC |
| 2.03% | 2.93% | #6 | $2,696.4万 | 110.6万股 | $2,232.3万 | 76.6万股 | +33.9万股+44.29% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #22 | $1,772.6万 | 68.3万股 | $2,129.8万 | 73.1万股 | -4.8万股-6.57% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.02% | — | #20 | $1,723.8万 | 66.4万股 | $0 | 0股 | +66.4万股 | 新买入 |
| Venrock Adviser, LLC |
| 0.5% | 0.69% | #11 | $1,642.5万 | 63.3万股 | $1,843.7万 | 63.3万股 | 00.00% | 持仓不变 |
| STEMPOINT CAPITAL LP |
| 1.96% | 2.48% | #7 | $1,378.7万 | 60.3万股 | $1,346.1万 | 52.6万股 | +7.7万股+14.68% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.2% | 0.13% | #14 | $1,307.8万 | 50.4万股 | $668.2万 | 22.9万股 | +27.5万股+119.70% | 加仓 |
| Spruce Street Capital LP |
| 2.2% | 3.03% | #5 | $1,121.1万 | 43.2万股 | $1,258.5万 | 43.2万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #43 | $1,024.7万 | 39.5万股 | $81.1万 | 2.8万股 | +36.7万股+1,317.77% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #40 | $1,018.7万 | 39.3万股 | $492.6万 | 16.9万股 | +22.3万股+132.15% | 加仓 |
| BRAIDWELL LP |
| 0.38% | 0.38% | #12 | $1,014.0万 | 39.1万股 | $1,153.8万 | 39.6万股 | -5,347股-1.35% | 减仓 |
| Kalehua Capital Management LLC |
| 7.16% | 7.94% | #2 | $999.5万 | 38.5万股 | $1,122.0万 | 38.5万股 | 00.00% | 持仓不变 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.18% | 0.28% | #15 | $790.6万 | 30.5万股 | $986.4万 | 33.9万股 | -3.4万股-10.02% | 减仓 |
| 5AM Venture Management, LLC |
| 2.44% | 3.13% | #4 | $703.9万 | 27.1万股 | $1,128.8万 | 38.8万股 | -11.6万股-30.00% | 减仓 |
| Vivo Capital, LLC |
| 0.62% | 0.63% | #9 | $674.7万 | 26.0万股 | $757.4万 | 26.0万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #21 | $532.1万 | 20.5万股 | $593.9万 | 20.4万股 | +1,144股+0.56% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #37 | $523.4万 | 20.2万股 | $191.9万 | 6.6万股 | +13.6万股+206.23% | 加仓 |
| ACUTA CAPITAL PARTNERS, LLC |
| 3.14% | 3.55% | #3 | $450.0万 | 17.3万股 | $503.5万 | 17.3万股 | +548股+0.32% | 加仓 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA |
| 0.08% | 0.11% | #17 | $345.7万 | 13.3万股 | $301.0万 | 13.3万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #47 | $345.4万 | 13.3万股 | $80.8万 | 2.8万股 | +10.5万股+380.00% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #39 | $294.6万 | 11.4万股 | $75.3万 | 2.6万股 | +8.8万股+339.17% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #26 | $230.1万 | 8.9万股 | $258.2万 | 8.9万股 | 00.00% | 持仓不变 |
| Euclidean Capital LLC |
| 0.52% | 0.65% | #10 | $227.6万 | 8.8万股 | $255.5万 | 8.8万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #28 | $184.6万 | 7.1万股 | $115.0万 | 3.9万股 | +3.2万股+80.13% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.27% | 0.39% | #13 | $176.8万 | 6.8万股 | $96.1万 | 3.3万股 | +3.5万股+106.03% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #41 | $165.1万 | 6.4万股 | $35.7万 | 1.2万股 | +5.1万股+418.62% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $154.6万 | 6.0万股 | $103.1万 | 3.5万股 | +2.4万股+68.34% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.06% | 0.04% | #19 | $143.0万 | 5.5万股 | $160.6万 | 5.5万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #54 | $132.4万 | 5.1万股 | $0 | 0股 | +5.1万股 | 新买入 |
| Eversept Partners, LP |
| 0.06% | 0.09% | #18 | $124.0万 | 4.8万股 | $170.8万 | 5.9万股 | -1.1万股-18.50% | 减仓 |
| Walleye资本Walleye Capital LLC |
| <0.01% | — | #25 | $100.8万 | 3.9万股 | $0 | 0股 | +3.9万股 | 新买入 |
| Ellsworth Advisors, LLC |
| 0.14% | — | #16 | $85.6万 | 3.9万股 | $0 | 0股 | +3.9万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #57 | $81.2万 | 3.1万股 | $0 | 0股 | +3.1万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #49 | $75.8万 | 2.9万股 | $61.9万 | 2.1万股 | +7,982股+37.57% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #51 | $72.0万 | 2.8万股 | $63.3万 | 2.2万股 | +6,026股+27.75% | 加仓 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| <0.01% | 0.01% | #27 | $62.3万 | 2.4万股 | $208.9万 | 7.2万股 | -4.8万股-66.52% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | — | #24 | $43.7万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #55 | $42.3万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #52 | $39.9万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| LMR合伙人LMR Partners LLP |
| <0.01% | <0.01% | #29 | $35.2万 | 1.4万股 | $68.6万 | 2.4万股 | -1.0万股-42.45% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #34 | $32.1万 | 1.2万股 | $143.1万 | 4.9万股 | -3.7万股-74.81% | 减仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #30 | $26.4万 | 1.0万股 | $29.7万 | 1.0万股 | 00.00% | 持仓不变 |
| 费雪资产管理Fisher Asset Management, LLC |
| <0.01% | — | #50 | $25.5万 | 9,840股 | $0 | 0股 | +9,840股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #53 | $25.4万 | 9,780股 | $0 | 0股 | +9,780股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #42 | $21.1万 | 8,130股 | $0 | 0股 | +8,130股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #48 | $20.8万 | 8,029股 | $21.3万 | 7,325股 | +704股+9.61% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #56 | $18.9万 | 7,302股 | $0 | 0股 | +7,302股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #64 | $18.6万 | 7,151股 | $44.8万 | 3.5万股 | -2.8万股-79.43% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #61 | $17.4万 | 6,698股 | $0 | 0股 | +6,698股 | 新买入 |
