| 富达投资FMR LLC |
| <0.01% | <0.01% | #30 | $7,440.3万 | 413.4万股 | $7,593.3万 | 413.4万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 1.27% | 1.61% | #9 | $4,947.8万 | 274.9万股 | $5,049.5万 | 274.9万股 | 00.00% | 持仓不变 |
| Fairmount Funds Management LLC |
| 3.27% | 3.65% | #2 | $4,946.2万 | 274.8万股 | $5,047.8万 | 274.8万股 | 00.00% | 持仓不变 |
| Venrock Adviser, LLC |
| 1.16% | 1.46% | #10 | $3,840.4万 | 213.4万股 | $3,919.4万 | 213.4万股 | 00.00% | 持仓不变 |
| Logos Global Management LP |
| 1.47% | 0.44% | #6 | $3,420.0万 | 190.0万股 | $886.4万 | 48.3万股 | +141.8万股+293.78% | 加仓 |
| FCPM III SERVICES B.V. |
| 4.02% | 4.27% | #1 | $3,020.1万 | 167.8万股 | $3,082.2万 | 167.8万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.04% | #22 | $2,993.3万 | 166.3万股 | $2,773.9万 | 151.0万股 | +15.3万股+10.12% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.69% | 0.77% | #12 | $2,934.0万 | 163.0万股 | $2,755.5万 | 150.0万股 | +13.0万股+8.67% | 加仓 |
| Opaleye Management Inc. |
| 2.15% | 3.18% | #4 | $2,374.8万 | 131.9万股 | $2,411.3万 | 131.3万股 | +6,736股+0.51% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #45 | $2,289.2万 | 127.2万股 | $212.6万 | 11.6万股 | +115.6万股+998.95% | 加仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 0.95% | 1.08% | #11 | $2,088.0万 | 116.0万股 | $2,130.9万 | 116.0万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $1,382.0万 | 76.8万股 | $1,472.2万 | 80.1万股 | -3.4万股-4.20% | 减仓 |
| Boxer Capital Management, LLC |
| 0.62% | 1.09% | #13 | $816.6万 | 45.4万股 | $833.4万 | 45.4万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $726.9万 | 40.4万股 | $594.4万 | 32.4万股 | +8.0万股+24.82% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #43 | $692.4万 | 38.5万股 | $191.6万 | 10.4万股 | +28.0万股+269.00% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| <0.01% | <0.01% | #28 | $681.3万 | 37.9万股 | $281.0万 | 15.3万股 | +22.6万股+147.43% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.06% | 0.07% | #19 | $671.1万 | 37.3万股 | $684.9万 | 37.3万股 | 00.00% | 持仓不变 |
| NEXTBio Capital Management LP |
| 3.09% | 3.18% | #3 | $671.1万 | 37.3万股 | $684.9万 | 37.3万股 | 00.00% | 持仓不变 |
| Remedium Capital Partners, LLC |
| 1.44% | 2.36% | #7 | $650.3万 | 36.1万股 | $663.6万 | 36.1万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #54 | $568.1万 | 31.6万股 | $71.8万 | 3.9万股 | +27.7万股+707.81% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #36 | $544.6万 | 30.3万股 | $0 | 0股 | +30.3万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #26 | $540.0万 | 30.0万股 | $551.1万 | 30.0万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #40 | $496.0万 | 27.6万股 | $557.7万 | 30.4万股 | -2.8万股-9.21% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #31 | $385.7万 | 21.4万股 | $368.8万 | 20.1万股 | +1.4万股+6.73% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.06% | 0.07% | #20 | $372.5万 | 20.7万股 | $380.2万 | 20.7万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #55 | $339.8万 | 18.9万股 | $0 | 0股 | +18.9万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #35 | $336.4万 | 18.7万股 | $212.8万 | 11.6万股 | +7.1万股+61.34% | 加仓 |
| STEMPOINT CAPITAL LP |
| 0.47% | — | #14 | $328.3万 | 18.2万股 | $0 | 0股 | +18.2万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #42 | $315.3万 | 17.5万股 | $151.9万 | 8.3万股 | +9.2万股+111.81% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #48 | $249.8万 | 13.9万股 | $31.6万 | 1.7万股 | +12.2万股+705.49% | 加仓 |
| Exome Asset Management LLC |
| 1.42% | 1.46% | #8 | $230.0万 | 12.8万股 | $281.4万 | 15.3万股 | -2.5万股-16.59% | 减仓 |
| SECTORAL ASSET MANAGEMENT INC |
| 1.52% | — | #5 | $218.3万 | 12.1万股 | $0 | 0股 | +12.1万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #27 | $170.1万 | 9.4万股 | $135.9万 | 7.4万股 | +2.0万股+27.69% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #46 | $135.4万 | 7.5万股 | $90.8万 | 4.9万股 | +2.6万股+52.21% | 加仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.05% | 0.07% | #21 | $133.2万 | 7.4万股 | $135.9万 | 7.4万股 | 00.00% | 持仓不变 |
| 黑石集团Blackstone Inc. |
| <0.01% | — | #29 | $112.8万 | 6.3万股 | $0 | 0股 | +6.3万股 | 新买入 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.11% | 0.24% | #15 | $106.4万 | 5.9万股 | $239.7万 | 13.1万股 | -7.1万股-54.71% | 减仓 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| 0.02% | — | #23 | $91.5万 | 5.1万股 | $0 | 0股 | +5.1万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #58 | $90.5万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #51 | $85.7万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #57 | $82.4万 | 4.6万股 | $0 | 0股 | +4.6万股 | 新买入 |
| Stonepine Capital Management, LLC |
| 0.11% | 0.63% | #16 | $72.0万 | 4.0万股 | $156.1万 | 8.5万股 | -4.5万股-52.94% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #66 | $46.5万 | 2.6万股 | $53.8万 | 2.9万股 | -3,456股-11.80% | 减仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #44 | $45.9万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.01% | 0.01% | #25 | $45.0万 | 2.5万股 | $45.9万 | 2.5万股 | 00.00% | 持仓不变 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #41 | $43.5万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | — | #52 | $41.0万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #62 | $35.5万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | <0.01% | #32 | $34.6万 | 1.9万股 | $38.4万 | 2.1万股 | -1,690股-8.08% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.05% | #24 | $32.9万 | 1.8万股 | $92.4万 | 5.0万股 | -3.2万股-63.65% | 减仓 |
