| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.38% | 0.43% | #10 | $4,349.8万 | 1,775.4万股 | $4,012.5万 | 1,775.4万股 | 00.00% | 持仓不变 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 1.04% | 1.12% | #7 | $4,340.2万 | 1,775.4万股 | $3,902.2万 | 1,775.4万股 | 00.00% | 持仓不变 |
| Versant Venture Management, LLC |
| 18.33% | 19.44% | #1 | $2,980.7万 | 1,216.6万股 | $2,749.5万 | 1,216.6万股 | 00.00% | 持仓不变 |
| 深轨资本Deep Track Capital, LP |
| 0.34% | 0.35% | #11 | $2,318.3万 | 946.3万股 | $2,144.2万 | 948.8万股 | -2.5万股-0.26% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.18% | 0.2% | #13 | $2,130.4万 | 869.6万股 | $1,965.2万 | 869.6万股 | 00.00% | 持仓不变 |
| Venrock Adviser, LLC |
| 0.65% | 0.73% | #9 | $2,130.4万 | 869.6万股 | $1,965.2万 | 869.6万股 | 00.00% | 持仓不变 |
| Commodore Capital LP |
| 1.27% | 1.14% | #5 | $2,130.4万 | 869.6万股 | $1,965.2万 | 869.6万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $1,982.5万 | 809.2万股 | $344.5万 | 152.4万股 | +656.7万股+430.81% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $1,397.4万 | 570.4万股 | $1,285.1万 | 568.6万股 | +1.7万股+0.31% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #22 | $1,353.1万 | 552.3万股 | $1,134.0万 | 501.8万股 | +50.5万股+10.07% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.02% | #24 | $1,220.2万 | 498.1万股 | $1,348.0万 | 596.5万股 | -98.4万股-16.50% | 减仓 |
| Seven Fleet Capital Management LP |
| 1.76% | 2.11% | #3 | $1,065.2万 | 434.8万股 | $666.2万 | 294.8万股 | +140.0万股+47.49% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.03% | #20 | $1,043.1万 | 425.8万股 | $687.8万 | 304.3万股 | +121.4万股+39.89% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #32 | $1,027.8万 | 419.5万股 | $1,054.8万 | 466.7万股 | -47.2万股-10.12% | 减仓 |
| Trails Edge Capital Partners, LP |
| 1.61% | 1.27% | #4 | $1,013.1万 | 413.5万股 | $553.7万 | 245.0万股 | +168.5万股+68.77% | 加仓 |
| Spruce Street Capital LP |
| 1.95% | 2.21% | #2 | $994.5万 | 405.9万股 | $917.3万 | 405.9万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #25 | $928.4万 | 379.0万股 | $856.4万 | 379.0万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #45 | $730.2万 | 298.0万股 | $294.3万 | 130.2万股 | +167.8万股+128.90% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #29 | $661.3万 | 269.9万股 | $535.9万 | 237.1万股 | +32.8万股+13.81% | 加仓 |
| DAFNA Capital Management LLC |
| 1.12% | 1.25% | #6 | $588.1万 | 240.0万股 | $550.2万 | 243.4万股 | -3.4万股-1.39% | 减仓 |
| STEMPOINT CAPITAL LP |
| 0.75% | — | #8 | $525.8万 | 214.6万股 | $0 | 0股 | +214.6万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #57 | $451.6万 | 184.3万股 | $87.4万 | 38.7万股 | +145.6万股+376.61% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #43 | $390.5万 | 159.4万股 | $52.2万 | 23.1万股 | +136.3万股+590.56% | 加仓 |
| DV Trading LLC |
| 0.11% | — | #16 | $343.0万 | 140.0万股 | $0 | 0股 | +140.0万股 | 新买入 |
| Rock Springs Capital Management LP |
| 0.16% | 0.17% | #14 | $319.6万 | 130.4万股 | $294.8万 | 130.4万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #31 | $308.1万 | 125.8万股 | $204.9万 | 90.7万股 | +35.1万股+38.69% | 加仓 |
| Casdin Capital, LLC |
| 0.15% | 0.21% | #15 | $300.9万 | 122.8万股 | $277.6万 | 122.8万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #61 | $248.8万 | 101.5万股 | $0 | 0股 | +101.5万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #44 | $180.7万 | 73.8万股 | $156.6万 | 69.3万股 | +4.5万股+6.43% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #34 | $131.8万 | 53.8万股 | $152.2万 | 67.4万股 | -13.6万股-20.13% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #66 | $93.4万 | 38.1万股 | $14.0万 | 6.2万股 | +31.9万股+514.11% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #58 | $92.8万 | 37.9万股 | $17.9万 | 7.9万股 | +29.9万股+377.07% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #63 | $86.2万 | 35.2万股 | $3.0万 | 1.3万股 | +33.9万股+2,585.27% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #60 | $73.3万 | 29.9万股 | $2.9万 | 1.3万股 | +28.6万股+2,218.48% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #59 | $66.5万 | 27.1万股 | $12.2万 | 5.5万股 | +21.6万股+391.98% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #67 | $56.9万 | 23.2万股 | $3.2万 | 1.4万股 | +21.8万股+1,534.96% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #52 | $42.6万 | 17.4万股 | $13.3万 | 5.9万股 | +11.5万股+196.32% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #64 | $40.1万 | 16.4万股 | $0 | 0股 | +16.4万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #82 | $38.9万 | 15.9万股 | $32.8万 | 14.5万股 | +1.4万股+9.51% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #80 | $36.9万 | 15.0万股 | $47.6万 | 21.0万股 | -6.0万股-28.53% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #72 | $36.5万 | 14.9万股 | $90 | 40股 | +14.9万股+372,187.50% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #51 | $31.5万 | 12.8万股 | $0 | 0股 | +12.8万股 | 新买入 |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | 0.01% | #21 | $29.5万 | 12.1万股 | $17.4万 | 7.7万股 | +4.4万股+56.96% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #65 | $29.5万 | 12.0万股 | $0 | 0股 | +12.0万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #86 | $28.4万 | 11.6万股 | $51.2万 | 22.7万股 | -11.1万股-48.92% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #83 | $24.8万 | 10.1万股 | $0 | 0股 | +10.1万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #87 | $24.1万 | 9.8万股 | $6.4万 | 2.8万股 | +7.0万股+246.13% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #71 | $22.4万 | 9.1万股 | $20.6万 | 9.1万股 | 00.00% | 持仓不变 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #50 | $22.1万 | 9.0万股 | $27.0万 | 12.0万股 | -2.9万股-24.56% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #79 | $20.1万 | 8.2万股 | $0 | 0股 | +8.2万股 | 新买入 |
