| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.31% | 0.38% | #4 | $3,611.6万 | 2,006.5万股 | $3,551.4万 | 2,006.5万股 | 00.00% | 持仓不变 |
| Commodore Capital LP |
| 0.48% | 0.46% | #1 | $805.5万 | 447.5万股 | $792.1万 | 447.5万股 | 00.00% | 持仓不变 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.02% | 0.02% | #18 | $626.8万 | 348.2万股 | $616.4万 | 348.2万股 | 00.00% | 持仓不变 |
| Laurion 资本管理Laurion Capital Management LP |
| 0.13% | 0.21% | #8 | $495.2万 | 275.1万股 | $486.9万 | 275.1万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.21% | 0.17% | #6 | $466.4万 | 259.1万股 | $284.6万 | 160.8万股 | +98.3万股+61.17% | 加仓 |
| Vivo Capital, LLC |
| 0.38% | 0.34% | #3 | $418.5万 | 232.5万股 | $411.5万 | 232.5万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #45 | $348.5万 | 193.6万股 | $343.0万 | 193.8万股 | -1,779股-0.09% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #30 | $321.6万 | 178.7万股 | $368.0万 | 207.9万股 | -29.2万股-14.06% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #24 | $273.6万 | 152.0万股 | $10.1万 | 5.7万股 | +146.3万股+2,576.49% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #47 | $234.8万 | 130.4万股 | $226.2万 | 127.8万股 | +2.6万股+2.07% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #28 | $156.1万 | 86.7万股 | $52.8万 | 29.9万股 | +56.8万股+190.38% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.1% | <0.01% | #11 | $153.5万 | 85.3万股 | $6.8万 | 3.8万股 | +81.5万股+2,127.58% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #39 | $120.9万 | 67.1万股 | $64.4万 | 36.4万股 | +30.8万股+84.61% | 加仓 |
| AWM Investment Company, Inc. |
| 0.09% | 0.36% | #12 | $108.0万 | 60.0万股 | $324.1万 | 183.1万股 | -123.1万股-67.23% | 减仓 |
| MONIMUS CAPITAL MANAGEMENT, LP |
| 0.24% | 0.29% | #5 | $105.8万 | 58.8万股 | $106.0万 | 59.9万股 | -1.1万股-1.83% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #31 | $95.2万 | 52.9万股 | $25.9万 | 14.7万股 | +38.2万股+260.91% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #46 | $94.3万 | 52.3万股 | $94.9万 | 53.6万股 | -1.3万股-2.34% | 减仓 |
| Creek Drive Management Group LLC |
| 0.39% | 0.18% | #2 | $81.0万 | 45.0万股 | $79.7万 | 45.0万股 | 00.00% | 持仓不变 |
| Ikarian Capital, LLC |
| 0.09% | 0.11% | #13 | $80.5万 | 44.7万股 | $132.2万 | 74.7万股 | -30.0万股-40.15% | 减仓 |
| DIADEMA PARTNERS LP |
| 0.08% | 0.05% | #14 | $67.2万 | 37.3万股 | $26.7万 | 15.1万股 | +22.2万股+147.33% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #20 | $65.9万 | 36.6万股 | $75.7万 | 42.8万股 | -6.2万股-14.39% | 减仓 |
| Rosalind Advisors, Inc. |
| 0.15% | — | #7 | $63.0万 | 35.0万股 | $0 | 0股 | +35.0万股 | 新买入 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $50.4万 | 28.0万股 | $49.5万 | 28.0万股 | 00.00% | 持仓不变 |
| Boxer Capital Management, LLC |
| 0.04% | 0.06% | #17 | $49.1万 | 27.3万股 | $48.3万 | 27.3万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #42 | $47.1万 | 26.1万股 | $46.0万 | 26.0万股 | +1,779股+0.69% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | <0.01% | #23 | $44.2万 | 24.5万股 | $23.2万 | 13.1万股 | +11.4万股+87.07% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #60 | $41.3万 | 22.9万股 | $40.6万 | 22.9万股 | 00.00% | 持仓不变 |
| Artia Global Partners LP |
| 0.07% | 0.07% | #15 | $37.0万 | 20.5万股 | $36.3万 | 20.5万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #51 | $31.0万 | 17.2万股 | $45.8万 | 25.9万股 | -8.6万股-33.35% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $30.3万 | 16.8万股 | $24.5万 | 13.9万股 | +2.9万股+21.25% | 加仓 |
| READYSTATE 资产管理READYSTATE ASSET MANAGEMENT LP |
| 0.01% | 0.01% | #19 | $20.4万 | 11.5万股 | $20.4万 | 11.5万股 | 00.00% | 持仓不变 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #33 | $20.2万 | 11.2万股 | $12.2万 | 6.9万股 | +4.3万股+62.13% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #52 | $19.9万 | 11.1万股 | $16.6万 | 9.4万股 | +1.7万股+17.70% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #55 | $17.8万 | 9.9万股 | $18.6万 | 10.5万股 | -6,161股-5.87% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #38 | $17.7万 | 9.9万股 | $125.0万 | 70.6万股 | -60.8万股-86.05% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #59 | $17.3万 | 9.6万股 | $157.1万 | 88.7万股 | -79.1万股-89.16% | 减仓 |
| RBF Capital, LLC |
| 0.01% | 0.01% | #21 | $17.1万 | 9.5万股 | $16.8万 | 9.5万股 | 00.00% | 持仓不变 |
| Persistent Asset Partners Ltd |
| 0.05% | 0.03% | #16 | $17.1万 | 9.5万股 | $6.8万 | 3.8万股 | +5.7万股+149.01% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #26 | $16.9万 | 9.4万股 | $7.7万 | 4.4万股 | +5.0万股+114.42% | 加仓 |
| Rangeley Capital, LLC |
| 0.12% | 0.12% | #9 | $12.6万 | 7.0万股 | $12.1万 | 6.8万股 | +1,904股+2.80% | 加仓 |
| Verdad Advisers, LP |
| 0.12% | 0.11% | #10 | $12.0万 | 6.7万股 | $9.6万 | 5.4万股 | +1.3万股+22.99% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #43 | $11.9万 | 6.6万股 | $32.2万 | 18.2万股 | -11.5万股-63.53% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #56 | $9.7万 | 5.4万股 | $39.4万 | 21.7万股 | -16.3万股-75.04% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #62 | $8.8万 | 4.9万股 | $265.7万 | 57.5万股 | -52.6万股-91.51% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #48 | $7.7万 | 4.3万股 | $7.5万 | 4.3万股 | 00.00% | 持仓不变 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | <0.01% | #32 | $7.4万 | 4.1万股 | $28.1万 | 15.9万股 | -11.8万股-74.23% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #44 | $7.1万 | 4.0万股 | $11.7万 | 6.6万股 | -2.6万股-39.79% | 减仓 |
| Rathbones集团Rathbones Group PLC |
| <0.01% | <0.01% | #36 | $5.8万 | 3.2万股 | $5.7万 | 3.2万股 | 00.00% | 持仓不变 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #54 | $3.9万 | 2.2万股 | $354 | 200股 | +2.1万股+10,650.00% | 加仓 |
| Bronte Capital Management Pty Ltd. |
| <0.01% | — | #25 | $3.2万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
