| TCG Crossover 管理TCG Crossover Management, LLC |
| 1.63% | — | #5 | $6,768.7万 | 953.3万股 | $0 | 0股 | +953.3万股 | 新买入 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 0.94% | 0.75% | #12 | $5,116.4万 | 720.6万股 | $2,925.5万 | 437.3万股 | +283.3万股+64.79% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 1.1% | 0.88% | #10 | $5,041.0万 | 710.0万股 | $3,411.9万 | 510.0万股 | +200.0万股+39.22% | 加仓 |
| Long Focus 资本管理Long Focus Capital Management, LLC |
| 0.94% | 0.81% | #11 | $3,634.9万 | 512.0万股 | $3,090.5万 | 462.0万股 | +50.0万股+10.82% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #64 | $3,342.4万 | 470.8万股 | $2,399.5万 | 358.7万股 | +112.1万股+31.26% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.05% | #30 | $3,294.4万 | 464.0万股 | $3,265.5万 | 488.1万股 | -24.1万股-4.94% | 减仓 |
| Caligan Partners LP |
| 1.44% | 0.1% | #9 | $3,051.8万 | 429.8万股 | $153.8万 | 23.0万股 | +406.8万股+1,769.91% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $2,911.2万 | 410.0万股 | $1,501.1万 | 224.4万股 | +185.7万股+82.74% | 加仓 |
| FCPM III SERVICES B.V. |
| 3.84% | — | #2 | $2,878.2万 | 405.4万股 | $0 | 0股 | +405.4万股 | 新买入 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.45% | — | #18 | $2,366.7万 | 333.3万股 | $0 | 0股 | +333.3万股 | 新买入 |
| Medicxi Ventures Management (Jersey) Ltd |
| 12.16% | 2.07% | #1 | $2,158.3万 | 304.0万股 | $2,033.7万 | 304.0万股 | 00.00% | 持仓不变 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.7% | 0.52% | #16 | $2,095.2万 | 295.1万股 | $1,416.7万 | 211.8万股 | +83.3万股+39.35% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #40 | $1,778.8万 | 250.0万股 | $0 | 0股 | +250.0万股 | 新买入 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.15% | — | #24 | $1,775.0万 | 250.0万股 | $0 | 0股 | +250.0万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | <0.01% | #34 | $1,671.8万 | 235.5万股 | $373.1万 | 55.8万股 | +179.7万股+322.24% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #43 | $1,471.6万 | 207.3万股 | $1,386.7万 | 207.3万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $1,246.3万 | 175.5万股 | $877.0万 | 131.1万股 | +44.4万股+33.86% | 加仓 |
| Redmile Group, LLC |
| 0.79% | — | #13 | $1,183.3万 | 166.7万股 | $0 | 0股 | +166.7万股 | 新买入 |
| EcoR1 Capital, LLC |
| 0.58% | — | #17 | $1,183.3万 | 166.7万股 | $0 | 0股 | +166.7万股 | 新买入 |
| Trails Edge Capital Partners, LP |
| 1.63% | — | #6 | $1,024.8万 | 144.3万股 | $0 | 0股 | +144.3万股 | 新买入 |
| Foresite Capital Management VI LLC |
| 1.47% | — | #8 | $946.7万 | 133.3万股 | $0 | 0股 | +133.3万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #78 | $868.3万 | 122.3万股 | $645.4万 | 96.5万股 | +25.8万股+26.78% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | — | #33 | $859.2万 | 121.0万股 | $0 | 0股 | +121.0万股 | 新买入 |
| Bellevue 集团Bellevue Group AG |
| 0.17% | — | #23 | $828.3万 | 116.7万股 | $0 | 0股 | +116.7万股 | 新买入 |
| Vivo Capital, LLC |
| 0.76% | — | #14 | $828.3万 | 116.7万股 | $0 | 0股 | +116.7万股 | 新买入 |
| ACORN CAPITAL ADVISORS, LLC |
| 1.8% | 1.13% | #4 | $659.6万 | 92.9万股 | $398.6万 | 59.6万股 | +33.3万股+55.95% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.09% | <0.01% | #25 | $643.5万 | 90.6万股 | $13.6万 | 2.0万股 | +88.6万股+4,342.49% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #73 | $618.7万 | 87.1万股 | $261.8万 | 39.1万股 | +48.0万股+122.66% | 加仓 |
| LEVIN CAPITAL STRATEGIES, L.P. |
| 0.4% | 0.48% | #19 | $595.0万 | 83.8万股 | $629.8万 | 94.1万股 | -10.3万股-10.98% | 减仓 |
| B Group, Inc. |
| 2.55% | 2.96% | #3 | $542.6万 | 76.4万股 | $399.8万 | 59.8万股 | +16.7万股+27.89% | 加仓 |
| STEMPOINT CAPITAL LP |
| 0.72% | — | #15 | $507.1万 | 71.4万股 | $0 | 0股 | +71.4万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #51 | $452.4万 | 63.7万股 | $265.7万 | 39.7万股 | +24.0万股+60.44% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #55 | $439.3万 | 61.9万股 | $373.2万 | 55.8万股 | +6.1万股+10.88% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #48 | $438.4万 | 61.7万股 | $734.3万 | 109.8万股 | -48.0万股-43.75% | 减仓 |
| AWM Investment Company, Inc. |
| 0.36% | — | #20 | $419.8万 | 59.1万股 | $0 | 0股 | +59.1万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #65 | $390.1万 | 54.9万股 | $288.0万 | 43.1万股 | +11.9万股+27.63% | 加仓 |
| Regency Capital Management Inc.\DE |
| 1.53% | 1.59% | #7 | $383.7万 | 54.0万股 | $356.2万 | 53.2万股 | +7,900股+1.48% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #72 | $329.9万 | 46.5万股 | $119.6万 | 17.9万股 | +28.6万股+159.99% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #84 | $197.7万 | 27.8万股 | $277.9万 | 41.5万股 | -13.7万股-32.93% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #106 | $181.3万 | 25.5万股 | $1.9万 | 2,894股 | +25.2万股+8,722.77% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #109 | $124.0万 | 17.5万股 | $110.3万 | 17.9万股 | -3,813股-2.14% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #47 | $123.7万 | 17.4万股 | $68.3万 | 10.2万股 | +7.2万股+70.62% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.05% | — | #29 | $120.7万 | 17.0万股 | $0 | 0股 | +17.0万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #90 | $115.8万 | 16.3万股 | $65.0万 | 9.7万股 | +6.6万股+67.96% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #35 | $106.5万 | 15.0万股 | $59.9万 | 9.0万股 | +6.0万股+67.48% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #88 | $93.8万 | 13.2万股 | $85.3万 | 12.8万股 | +4,579股+3.59% | 加仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| <0.01% | <0.01% | #50 | $92.8万 | 13.1万股 | $60.9万 | 9.1万股 | +4.0万股+43.46% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.04% | — | #31 | $92.4万 | 13.0万股 | $0 | 0股 | +13.0万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #95 | $84.2万 | 11.9万股 | $66.5万 | 9.9万股 | +1.9万股+19.27% | 加仓 |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.2% | 0.19% | #22 | $79.4万 | 11.2万股 | $74.8万 | 11.2万股 | 00.00% | 持仓不变 |
