| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.28% | 0.82% | #7 | $1.47亿 | 1,130.1万股 | $7,741.1万 | 1,130.1万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #37 | $8,854.6万 | 679.0万股 | $4.4万 | 6,397股 | +678.4万股+106,049.19% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | <0.01% | #34 | $4,439.9万 | 340.5万股 | $58.9万 | 8.6万股 | +331.9万股+3,861.68% | 加仓 |
| BRAIDWELL LP |
| 1.35% | 0.35% | #6 | $3,647.8万 | 279.7万股 | $1,047.8万 | 153.0万股 | +126.8万股+82.87% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | — | #25 | $3,267.8万 | 250.6万股 | $0 | 0股 | +250.6万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #63 | $3,070.8万 | 235.5万股 | $275.1万 | 40.2万股 | +195.3万股+486.30% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #45 | $2,774.0万 | 212.7万股 | $1,313.2万 | 191.7万股 | +21.0万股+10.97% | 加仓 |
| Cormorant Asset Management, LP |
| 1.39% | — | #4 | $2,746.2万 | 210.6万股 | $0 | 0股 | +210.6万股 | 新买入 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.24% | — | #18 | $2,528.5万 | 193.9万股 | $0 | 0股 | +193.9万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $2,215.0万 | 169.9万股 | $807.4万 | 117.9万股 | +52.0万股+44.12% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.06% | — | #22 | $2,063.3万 | 158.2万股 | $0 | 0股 | +158.2万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #47 | $1,692.6万 | 129.8万股 | $236.8万 | 34.6万股 | +95.2万股+275.50% | 加仓 |
| Redmile Group, LLC |
| 1.07% | — | #8 | $1,599.1万 | 122.6万股 | $0 | 0股 | +122.6万股 | 新买入 |
| GREAT POINT PARTNERS LLC |
| 2.46% | 2.1% | #3 | $1,304.0万 | 100.0万股 | $913.9万 | 133.4万股 | -33.4万股-25.04% | 减仓 |
| Affinity Asset Advisors, LLC |
| 0.57% | 0.25% | #12 | $1,267.5万 | 97.2万股 | $479.5万 | 70.0万股 | +27.2万股+38.86% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $1,184.3万 | 90.8万股 | $874.2万 | 127.6万股 | -36.8万股-28.84% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.49% | 0.24% | #13 | $1,072.7万 | 82.3万股 | $409.4万 | 59.8万股 | +22.5万股+37.64% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.06% | 0.03% | #23 | $1,030.2万 | 79.0万股 | $411.6万 | 60.1万股 | +18.9万股+31.46% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #60 | $1,020.2万 | 78.2万股 | $214.5万 | 31.3万股 | +46.9万股+149.90% | 加仓 |
| STEMPOINT CAPITAL LP |
| 1.38% | — | #5 | $968.5万 | 74.3万股 | $0 | 0股 | +74.3万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #70 | $895.6万 | 68.7万股 | $90.4万 | 13.2万股 | +55.5万股+420.28% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #48 | $858.0万 | 65.8万股 | $0 | 0股 | +65.8万股 | 新买入 |
| Parkman Healthcare Partners LLC |
| 0.75% | — | #10 | $734.8万 | 56.3万股 | $0 | 0股 | +56.3万股 | 新买入 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 4.29% | 0.97% | #1 | $679.5万 | 52.1万股 | $136.5万 | 19.9万股 | +32.2万股+161.58% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.82% | 0.46% | #9 | $630.8万 | 48.4万股 | $287.2万 | 41.9万股 | +6.5万股+15.38% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | — | #66 | $487.0万 | 37.3万股 | $0 | 0股 | +37.3万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #72 | $476.1万 | 36.5万股 | $17.4万 | 8.6万股 | +27.9万股+322.88% | 加仓 |
| NAN FUNG TRINITY (HK) Ltd |
| 0.46% | 0.32% | #14 | $470.3万 | 36.1万股 | $288.1万 | 42.1万股 | -6.0万股-14.24% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #61 | $430.7万 | 33.0万股 | $87.6万 | 12.8万股 | +20.2万股+158.23% | 加仓 |
| Ikarian Capital, LLC |
| 0.42% | — | #15 | $391.2万 | 30.0万股 | $0 | 0股 | +30.0万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #43 | $348.3万 | 26.7万股 | $171.3万 | 25.0万股 | +1.7万股+6.80% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #42 | $347.7万 | 26.7万股 | $71.4万 | 10.4万股 | +16.2万股+155.86% | 加仓 |
| Ally Bridge Group (NY) LLC |
| 2.87% | — | #2 | $324.9万 | 24.9万股 | $0 | 0股 | +24.9万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #81 | $312.5万 | 24.0万股 | $0 | 0股 | +24.0万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #57 | $312.3万 | 23.9万股 | $71.5万 | 10.4万股 | +13.5万股+129.28% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #59 | $254.3万 | 19.5万股 | $108.7万 | 15.9万股 | +3.6万股+22.93% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #41 | $251.3万 | 19.3万股 | $148.9万 | 21.7万股 | -2.5万股-11.32% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.01% | #27 | $238.2万 | 18.3万股 | $63.2万 | 9.2万股 | +9.0万股+97.89% | 加仓 |
| 五三银行FIFTH THIRD BANCORP |
| <0.01% | — | #40 | $215.1万 | 16.5万股 | $0 | 0股 | +16.5万股 | 新买入 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #49 | $214.8万 | 16.5万股 | $107.1万 | 15.6万股 | +8,395股+5.37% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #51 | $193.3万 | 14.8万股 | $212.8万 | 31.1万股 | -16.2万股-52.27% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #80 | $171.8万 | 13.2万股 | $127.4万 | 18.6万股 | -5.4万股-29.15% | 减仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.03% | 0.02% | #28 | $169.9万 | 13.0万股 | $92.0万 | 13.4万股 | -4,000股-2.98% | 减仓 |
| ArchPoint Investors |
| 0.36% | 0.2% | #16 | $168.1万 | 12.9万股 | $83.2万 | 12.1万股 | +7,500股+6.18% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.01% | — | #32 | $164.5万 | 12.6万股 | $0 | 0股 | +12.6万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #71 | $161.3万 | 12.4万股 | $0 | 0股 | +12.4万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #77 | $136.4万 | 10.5万股 | $15.1万 | 2.2万股 | +8.3万股+374.51% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #75 | $126.2万 | 9.7万股 | $0 | 0股 | +9.7万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #69 | $112.1万 | 8.6万股 | $0 | 0股 | +8.6万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #84 | $108.5万 | 8.3万股 | $102.7万 | 15.0万股 | -6.7万股-44.50% | 减仓 |
