| Caligan Partners LP |
| 1.46% | 2.03% | #4 | $3,107.2万 | 796.7万股 | $3,051.4万 | 796.7万股 | 00.00% | 持仓不变 |
| Vivo Capital, LLC |
| 2.6% | 3.64% | #1 | $2,847.0万 | 730.0万股 | $4,373.9万 | 1,142.0万股 | -412.0万股-36.08% | 减仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.39% | 0.48% | #7 | $2,584.7万 | 662.8万股 | $2,463.4万 | 643.2万股 | +19.6万股+3.04% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.02% | #20 | $2,498.2万 | 640.6万股 | $1,304.3万 | 340.6万股 | +300.0万股+88.09% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.15% | 0.18% | #12 | $1,716.6万 | 440.2万股 | $1,685.8万 | 440.2万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #23 | $1,466.6万 | 376.0万股 | $1,440.2万 | 376.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #49 | $1,195.7万 | 306.6万股 | $115.4万 | 30.1万股 | +276.5万股+917.51% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $1,159.4万 | 297.3万股 | $955.1万 | 249.4万股 | +47.9万股+19.22% | 加仓 |
| Commodore Capital LP |
| 0.67% | 0.98% | #5 | $1,119.3万 | 287.0万股 | $1,685.8万 | 440.2万股 | -153.2万股-34.79% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #29 | $1,072.1万 | 274.9万股 | $1,161.5万 | 303.3万股 | -28.4万股-9.35% | 减仓 |
| Spruce Street Capital LP |
| 1.68% | 2.02% | #3 | $857.4万 | 219.9万股 | $842.0万 | 219.9万股 | 00.00% | 持仓不变 |
| 塞萨资本Sessa Capital IM, L.P. |
| 0.14% | 0.15% | #13 | $857.4万 | 219.8万股 | $842.0万 | 219.8万股 | 00.00% | 持仓不变 |
| Affinity Asset Advisors, LLC |
| 0.27% | 0.11% | #8 | $594.8万 | 152.5万股 | $220.2万 | 57.5万股 | +95.0万股+165.22% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.08% | 0.07% | #16 | $577.8万 | 148.2万股 | $567.5万 | 148.2万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #45 | $498.2万 | 127.7万股 | $115.7万 | 30.2万股 | +97.5万股+322.86% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.04% | #24 | $460.3万 | 118.0万股 | $1,092.2万 | 285.2万股 | -167.1万股-58.61% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #26 | $457.3万 | 117.3万股 | $526.9万 | 137.6万股 | -20.3万股-14.75% | 减仓 |
| Propel Bio Management, LLC |
| 2.2% | 2.45% | #2 | $419.9万 | 107.7万股 | $388.6万 | 101.3万股 | +6.4万股+6.30% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.12% | 0.16% | #15 | $351.0万 | 90.0万股 | $402.2万 | 105.0万股 | -15.0万股-14.29% | 减仓 |
| Seven Fleet Capital Management LP |
| 0.47% | 0.12% | #6 | $287.1万 | 73.6万股 | $38.3万 | 10.0万股 | +63.6万股+636.08% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #40 | $238.3万 | 61.1万股 | $565.3万 | 147.6万股 | -86.5万股-58.61% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #61 | $207.0万 | 53.1万股 | $28.4万 | 7.4万股 | +45.7万股+615.11% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #52 | $182.1万 | 46.7万股 | $17.6万 | 4.6万股 | +42.1万股+917.24% | 加仓 |
| DV EQUITIES, LLC |
| 0.22% | — | #9 | $156.0万 | 40.0万股 | $0 | 0股 | +40.0万股 | 新买入 |
| AWM Investment Company, Inc. |
| 0.13% | 0.17% | #14 | $146.3万 | 37.5万股 | $153.2万 | 40.0万股 | -2.5万股-6.25% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #44 | $145.9万 | 37.4万股 | $75.7万 | 19.8万股 | +17.6万股+89.24% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #48 | $142.7万 | 36.6万股 | $17.9万 | 4.7万股 | +31.9万股+684.76% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #50 | $141.4万 | 36.2万股 | $22.0万 | 5.7万股 | +30.5万股+531.23% | 加仓 |
| STEMPOINT CAPITAL LP |
| 0.19% | 0.26% | #11 | $133.6万 | 34.3万股 | $143.6万 | 37.5万股 | -3.2万股-8.63% | 减仓 |
| HB财富管理HB Wealth Management, LLC |
| 0.01% | 0.01% | #27 | $119.9万 | 30.8万股 | $117.8万 | 30.8万股 | 00.00% | 持仓不变 |
| Polymer Capital Management (HK) LTD |
| 0.06% | — | #17 | $119.6万 | 30.7万股 | $0 | 0股 | +30.7万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #55 | $114.9万 | 29.5万股 | $31.6万 | 8.2万股 | +21.2万股+257.69% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #65 | $114.2万 | 29.3万股 | $0 | 0股 | +29.3万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #35 | $83.7万 | 21.5万股 | $69.4万 | 18.1万股 | +3.3万股+18.46% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $74.6万 | 19.1万股 | $43.6万 | 11.4万股 | +7.7万股+67.90% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $56.1万 | 14.4万股 | $26.7万 | 7.0万股 | +7.4万股+106.60% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #57 | $42.1万 | 10.8万股 | $0 | 0股 | +10.8万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #63 | $41.2万 | 10.6万股 | $0 | 0股 | +10.6万股 | 新买入 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.01% | 0.01% | #28 | $40.9万 | 10.5万股 | $71.7万 | 18.7万股 | -8.2万股-44.00% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #51 | $33.0万 | 8.5万股 | $14.3万 | 3.7万股 | +4.7万股+126.10% | 加仓 |
| ALPS顾问ALPS ADVISORS INC |
| <0.01% | — | #31 | $30.3万 | 7.8万股 | $0 | 0股 | +7.8万股 | 新买入 |
| Stonepine Capital Management, LLC |
| 0.04% | 0.08% | #19 | $28.6万 | 7.3万股 | $19.2万 | 5.0万股 | +2.3万股+46.54% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #64 | $22.8万 | 5.8万股 | $0 | 0股 | +5.8万股 | 新买入 |
| Pathstone控股Pathstone Holdings, LLC |
| <0.01% | <0.01% | #36 | $19.8万 | 5.1万股 | $19.4万 | 5.1万股 | 00.00% | 持仓不变 |
| Kestra顾问服务Kestra Advisory Services, LLC |
| <0.01% | <0.01% | #34 | $19.4万 | 5.0万股 | $23.6万 | 6.2万股 | -1.2万股-19.32% | 减仓 |
| FIFTH LANE CAPITAL, LP |
| 0.21% | 0.22% | #10 | $17.8万 | 4.7万股 | $17.8万 | 4.7万股 | 00.00% | 持仓不变 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #53 | $17.6万 | 4.5万股 | $0 | 0股 | +4.5万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #72 | $17.2万 | 4.4万股 | $0 | 0股 | +4.4万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #66 | $16.5万 | 4.2万股 | $0 | 0股 | +4.2万股 | 新买入 |
| IFP顾问IFP Advisors, Inc |
| <0.01% | — | #30 | $15.1万 | 3.9万股 | $0 | 0股 | +3.9万股 | 新买入 |
