| Siren, L.L.C. |
| 0.29% | 0.46% | #4 | $1,444.6万 | 849.8万股 | $1,657.1万 | 849.8万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #58 | $1,324.6万 | 779.2万股 | $400.6万 | 205.4万股 | +573.8万股+279.29% | 加仓 |
| 软银集团SOFTBANK GROUP CORP. |
| 0.06% | 0.1% | #15 | $1,035.4万 | 609.0万股 | $1,187.6万 | 609.0万股 | 00.00% | 持仓不变 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.01% | <0.01% | #21 | $882.5万 | 519.1万股 | $258.7万 | 132.7万股 | +386.5万股+291.32% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $793.8万 | 467.0万股 | $758.9万 | 389.2万股 | +77.8万股+19.98% | 加仓 |
| MIC Capital Management UK LLP |
| 1.92% | 2.47% | #1 | $758.3万 | 446.1万股 | $869.8万 | 446.1万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #53 | $594.8万 | 349.9万股 | $682.2万 | 349.9万股 | +211股+0.01% | 加仓 |
| 惠康信托WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST |
| 0.06% | 0.08% | #13 | $562.6万 | 330.9万股 | $645.3万 | 330.9万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $443.3万 | 260.7万股 | $212.0万 | 108.7万股 | +152.0万股+139.89% | 加仓 |
| ICONIQ 资本ICONIQ Capital, LLC |
| 0.13% | 0.11% | #10 | $435.0万 | 255.9万股 | $499.0万 | 255.9万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #30 | $381.6万 | 224.5万股 | $397.2万 | 203.7万股 | +20.8万股+10.22% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.07% | — | #12 | $363.8万 | 214.0万股 | $0 | 0股 | +214.0万股 | 新买入 |
| Lunate Capital Ltd |
| 1.84% | 3.44% | #2 | $361.1万 | 212.4万股 | $414.2万 | 212.4万股 | 00.00% | 持仓不变 |
| Boxer Capital Management, LLC |
| 0.26% | — | #5 | $340.0万 | 200.0万股 | $0 | 0股 | +200.0万股 | 新买入 |
| JOHNSON & JOHNSON |
| 0.39% | 0.55% | #3 | $314.4万 | 184.9万股 | $360.6万 | 184.9万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #71 | $269.0万 | 158.2万股 | $77.8万 | 39.9万股 | +118.3万股+296.80% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.01% | 0.01% | #22 | $234.5万 | 138.0万股 | $203.6万 | 104.4万股 | +33.5万股+32.11% | 加仓 |
| Ikarian Capital, LLC |
| 0.23% | 0.2% | #7 | $217.3万 | 127.8万股 | $249.3万 | 127.8万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #29 | $214.6万 | 126.2万股 | $270.9万 | 138.9万股 | -12.7万股-9.12% | 减仓 |
| Affinity Asset Advisors, LLC |
| 0.08% | — | #11 | $182.0万 | 107.1万股 | $0 | 0股 | +107.1万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #57 | $181.7万 | 106.9万股 | $82.1万 | 42.1万股 | +64.8万股+153.92% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #37 | $153.8万 | 90.4万股 | $233.1万 | 119.5万股 | -29.1万股-24.33% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #78 | $152.1万 | 89.5万股 | $36.0万 | 18.5万股 | +71.0万股+384.10% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #60 | $140.0万 | 82.4万股 | $100.7万 | 51.6万股 | +30.7万股+59.55% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $136.1万 | 80.1万股 | $38.4万 | 19.7万股 | +60.4万股+306.63% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #66 | $135.3万 | 79.6万股 | $297.4万 | 152.5万股 | -73.0万股-47.83% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| <0.01% | — | #34 | $133.4万 | 78.5万股 | $0 | 0股 | +78.5万股 | 新买入 |
| Stonepine Capital Management, LLC |
| 0.19% | 0.47% | #8 | $125.0万 | 50.0万股 | $117.0万 | 60.0万股 | -10.0万股-16.67% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $120.1万 | 70.7万股 | $104.3万 | 53.5万股 | +17.2万股+32.08% | 加仓 |
| 阿尔法核心资本AlphaCore Capital LLC |
| 0.02% | 0.03% | #18 | $108.6万 | 63.9万股 | $124.6万 | 63.9万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #61 | $98.2万 | 57.8万股 | $69.2万 | 35.5万股 | +22.3万股+62.78% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #38 | $91.2万 | 53.6万股 | $73.8万 | 38.1万股 | +15.5万股+40.55% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #50 | $86.6万 | 50.9万股 | $537.2万 | 275.5万股 | -224.6万股-81.52% | 减仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #31 | $68.9万 | 40.5万股 | $53.4万 | 27.4万股 | +13.1万股+48.00% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #42 | $61.7万 | 36.3万股 | $30.5万 | 15.6万股 | +20.7万股+132.47% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #23 | $57.0万 | 33.5万股 | $65.4万 | 33.5万股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #90 | $54.3万 | 31.9万股 | $50.0万 | 27.5万股 | +4.5万股+16.25% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #83 | $51.7万 | 30.4万股 | $110.8万 | 56.8万股 | -26.4万股-46.53% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #85 | $45.9万 | 27.0万股 | $145.8万 | 74.8万股 | -47.8万股-63.91% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #77 | $42.1万 | 24.8万股 | $7.6万 | 3.9万股 | +20.8万股+531.78% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #87 | $41.3万 | 24.3万股 | $40.2万 | 20.6万股 | +3.7万股+18.10% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.03% | 0.03% | #17 | $41.0万 | 24.1万股 | $42.5万 | 21.8万股 | +2.3万股+10.63% | 加仓 |
| Cerity合伙人Cerity Partners LLC |
| <0.01% | <0.01% | #45 | $40.7万 | 24.0万股 | $50.8万 | 26.0万股 | -2.1万股-7.96% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.01% | <0.01% | #25 | $40.4万 | 23.8万股 | $31.3万 | 16.0万股 | +7.7万股+48.30% | 加仓 |
| Velan Capital Investment Management LP |
| 0.24% | 0.1% | #6 | $39.1万 | 23.0万股 | $15.6万 | 8.0万股 | +15.0万股+187.50% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #24 | $38.3万 | 22.5万股 | $43.9万 | 22.5万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.02% | <0.01% | #19 | $35.7万 | 21.0万股 | $6.5万 | 3.3万股 | +17.7万股+534.44% | 加仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #56 | $34.0万 | 20.0万股 | $25.2万 | 12.9万股 | +7.1万股+54.70% | 加仓 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | <0.01% | #59 | $33.7万 | 19.8万股 | $27.3万 | 14.0万股 | +5.8万股+41.51% | 加仓 |
| Addis & Hill, Inc |
| 0.15% | 0.19% | #9 | $27.8万 | 16.3万股 | $31.9万 | 16.3万股 | 00.00% | 持仓不变 |
