| 木星资产管理Jupiter Topco LLC |
| 0.05% | — | #18 | $1.22亿 | 131.2万股 | $0 | 0股 | +131.2万股 | 新买入 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.54% | 0.39% | #5 | $6,177.7万 | 66.7万股 | $3,655.6万 | 66.7万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #54 | $3,229.7万 | 34.9万股 | $1,734.5万 | 31.7万股 | +3.2万股+10.19% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.31% | 0.21% | #10 | $2,997.6万 | 32.4万股 | $1,773.8万 | 32.4万股 | 00.00% | 持仓不变 |
| Saturn V Capital Management LP |
| 4.14% | 3.43% | #1 | $2,888.6万 | 31.2万股 | $1,893.7万 | 34.6万股 | -3.4万股-9.74% | 减仓 |
| Siren, L.L.C. |
| 0.51% | 0.41% | #6 | $2,501.0万 | 27.0万股 | $1,480.0万 | 27.0万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.93% | 0.85% | #2 | $2,014.7万 | 21.8万股 | $1,448.0万 | 26.4万股 | -4.7万股-17.66% | 减仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.05% | 0.04% | #19 | $1,985.8万 | 21.4万股 | $1,241.1万 | 22.7万股 | -1.2万股-5.32% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #56 | $1,941.7万 | 21.0万股 | $1,197.0万 | 21.8万股 | -8,752股-4.01% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.03% | #23 | $1,936.9万 | 20.9万股 | $1,694.1万 | 30.9万股 | -10.0万股-32.34% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.45% | 0.21% | #8 | $1,882.6万 | 20.3万股 | $723.8万 | 13.2万股 | +7.1万股+53.92% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #38 | $1,467.0万 | 15.8万股 | $955.2万 | 17.4万股 | -1.6万股-9.12% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.27% | — | #11 | $1,457.6万 | 15.7万股 | $0 | 0股 | +15.7万股 | 新买入 |
| 康得利安资管Candriam S.C.A. |
| 0.06% | — | #17 | $1,325.9万 | 14.3万股 | $0 | 0股 | +14.3万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #27 | $1,245.7万 | 13.5万股 | $747.6万 | 13.6万股 | -1,900股-1.39% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #53 | $1,042.6万 | 11.3万股 | $547.6万 | 10.0万股 | +1.3万股+12.67% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.02% | 0.02% | #24 | $925.9万 | 10.0万股 | $547.9万 | 10.0万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #63 | $856.9万 | 9.3万股 | $484.1万 | 8.8万股 | +4,196股+4.75% | 加仓 |
| Vivo Capital, LLC |
| 0.77% | 0.41% | #4 | $837.9万 | 9.1万股 | $495.8万 | 9.1万股 | 00.00% | 持仓不变 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.05% | 0.01% | #20 | $778.1万 | 8.4万股 | $181.7万 | 3.3万股 | +5.1万股+153.47% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #42 | $712.4万 | 7.7万股 | $430.7万 | 7.9万股 | -1,676股-2.13% | 减仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.16% | 0.1% | #13 | $701.2万 | 7.6万股 | $358.4万 | 6.5万股 | +1.0万股+15.76% | 加仓 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.11% | — | #15 | $517.0万 | 5.6万股 | $0 | 0股 | +5.6万股 | 新买入 |
| 纽伯格伯曼集团Neuberger Berman Group LLC |
| <0.01% | <0.01% | #37 | $511.0万 | 5.5万股 | $232.5万 | 4.2万股 | +1.3万股+30.07% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $465.8万 | 5.0万股 | $290.1万 | 5.3万股 | -2,640股-4.99% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $452.0万 | 4.9万股 | $252.0万 | 4.6万股 | +2,829股+6.15% | 加仓 |
| Ikarian Capital, LLC |
| 0.47% | — | #7 | $443.1万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #58 | $342.6万 | 3.7万股 | $320.2万 | 5.8万股 | -2.1万股-36.68% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $320.7万 | 3.5万股 | $174.6万 | 3.2万股 | +2,779股+8.72% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #47 | $287.1万 | 3.1万股 | $157.9万 | 2.9万股 | +2,186股+7.58% | 加仓 |
| STEMPOINT CAPITAL LP |
| 0.4% | — | #9 | $278.9万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $261.8万 | 2.8万股 | $155.9万 | 2.8万股 | -167股-0.59% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #61 | $252.4万 | 2.7万股 | $216.1万 | 3.9万股 | -1.2万股-30.88% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #75 | $165.9万 | 1.8万股 | $128.3万 | 1.6万股 | +2,208股+14.05% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #60 | $164.8万 | 1.8万股 | $37.4万 | 6,819股 | +1.1万股+161.04% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #70 | $149.6万 | 1.6万股 | $190.2万 | 3.5万股 | -1.9万股-53.44% | 减仓 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #43 | $137.5万 | 1.5万股 | $78.1万 | 1.4万股 | +601股+4.22% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.02% | — | #26 | $136.0万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #66 | $129.2万 | 1.4万股 | $68.8万 | 1.3万股 | +1,395股+11.11% | 加仓 |
| Ishara Investments LP |
| 0.82% | — | #3 | $113.9万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #48 | $113.4万 | 1.2万股 | $53.5万 | 9,765股 | +2,487股+25.47% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | — | #34 | $111.1万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| Creative Planning财富管理Creative Planning |
| <0.01% | <0.01% | #55 | $71.9万 | 7,768股 | $32.8万 | 5,987股 | +1,781股+29.75% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | — | #21 | $69.7万 | 7,532股 | $0 | 0股 | +7,532股 | 新买入 |
| XTX资本XTX Topco Ltd |
| 0.01% | — | #31 | $60.5万 | 6,536股 | $0 | 0股 | +6,536股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #69 | $55.4万 | 5,980股 | $30.4万 | 5,551股 | +429股+7.73% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #72 | $54.0万 | 5,833股 | $136.6万 | 2.5万股 | -1.9万股-76.61% | 减仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #57 | $52.1万 | 5,630股 | $27.1万 | 4,946股 | +684股+13.83% | 加仓 |
| GERBER, LLC |
| 0.24% | 0.17% | #12 | $51.9万 | 5,601股 | $30.7万 | 5,601股 | 00.00% | 持仓不变 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #68 | $50.7万 | 5,474股 | $0 | 0股 | +5,474股 | 新买入 |
